Cancer Genetics and Genomics for Personalized Medicine

Il-Jin Kim is principal investigator and director of Applied Genomics in the UCSF Thoracic Oncology Program. His work focuses on the identification of novel therapeutic targets and diagnostic markers for various types of human cancers. Dr. Kim investigates human cancers using state-of-the-art technologies, including next-generation sequencing (NGS) and system genetic tools that he developed with his team. He has developed several innovative microarrays and pioneered new methods of high-throughput mutation screening, for which he holds numerous patents. He has published more than 70 papers, including in Science and Nature Communications. He has also received three awards from the American Association for Cancer Research for developing innovative genetic and diagnostic assays.

"Likely as the recent Cancer Moonshot Initiative highlights, this book well describes the importance of genetics/genomics-based personalized therapies to improve cancer treatments. This field is growing rapidly, and it is certain that many scientists should obtain professional knowledge of ‘cancer precision medicine’ to cure more cancer patients."—Prof. Yusuke Nakamura, University of Chicago, USA"At a time when an explosive increase in data has combined with rapidly evolving treatment paradigms, it has become particularly challenging for modern clinicians and medical researchers alike to put these advances in knowledge and practice into a proper context. It is in light of this predicament that this new volume edited by Dr. Il-Jin Kim provides a much-needed organization and harmonic understanding to the cacophony of information regarding the elusive realm of precision medicine. Covering an exhaustive array of topics ranging from the basic science of tumor modeling to the biology of tumor microenvironments to the horizon of cancer immunotherapy and advances for specific cancer types, this clearly written and very readable compilation provides a solid foundation for comprehending the rapidly advancing dawn of a truly new, personalized, precision approach to the treatment and, hopefully, the cure of cancer."—Prof. Michael J. Mann, University of California, San Francisco

• Personalized Medicine for Cancer: Introduction and Overview of the Book. Personalized Medicine in Lung Cancer. Genome-Based Personalized Medicine in Liver Cancer. Applications of Circulating DNA Analysis in Personalized Medicine. Circulating Tumor Cells and Personalized Medicine. Mouse Models in Personalized Cancer Medicine. Tumor Microenvironment, Therapeutic Resistance, and Personalized Medicine. Personalized Immune Therapy. Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Peritoneal Malignancies. Personalized Medicine in Hereditary Cancer Syndromes. Pathology in the Era of Personalized Medicine. MicroRNAs in Human Cancers. Pharmacogenomics of Tamoxifen.