Professor Satoshi Kuroda, MD, PhD, IFAANS Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Science,University of Toyama, Toyama, Japanskuroda@med.u-toyama.ac.jp

• Part I Concept of Moyamoya Disease.- 1 History of Disease Entity & Diagnosis Criteria.- 2 Moyamoya Syndrome.- 3 Unilateral Moyamoya Disease: A Distinct Entity?.- Part II Genetic Aspect of Moyamoya Disease.- 4 RNF213 as Susceptibility Gene.- 5 RNF213 and clinical feature.- 6 RNF213 Variant as a Biomarker of Cerebrovascular Disease.- Part III Pathophysiology of Moyamoya Disease.- 7 TIA & Headache in Pediatric Moyamoya Disease.- 8 Ischemic stroke.- 9 Hemorrhagic Stroke and the Japan Adult Moyamoya Trial.- 10 Cognitive Function in Pediatric Moyamoya Disease.- 11 Cognitive Dysfunction in Adults.- 12 Asymptomatic Moyamoya Disease.- Part IV Update on Neuroradiology in Moyamoya Disease.- 13 Periventricular Anastomosis.- 14 Arterial Shrinkage.- 15 Disease progression.- 16 Postoperative hyperperfusion.- 17 Postoperative FLAIR Imaging Changes.- Part V Real World of Surgical Revascularization for Moyamoya Disease.- 18 Overview of Surgical Revascularization and Long-term Outcome in Japan.- 19 Perioperative complications.- 20 Long-term Outcome in Europe.- 21 Long Term Outcomes in USA.- 22 Long-term Outcome in China.- 23 Long-term outcome of revascularization surgery for moyamoya disease in Korea.- 24 Indirect bypass surgery for moyamoya disease.- 25 Direct/combined bypass surgery.- 26 Special Considerations—Infants.- 27 Special Considerations – Elderly.

Professor Satoshi Kuroda, MD, PhD, IFAANS Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Science,University of Toyama, Toyama, Japanskuroda@med.u-toyama.ac.jp

• Part I Concept of Moyamoya Disease.- 1 History of Disease Entity & Diagnosis Criteria.- 2 Moyamoya Syndrome.- 3 Unilateral Moyamoya Disease: A Distinct Entity?.- Part II Genetic Aspect of Moyamoya Disease.- 4 RNF213 as Susceptibility Gene.- 5 RNF213 and clinical feature.- 6 RNF213 Variant as a Biomarker of Cerebrovascular Disease.- Part III Pathophysiology of Moyamoya Disease.- 7 TIA & Headache in Pediatric Moyamoya Disease.- 8 Ischemic stroke.- 9 Hemorrhagic Stroke and the Japan Adult Moyamoya Trial.- 10 Cognitive Function in Pediatric Moyamoya Disease.- 11 Cognitive Dysfunction in Adults.- 12 Asymptomatic Moyamoya Disease.- Part IV Update on Neuroradiology in Moyamoya Disease.- 13 Periventricular Anastomosis.- 14 Arterial Shrinkage.- 15 Disease progression.- 16 Postoperative hyperperfusion.- 17 Postoperative FLAIR Imaging Changes.- Part V Real World of Surgical Revascularization for Moyamoya Disease.- 18 Overview of Surgical Revascularization and Long-term Outcome in Japan.- 19 Perioperative complications.- 20 Long-term Outcome in Europe.- 21 Long Term Outcomes in USA.- 22 Long-term Outcome in China.- 23 Long-term outcome of revascularization surgery for moyamoya disease in Korea.- 24 Indirect bypass surgery for moyamoya disease.- 25 Direct/combined bypass surgery.- 26 Special Considerations—Infants.- 27 Special Considerations – Elderly.

Professor Satoshi Kuroda, MD, PhD, IFAANS Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Science,University of Toyama, Toyama, Japanskuroda@med.u-toyama.ac.jp

• Part I Concept of Moyamoya Disease.- 1 History of Disease Entity & Diagnosis Criteria.- 2 Moyamoya Syndrome.- 3 Unilateral Moyamoya Disease: A Distinct Entity?.- Part II Genetic Aspect of Moyamoya Disease.- 4 RNF213 as Susceptibility Gene.- 5 RNF213 and clinical feature.- 6 RNF213 Variant as a Biomarker of Cerebrovascular Disease.- Part III Pathophysiology of Moyamoya Disease.- 7 TIA & Headache in Pediatric Moyamoya Disease.- 8 Ischemic stroke.- 9 Hemorrhagic Stroke and the Japan Adult Moyamoya Trial.- 10 Cognitive Function in Pediatric Moyamoya Disease.- 11 Cognitive Dysfunction in Adults.- 12 Asymptomatic Moyamoya Disease.- Part IV Update on Neuroradiology in Moyamoya Disease.- 13 Periventricular Anastomosis.- 14 Arterial Shrinkage.- 15 Disease progression.- 16 Postoperative hyperperfusion.- 17 Postoperative FLAIR Imaging Changes.- Part V Real World of Surgical Revascularization for Moyamoya Disease.- 18 Overview of Surgical Revascularization and Long-term Outcome in Japan.- 19 Perioperative complications.- 20 Long-term Outcome in Europe.- 21 Long Term Outcomes in USA.- 22 Long-term Outcome in China.- 23 Long-term outcome of revascularization surgery for moyamoya disease in Korea.- 24 Indirect bypass surgery for moyamoya disease.- 25 Direct/combined bypass surgery.- 26 Special Considerations—Infants.- 27 Special Considerations – Elderly.