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From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment-based discovery, as well as an outlook on where the field is headed.The first part discusses basic considerations of when to use fragment-based methods, how to select targets, and how to build libraries in the chemical fragment space. The second part describes established, novel and emerging methods for fragment screening, including empirical as well as computational approaches. Special cases of fragment-based screening, e. g. for complex target systems and for covalent inhibitors are also discussed. The third part presents several case studies from recent and on-going drug discovery projects for a variety of target classes, from kinases and phosphatases to targeting protein-protein interaction and epigenetic targets.

This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previously unavailable. Adopting a practice-oriented approach, this represents a book by professionals for professionals, tailor-made for drug developers in the pharma and biotech sector who need to keep up-to-date on the latest technologies and strategies in pharmaceutical ligand design. The book is clearly divided into three sections on ligand design, spectroscopic techniques, and screening and drug discovery, backed by numerous case studies.

From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment-based discovery, as well as an outlook on where the field is headed.

The first part discusses basic considerations of when to use fragment-based methods, how to select targets, and how to build libraries in the chemical fragment space. The second part describes established, novel and emerging methods for fragment screening, including empirical as well as computational approaches. Special cases of fragment-based screening, e. g. for complex target systems and for covalent inhibitors are also discussed. The third part presents several case studies from recent and on-going drug discovery projects for a variety of target classes, from kinases and phosphatases to targeting protein-protein interaction and epigenetic targets.

From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment-based discovery, as well as an outlook on where the field is headed.

The first part discusses basic considerations of when to use fragment-based methods, how to select targets, and how to build libraries in the chemical fragment space. The second part describes established, novel and emerging methods for fragment screening, including empirical as well as computational approaches. Special cases of fragment-based screening, e. g. for complex target systems and for covalent inhibitors are also discussed. The third part presents several case studies from recent and on-going drug discovery projects for a variety of target classes, from kinases and phosphatases to targeting protein-protein interaction and epigenetic targets.

The new edition of this indispensable reference features the clinical experience of seasoned experts coupled with fresh perspectives from five new authors, providing you with well-rounded, up-to-date coverage on treating all aspects of nerve injuries. Abundant case studies, descriptive examples of major peripheral nerve injuries and other lesions, and outcome analyses help you implement the most appropriate treatment plan for each individual patient. Plus, the all new full-color design throughout offers exceptional visual guidance on surgical techniques.

This volume brings together established and rising scholars to revitalize political theology by examining conceptions of power that work beyond sovereign power. The hope is to reexamine the character of authority by attending to the multiple, various, but often under-appreciated ways that power is exercised in the contemporary world.

The selection of plants studied in this treatise is based on its significance, and its representation of members of different taxonomic families as well as of different classes (and subclasses) of compounds. All the available data on the chemical compounds and the pharmacological studies on these plants/compounds have been incorporated. The plants are arranged by the type and nature of chemical compounds they contain. Secondary metabolites have been included in this volume due to their great therapeutic role.

This book introduces the reader to a fascinating genre of writings that retell biblical narratives in various ways. They reflect the concerns and methods of early Jewish interpreters of Scripture. Daniel Falk surveys the content and major scholarly issues of three key examples: Genesis Apocryphon (1QapGen), Reworked Pentateuch (4Q158, 364-5), and Commentary to Genesis (4Q252-4). Particular attention is paid to exploring why and how the authors interpret the Scriptural text in their distinctive ways. The book traces continuity and discontinuity with other Jewish and Christian traditions, and reflects on the significance of these texts for the status of Scripture and the boundary between Scripture and interpretation. Drawing on the latest research and reconstructions of the texts, and with extensive bibliographies, this is an authoritative guide for the student or the non-specialist scholar.

This book introduces a quantum-mechanical description of the nuclear fission process from an initial compound state to scission. Issues like the relevant degrees of freedom throughout the process, the way of coupling collective and intrinsic degrees during the fission process, and how a nucleus divides into two separate daughters in a quantum-mechanical description where its wave function can be non-local, are currently being investigated through a variety of theoretical, computational, and experimental techniques.The term “microscopic” in this context refers to an approach that starts from protons, neutrons, and an effective (i.e., in-medium) interaction between them. The form of this interaction is inspired by more fundamental theories of nuclear matter, but still contains parameters that have to be adjusted to data. Thus, this microscopic approach is far from complete, but sufficient progress has been made to warrant taking stock of what has been accomplished so far.Theaim is to provide, in a pedagogical and comprehensive manner, one specific approach to the fission problem, originally developed at the CEA Bruyères-le-Châtel Laboratory in France.Intended as a reference for advanced graduate students and researchers in fission theory as well as for practitioners in the field, it includes illustrative examples throughout the text to make it easier for the reader to understand, implement, and verify the formalism presented.