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557 kr
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In July 1978 a group met in Aberdeen to discuss the whole range of new proteins recently isolated from the human placenta. With the exception of Yuri Tatarinov all the main pioneers in the field were present, and this book arose from the discussions which took place. Each author was asked to bring a written man uscript corresponding to but not necessarily identical with their verbal presentation. Nobody was given a specified remit, for the reason that the subject is so new that it would be impossible to design the meeting or the book in advance. Each speaker was left free to put on display whatever he thought was interesting or important about the newly isolated proteins. Inevitably this has led to much overlap, since everybody tends to follow the same path at first. Nevertheless, we shall probably never achieve so much agreement again. Only Vernon Stevens was set a fixed title out side the immediate field of new placental proteins. This arose from the very exciting possibility that the new proteins could be used to induce an autoimmune state to products of conception and thus serve as the basis for a new method of contraception. There are few findings at present which bear specifically on this proposal, but the experience of Vernon Stevens with hCG could serve as a model of the problems that might be encountered with SP and PAPP-A.
557 kr
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Biochemical tests of fetal well-being ('placental function tests') have been part of routine obstetric practice for more than twenty years. This book provides an overview of the current status of these tests - the physiological basis for their use, and their advantages and limitations in clinical practice. Considerable attention is given to interpretation, a subject which in the past has led to much confusion both in the scientific literature and in the minds of clinicians. Recent advances are described in detail, in particular the discovery of a whole new generation of placental products some of which offer great promise in the prediction of conditions, such as placental abruption and premature labour, which cannot be identified by any other current parameters. Finally, a set of clear recommendations is put forward for the choice of test in most of the common complications of both early and late pregnancy. The emphasis throughout is on how the basic biology of fetoplacental products dictates their use and interpretation in pathological conditions.