Proceedings of the Research Symposium on Complexes of Biologically Active Substances with Nucleic Acids and Their Modes of Action

Held at the Walter Reed Army Institute of Research Washington, 16–19 March 1970

AvRobert E. Rhoads

Häftad, Engelska, 2012

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Produktinformation

Utgivningsdatum:2012-01-06
Mått:170 x 244 x 23 mm
Vikt:708 g
Format:Häftad
Språk:Engelska
Serie:Progress in Molecular and Subcellular Biology
Antal sidor:400
Förlag:Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
ISBN:9783642651434

Utforska kategorier

Cellbiologi inom Naturvetenskap och teknik
Farmakologi inom Medicin

Innehållsförteckning

Complexes of Biologically Active Substances with Nucleic Acids — Yesterday, Today, Tomorrow.- Antibiotics and Nucleic Acids.- Kinetics of Binding of Drugs to DNA.- The Binding of Actinomycin D to DNA.- Interaction of Antitumor Antibiotics with DNA: Studies on Sibiromycin.- Anthramyein.- Inhibition of RNA Synthesis by Quinone Antibiotics.- Changes in the Properties of Ribosomes and Transfer RNA Induced by Inhibitors of Protein Synthesis.- Antimalarials and Nucleic Acids.- Chloroquine Binding to Nucleic Acids: Characteristics, Biological Consequences, and a Proposed Binding Model for the interaction.- A Preliminary Nuclear Magnetic Resonance Study of the Effect of pH on the Structure of Chloroquine Diphosphate.- Effects of Chlotoquine and Some Related Compounds on Aminoacylation of Transfer Ribonucleic Acids.- Interaction of Antimalarial Aminoquinolines (Primaquine, Pentaquine, and Chloroquine) with Nucleic Acids, and Effects onVarious Enzymatic Reactions in Vitro.- Interpretation of Antimalarial Activity in Terms of Regression Analyses, Molecular Orbital Calculations, and Theory of DNA-Drug Binding.- Alkaloids, Natural Poly amines and DNA.- Interactions of Alkaloids with DNA.- Physical Studies on the Interaction of Lysergic Acid Diethylamide and Trypanocidal Dyes with DNA and DNA-Containing Genetic Material.- Comments on the Interaction of LSD with DNA.- The Interaction of Polyamines with Nucleic Acids.- Intercalation into Supercoiled DNA.- The Use of Intercalative Dyes in the Study of Closed Circular DNA.- Binding of Drugs to Supercoiled Circular DNA: Evidence for and against Intercalation.- Synthetic Drugs and Dyes Binding to Nucleic Acids.- Mode of Action of Miracil D.- Molecular Biological Effects of Nitroakridin 3582 and Related Compounds.- Binding ofNaphthylvinylpyridines to DNA.- Formation of Yeast Mitochondria: V. Ethidium Bromide as a Probe for the Functions of Mitochondrial DNA.- Studies on tRNA Structure Using Covalently and Noncovalently Bound Fluorescent Dyes.- Antimutagens.- Antimutagens and Antimicrobial Drug Resistance.- Some Studies on the Antimutagenic Action of Polyamines.- Carcinogens and Nucleic Acids.- Interaction and Linkage of Polycyclic Hydrocarbons to Nucleic Acids.- Interaction of N-2-Acetylaminofluorene with RNA.- The Natural State of DNA.- Intercalability, the ? Transition, and the State of DNA in Nature.