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From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment-based discovery, as well as an outlook on where the field is headed.The first part discusses basic considerations of when to use fragment-based methods, how to select targets, and how to build libraries in the chemical fragment space. The second part describes established, novel and emerging methods for fragment screening, including empirical as well as computational approaches. Special cases of fragment-based screening, e. g. for complex target systems and for covalent inhibitors are also discussed. The third part presents several case studies from recent and on-going drug discovery projects for a variety of target classes, from kinases and phosphatases to targeting protein-protein interaction and epigenetic targets.

The new edition of this indispensable reference features the clinical experience of seasoned experts coupled with fresh perspectives from five new authors, providing you with well-rounded, up-to-date coverage on treating all aspects of nerve injuries. Abundant case studies, descriptive examples of major peripheral nerve injuries and other lesions, and outcome analyses help you implement the most appropriate treatment plan for each individual patient. Plus, the all new full-color design throughout offers exceptional visual guidance on surgical techniques.

This volume brings together established and rising scholars to revitalize political theology by examining conceptions of power that work beyond sovereign power. The hope is to reexamine the character of authority by attending to the multiple, various, but often under-appreciated ways that power is exercised in the contemporary world.

This book introduces a quantum-mechanical description of the nuclear fission process from an initial compound state to scission. Issues like the relevant degrees of freedom throughout the process, the way of coupling collective and intrinsic degrees during the fission process, and how a nucleus divides into two separate daughters in a quantum-mechanical description where its wave function can be non-local, are currently being investigated through a variety of theoretical, computational, and experimental techniques.The term “microscopic” in this context refers to an approach that starts from protons, neutrons, and an effective (i.e., in-medium) interaction between them. The form of this interaction is inspired by more fundamental theories of nuclear matter, but still contains parameters that have to be adjusted to data. Thus, this microscopic approach is far from complete, but sufficient progress has been made to warrant taking stock of what has been accomplished so far.Theaim is to provide, in a pedagogical and comprehensive manner, one specific approach to the fission problem, originally developed at the CEA Bruyères-le-Châtel Laboratory in France.Intended as a reference for advanced graduate students and researchers in fission theory as well as for practitioners in the field, it includes illustrative examples throughout the text to make it easier for the reader to understand, implement, and verify the formalism presented.