Alexander Dömling – författare
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2 produkter
2 produkter
Del 56 - Methods & Principles in Medicinal Chemistry
Protein-Protein Interactions in Drug Discovery
Inbunden, Engelska, 2013
1 839 kr
Skickas inom 11-20 vardagar
Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and computational methods for their investigation. The main part of the book describes examples of protein targets for which small molecule modulators have been developed, covering such diverse fields as cancer, autoimmune disorders and infectious diseases. Tailor-made for the practicing medicinal chemist, this ready reference includes a wide selection of case studies taken straight from the development pipeline of major pharmaceutical companies to illustrate the power and potential of this approach. From the contents: * Prediction of intra- and inter-species protein-protein interactions facilitating systems biology studies* Modulators of protein-protein interactions: The importance of Three-Dimensionality* Interactive technologies for leveraging the known chemistry of anchor residues * SH3 Domains as Drug Targets* P53 MDM2 Antagonists: Towards Non Genotoxic Anticancer Treatments* Inhibition of LFA-1/ICAM interaction for treatment of autoimmune diseases* The PIF-binding pocket of AGC kinases* Peptidic inhibitors of protein-protein interactions for cell adhesion receptors* The REPLACE Strategy for generating Non-ATP competitive Inhibitors of Cell-Cycle Protein Kinases and more
1 069 kr
Kommande
Written by one of the world's leading experts in the field, this is the only book available to adopt a practical approach, presenting the most common and successful experimental procedures used in MCR.As such, the book guides readers through the overwhelming amount of literature and points to the best procedures for gaining optimum results for the attempted synthesis. A small theoretical overview is presented and practical procedures described for each reaction covered. The examples are chosen from drug and natural product synthesis, parallel synthesis as well as drug discovery methods based on virtual screening of MCR-based libraries.With its workable procedures this practical text is perfect for bench chemists working in the pharmaceutical and industrial chemistry, and can equally be used in an advanced organic chemistry or specialized course at universities.