Liam Heaney MD MRCP Senior Lecturer, Respiratory Medicine Research Group, Centre for Infection and Immunity, The Queen's University of Belfast, Northern IrelandAndrew Menzies PhD FRCPConsultant, Royal Brompton and Harefield NHS Foundation Trust, London, UK

• Definition, Epidemiology, and Phenotypes of Severe AsthmaThe Economic Burden of Difficult AsthmaClinical Assessment of Difficult AsthmaAdherence in Difficult AsthmaPsychological Morbidity in Difficult to Treat AsthmaDifficult Asthma in ChildrenDifficult Asthma – The Patient’s PerspectiveCo-morbidity in Refractory AsthmaMolecular and Immunological Basis for Severe Therapy-resistant AsthmaMonitoring and Natural History of Refractory AsthmaNovel Treatment Strategies in Refractory Asthma

Liam Heaney MD MRCP Senior Lecturer, Respiratory Medicine Research Group, Centre for Infection and Immunity, The Queen's University of Belfast, Northern IrelandAndrew Menzies PhD FRCPConsultant, Royal Brompton and Harefield NHS Foundation Trust, London, UK

• Definition, Epidemiology, and Phenotypes of Severe AsthmaThe Economic Burden of Difficult AsthmaClinical Assessment of Difficult AsthmaAdherence in Difficult AsthmaPsychological Morbidity in Difficult to Treat AsthmaDifficult Asthma in ChildrenDifficult Asthma – The Patient’s PerspectiveCo-morbidity in Refractory AsthmaMolecular and Immunological Basis for Severe Therapy-resistant AsthmaMonitoring and Natural History of Refractory AsthmaNovel Treatment Strategies in Refractory Asthma

Liam Heaney MD MRCP Senior Lecturer, Respiratory Medicine Research Group, Centre for Infection and Immunity, The Queen's University of Belfast, Northern IrelandAndrew Menzies PhD FRCPConsultant, Royal Brompton and Harefield NHS Foundation Trust, London, UK

• Definition, Epidemiology, and Phenotypes of Severe AsthmaThe Economic Burden of Difficult AsthmaClinical Assessment of Difficult AsthmaAdherence in Difficult AsthmaPsychological Morbidity in Difficult to Treat AsthmaDifficult Asthma in ChildrenDifficult Asthma – The Patient’s PerspectiveCo-morbidity in Refractory AsthmaMolecular and Immunological Basis for Severe Therapy-resistant AsthmaMonitoring and Natural History of Refractory AsthmaNovel Treatment Strategies in Refractory Asthma