This book constitutes the refereed post-proceedings of the 10th European Performance Engineering Workshop, EPEW 2013, held in Venice, Italy, in September 2013.The 16 regular papers presented together with 8 short papers and 2 invited talks were carefully reviewed and selected from 33 submissions. The Workshop aims to gather academic and industrial researchers working on all aspects of performance engineering.Original papers related to theoretical and methodological issues as well as case studies and automated tool support are solicited in the following areas: performance modeling and evaluation, system and network performance engineering, and software performance engineering.