Alexander T. Florence – författare

This unique textbook considers the role of basic pharmaceutics in determining or modifying clinical outcomes and in explaining the behaviour of medicines in the body, including adverse reactions due to formulations and excipients. An Introduction to Clinical Pharmaceutics covers recent developments such as personalised therapies and nanotechnology. All of the principles underpinning clinical pharmaceutics are supported using relevant examples from recent literature and clinical case studies, including issues of: formulation and excipients; surface tension; rheology; solubility; crystallisation and precipitation; aggregation; absorption. Examples and implications of each phenomenon are discussed with a reminder of the underlying pharmaceutics. This book is aimed at undergraduate pharmacy students, those on taught Masters courses of clinical and hospital pharmacy, and new practitioners who require an updating on the relevance of the subject that is virtually unique to pharmacy.

An established textbook that provides you with full coverage of the physicochemical principles essential to the modern pharmacist and pharmaceutical scientist. This sixth edition has a broad chemical and physicochemical base and covers every aspect of drug properties from the design of dosage forms to their delivery by all routes to sites of action in the body. Now with more clinical examples, new questions and extra case studies.

FASTtrack Physical Pharmacy focuses on what you really need to know in order to pass your exams. Concise, bulleted information and all-important self-assessment questions including MCQs. This FASTtrack book is derived from the textbook Physiochemical Principles of Pharmacy and is designed to be used alongside it for those revision periods when time is short. It includes learning objectives, self-assessment questions and memory maps to aid with revision. The fully updated third edition includes new chapters, thus bringing it in line with the sixth edition of Physicochemical Principles of Pharmacy Are your exams coming up? Are you drowning in textbooks and lecture notes and wondering where to begin? Take the FASTtrack route to successful study for your examinations. FASTtrack provides the ultimate lecture notes and is a must-have for all pharmacy students wanting to study and test themselves for forthcoming exams..

With over 100 illustrations, Volume 1 addresses the core disciplines of pharmaceutics (absorption, PK, excipients, tablet dosage forms, and packaging), and explores the challenges and paradigms of pharmaceutics.Key topics in Volume 1 include:• principles of drug absorption, chemical kinetics, and drug stability• pharmacokinetics• the effect of route of administration and distribution on drug action• in vivo imaging of dose forms: gamma scintigraphy, PET imaging NMR, MRI, etc. • powder technology• excipient design and characterization• preformulation• optimization techniques in pharmaceutical formulation and processing• disperse and surfactant systems• the solid state, tablet dosage forms, coating processes, and hard and soft shell capsules• parenteral products

Volume 2 addresses the applications and approaches in advanced drug delivery systems, including transdermal, pulmonary, and ocular routes. In addition, this text discusses the impact of the shift to personalized medicines in the fields of pharmaceutical biotechnology, pharmacogenomics, and nanotechnology.Volume 2 investigates:• sustained- and controlled-release drug delivery systems• bioequivalence• cutaneous and transdermal delivery processes and systems• design and evaluation of ophthalmic pharmaceutical products• delivery of drugs by the pulmonary route• pediatric pharmaceutics and formulation• biotechnology-based pharmaceuticals• veterinary pharmaceutical dosage forms• target-oriented drug-delivery systems and modern evaluation• techniques for medicinal products• aspects of pharmaceutical physics and nanotechnology

This new edition brings you up-to-date on the role of pharmaceutics and its future paradigms in the design of medicines. Contributions from over 30 international thought leaders cover the core disciplines of pharmaceutics and the impact of biotechnology, gene therapy, and cell therapy on current findings. Modern Pharmaceutics helps you stay current with the basic sciences, systems, applications, and advances in drug development—from materials used in formulations and dosage form design and manufacture, to testing in clinical trials.Improve research and development strategies with brand new content on:• methods of in vivo imaging of dosage forms• excipients, tablets, and aerosols—from physical chemistry to dosage form• solid state drug delivery• biotechnology-based pharmaceuticals • modern evaluation techniques for medicinal products • pharmaceutical nanotechnology • pharmaceutical physics • pediatric and geriatric medication • routes of administration • paradigms in pharmaceutical research

'nle NATO Advanced studies Institute series "Targeting of Drugs" was originated in 1981. It is now a major international forum, held every two years in cape Sounion, Greece, in which the present and the future of this important area of research in drug delivery is discussed in great depth. Five previous ASIs of the series dealt with drug carriers of natural and synthetic origin, their interaction with the biological milieu, with ways by which the latter influences such interaction and strategies by which milieu interference curtailing the ftmction of drug carriers is circumvented or relieved. 'nle present book contains the proceedings of the 6th NATO ASI "Targeting of Drugs: 'nle nias who, as chairperson of the Local Corrmittee, contriruted to the success of the Institute. 'nle ASI was held under the sponsorship of NATO Scientific Affairs Division and co-sponsored and generously financed by SmithKline Beecham Phannaceuticals (King of Prussia). Financial assistance was also provided by Syntex Laboratories Inc. (Palo Alto), Syntex Research (Palo Alto) and pfizer Central Research (Sandwich).