This book constitutes the proceedings of a workshop on "Exclusive and Semi-exclusive Processes at High Momentum Transfer", sponsored by the Institute for Nuclear Theory (Seattle) and the Thomas Jefferson National Accelerator Facility (Jefferson Laboratory). The workshop was inspired by recent progress in the field, particularly in the uses of off-forward or skewed parton distributions to elucidate nucleon structure. This book contains the written versions of 41 scientific talks, on subjects including the aforementioned skewed parton distributions, and also on deeply virtual Compton scattering, semi-exclusive (or semi-inclusive) reactions, and hard elastic and transition form factors.