Miyuki AzumaTokyo Medical and Dental University, Grad Sch of Medical and Dental Sciences, JapanHideo YagitaJuntendo University School of Medicine, Dept of Immunology, Japan

• Part I: Basic Understanding of Co-signal Molecules in T cell activation.- Chapter 1            Co-signal molecules in T cell activation.- Chapter 2   The CD28-B7 family of co-signaling molecules.- Chapter 3          The TNF YNFR family of co-signal molecules.- Chapter 4          Signal transduction via co-stimulatory and co-inhibitory receptors.- Chapter 5            Molecular dynamics of co-signal molecules in t cell activation.- Chapter 6    Role of co-stimulatory molecules in T helper cell differentiation.- Chapter 7       Control of regulatory T cells by co-signal molecules.- Part II: Co-signal Molecules in Health and Disease.- Chapter 8            Stimulatory and inhibitory co-signals in autoimmunity.- Chapter 9     Co-signaling molecules in neurological diseases.- Chapter 10       Costimulation blockade in transplantation.- Chapter 11   Immunotherapy targeting co-signal molecules.

Miyuki AzumaTokyo Medical and Dental University, Grad Sch of Medical and Dental Sciences, JapanHideo YagitaJuntendo University School of Medicine, Dept of Immunology, Japan

• Part I: Basic Understanding of Co-signal Molecules in T cell activation.- Chapter 1            Co-signal molecules in T cell activation.- Chapter 2   The CD28-B7 family of co-signaling molecules.- Chapter 3          The TNF YNFR family of co-signal molecules.- Chapter 4          Signal transduction via co-stimulatory and co-inhibitory receptors.- Chapter 5            Molecular dynamics of co-signal molecules in t cell activation.- Chapter 6    Role of co-stimulatory molecules in T helper cell differentiation.- Chapter 7       Control of regulatory T cells by co-signal molecules.- Part II: Co-signal Molecules in Health and Disease.- Chapter 8            Stimulatory and inhibitory co-signals in autoimmunity.- Chapter 9     Co-signaling molecules in neurological diseases.- Chapter 10       Costimulation blockade in transplantation.- Chapter 11   Immunotherapy targeting co-signal molecules.

Miyuki AzumaTokyo Medical and Dental University, Grad Sch of Medical and Dental Sciences, JapanHideo YagitaJuntendo University School of Medicine, Dept of Immunology, Japan

• Part I: Basic Understanding of Co-signal Molecules in T cell activation.- Chapter 1            Co-signal molecules in T cell activation.- Chapter 2   The CD28-B7 family of co-signaling molecules.- Chapter 3          The TNF YNFR family of co-signal molecules.- Chapter 4          Signal transduction via co-stimulatory and co-inhibitory receptors.- Chapter 5            Molecular dynamics of co-signal molecules in t cell activation.- Chapter 6    Role of co-stimulatory molecules in T helper cell differentiation.- Chapter 7       Control of regulatory T cells by co-signal molecules.- Part II: Co-signal Molecules in Health and Disease.- Chapter 8            Stimulatory and inhibitory co-signals in autoimmunity.- Chapter 9     Co-signaling molecules in neurological diseases.- Chapter 10       Costimulation blockade in transplantation.- Chapter 11   Immunotherapy targeting co-signal molecules.