This manuscript mainly introduces the historical overview, structure, principle, function, indications and contraindications, types, preparation, monitoring and management of ECMO (extracorporeal membrane oxygenation), prevention and treatment of related complications, weaning and nursing , as well as the transfer of patients, the psychological care of patients and their families, and the construction and management of the ECMO team. This book can be used by medical professionals in major hospitals such as intensive care, cardiovascular, emergency, and respiratory departments. It can also be used as an ECMO training textbook.