This book constitutes the proceedings of the 18th Annual Conference on Theory and Applications of Models of Computation, TAMC 2024, which was held in Hong Kong, China, during May 13–15, 2024. The 30 full papers presented in this book were carefully reviewed and selected from 69 submissions. The main themes of the selected papers are computability, complexity, algorithms, information theory, as well as their integration with machine learning theory and the foundations of artificial intelligence.