Recurrent Pregnancy Loss

Dr Sumita Mehta (DGO, DNB, FICOG, MAMS) is a Specialist and heads the Department of Obstetrics & Gynecology at Babu Jagjivan Ram Memorial Hospital, Delhi, India. She is the Secretary of the Indian Society of Colposcopy and Cervical Pathology and a National Expert for the project ECHO (Extension for Community Healthcare Outcomes) at the National Institute of Cancer Prevention & Research. She is an Executive Member and has served as an editor for the Association of Obstetricians & Gynecologists of Delhi. She is on the Editorial board of the journals Heliyon, Journal of Gynecology, and Obstetrics Forecast, and is a reviewer for many international journals. Her special area of interest is in the field of gynecologic oncology, especially cervical cancer. She has conducted several colposcopy workshops throughout India and has delivered numerous lectures at various academic forums. She is the editor of 8 books and has published over 75 articles in national & international journals of repute.  Dr Bindiya Gupta (MD, AIIMS) is presently working as an Assistant Professor at the Department of Obstetrics and Gynecology, UCMS & GTB Hospital, Delhi. She has published over 50 articles in national & international journals and has edited two books. She is presently Editor for the Association of Obstetrician and Gynecologists of Delhi, and an Editorial Board member of the Indian College of Obstetricians and Gynecologists. She was Web Editor of NARCHI 2014-16 and was co-editor of AOGD 2011-12. A reviewer for various international journals, she also serves on the editorial board of two international journals. Her work has been recognized with several awards, including the FIGO best prize paper award from a developing country.

• Background and epidemiology.- Definitions.- Normal implantation, fetal development and placentation.- Normal immune function-  journey of the fetus.- Immunology and pregnancy loss.- Evolving role of genetics in RPL.- Hormonal abnormalities  in women with recurrent losses.- Uterine factors and anatomic considerations.- Antiphospholipid antibody syndrome.- Hereditary thrombophilia.- Microbiology of RPL.- Impact of male factors.- Unexplained recurrent miscarriage: A dilemma.- Psychological factors and stress in RPL.- Evidence based clinical and investigative work up of RPL couples.- Evidence based  management of RPL.- Establishing a one-stop RPL Clinic.- Role of Imaging.- Fetal autopsy and placental examination as a complementary tool.- Inflammatory markers and proteomic analysis.- Emotional support and psychological care of RPL couple.- Pregnancy after RPL.- Future research strategies and directions.- Progestogens/ hCG supplementation: A vital role.- Cervical cerclage: does it help?.- Immunotherapy for recurrent miscarriage.-Preimplantation gentic diagnosis to improve pregnancy outcome.- Termination of failed pregnancy: Surgical vs medical method.- Obesity and its association with RPL.- Minimally invasive surgery: diagnostic and therapeutic role.- Non pharmacologic treatment.