A. M. Buchan - Böcker

The maturation phenomenon, first described by Ito et al. in 1975, refers to postischemic changes that develop hours or days after an ischemic insult. The delayed neuronal death of CA1 pyramidal cells of the hippocampus is a classic example. The report of the phenomenon boosted research in the field, as it became evident that ischemic damage is not a sudden event, but a process potentially susceptible to therapeutic intervention. Since then a growing number of studies have improved our knowledge on mechanisms of cell death and recovery. This volume contains the presentations of the Fifth International Workshop on Maturation Phenomenon in Cerebral Ischemia, held in Banff, Alberta, Canada, in April/May 2002. It outlines the present status of investigations and provides further stimulation for research in this field.