A. Abell - Böcker
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2 produkter
2 produkter
Del 1 - Advances in Amino Acid Mimetics and Peptidomimetics
Advances in Amino Acid Mimetics and Peptidomimetics
Inbunden, Engelska, 1997
1 105 kr
Skickas inom 7-10 vardagar
Peptidomimetics are compounds which mimic the biological activity of peptides while offering the advantages of increased bioavailability, biostability, bioefficiency, and bioselectivity against the natural biological target of the parent peptide. Examples of peptidomimetics have been isolated as natural products, synthesized as libraries from novel subunits, and designed on the basis of X-ray crystallographic studies and through an intricate knowledge of the biological mode of action of natural peptides. They offer challenging synthetic targets and are increasingly important medicinal agents and biological probes. As a consequence, peptidomimetics embrace much of what is modern medicinal and organic chemistry. This volume highlights some recent and exciting developments in the area.
Del 2 - Advances in Amino Acid Mimetics and Peptidomimetics
Advances in Amino Acid Mimetics and Peptidomimetics
Inbunden, Engelska, 1999
1 496 kr
Skickas inom 5-8 vardagar
Peptidomimetics have found wide application as bioavailable, and often potent mimetics of natural peptides. They form the basis of important classes of enzyme inhibitors, they act as receptor agonists and antagonists, and they have even been used to mimic DNA structure. Recent advances in the use of solid-phase organic synthesis have paved the way for the preparation of libraries of these structures to allow the rapid optimization of theri biological properties and hence therapeutic potential. We are also beginning to gain a greater understanding of the structural features of this class of compounds that influence their ability to permeate membranes, and their rate of clearance and metabolism. This volume brings together many of these critical issues by highlighting recent advances in a number of core peptidomimetic-based research.