Essential Guide to N-of-1 Trials in Health

Inbunden, Engelska, 2015

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Beskrivning

N-of-1 trials, a type of individualized randomized controlled trial, are relevant to almost every discipline in medicine and psychology. They can tell the clinician with precision whether a treatment works in that individual, which distinguishes from the information available from most other trial designs. They have the potential to revolutionize the way clinical medicine is practiced. Whether you are a busy clinician, a researcher or a student, this book provides everything you need to know about N-of-1 trials. Written and edited by some of the world’s leading experts on N-of-1 trials, the book presents state of the art knowledge about N-of-1 trials, with chapters on ethics, statistics, health economics, design, analysis and reporting, and more. Full of examples and well illustrated, it is a comprehensive compendium of issues surrounding the design, conduct, interpretation and implementation of N-of-1 trials in a health system.

Produktinformation

Utgivningsdatum:2015-10-14
Mått:155 x 235 x 19 mm
Vikt:606 g
Format:Inbunden
Språk:Engelska
Antal sidor:245
Upplaga:15001
Förlag:Springer
ISBN:9789401771993

Utforska kategorier

Farmakologi inom Medicin
Medicinsk utrustning och medicinska tekniker inom Medicin

Recensioner i media

"This is a philosophical rethinking of the limitations of randomized controlled trials and the value of cross-over experiments conducted with a single patient. ... This is a book for experienced clinicians who are knowledgeable about current evidence-based treatment modalities and who can objectively recognize when to consider different options for treatment." (Vincent F. Carr, Doody's Book Reviews, January 2016)

Innehållsförteckning

Preface.- Introduction.- What are N-of-1 trials?- N-of-1 trials in the behavioural sciences.- N-of-1 trials in medical contexts.- Aggregated N-of-1 trials.- Methodological considerations for N-of-1 trials.- Randomization, allocation concealment and blinding.- Data collection and quality control.- Individual reporting of N-of-1 trials to patients and clinicians.- Assessing and reporting adverse events.- Research ethics and N-of-1 trials.- Statistical analysis of N-of-1 trials.- The economics of N-of-1 trials.- Reporting N-of-1 trials to professional audiences.- Single patient open trials.- Systematic review and meta-analysis using N-of-1 trials.- Where are N-of-1 trials headed?- Index.