Adhesion Molecules: Function and Inhibition

Inbunden, Engelska, 2007

Del i serien Progress in Inflammation Research

2 201 kr

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Beskrivning

Inflammatory cell recruitment requires the concerted action of at least five major sets of adhesion molecules: integrins, immunoglobulin-like molecules, selectins, carbohydrate structures serving as selectin ligands, and certain ectoenzymes. This volume gives a comprehensive overview on the most relevant leukocyte and endothelial adhesion molecules. The chapters are written by leaders in the field and focus on the biology, structure, function, and regulation of adhesion molecules. Currently approved adhesion molecule-based therapies are reviewed and an outlook for future approaches is also provided.The book is of interest to clinicians and scientists from immunology, physiology, cancer research, rheumatology, allergology, infectious diseases, gastroenterology, pulmonology and cardiology.

Produktinformation

Utgivningsdatum:2007-08-16
Mått:165 x 235 x 23 mm
Vikt:748 g
Format:Inbunden
Språk:Engelska
Serie:Progress in Inflammation Research
Antal sidor:309
Förlag:Birkhauser Verlag AG
ISBN:9783764379742

Utforska kategorier

Klinisk medicin och internmedicin inom Medicin

Recensioner i media

From the reviews: "This book is a great and informative text to all those who wish to access and demystify the field of adhesion molecules. The monograph ... deals specifically with adhesion molecules in the whole process of leukocyte extravasation with a focus on inflammation. ... this is a well-organised and highly informative text. ... it provides food for thought relevant to the application of current knowledge. ... this is an eminently accessible and readable volume." (Andrew Devitt, Inflammation Research, Vol. 59, 2010)

Innehållsförteckning

Capture and rolling.- P-selectin glycoprotein ligand-1 (PSGL-1).- L-selectin-mediated leukocyte adhesion and migration.- P- and E-selectin.- Firm adhesion.- Endothelial ICAM-1 functions in adhesion and signaling during leukocyte recruitment.- ?4-integrins: structure, function and secrets.- VCAM-1 and its functions in development and inflammatory diseases.- Lymphocyte function-associated antigen-1 (LFA-1) and macrophage antigen-1 (Mac-1): Cooperative partners in leukocyte emigration and function.- Transendothelial migration.- PECAM: Regulating the start of diapedesis.- Role of ?6?1 integrin in leukocyte adhesion and transmigration.- Vascular adhesion protein-1 (VAP-1).- The role of endothelial cell-selective adhesion molecule (ESAM) in neutrophil emigration into inflamed tissues.- Structure and function of JAM proteins.- Promises and limitations of targeting adhesion molecules for therapy.