Alfred T. Blomquist – författare

Organic Chemistry, Volume 30: Total Synthesis of Steroids provides an overall view of steroid total synthesis, including the general approaches, special problems, stereochemical complexities, expansion or contraction of rings, and insertion of hetero atoms. The book discusses the process of designing total syntheses; the biogenetic-like steroid synthesis, including cyclization of terminal epoxides as well as the total synthesis from nonepoxide precursors; and the synthesis of equilenin, estrone, bisdehydrodoisynolic acid, 18,19-bisnorprogesterone, 19-norpregnanes, and heterocyclic steroids. The text also describes the application of ABD intermediates in the Torgov synthesis; the synthesis of carbocyclics and thiasteroids; and the synthesis from p-anisylcyclohexanes and from C-5, C-8 bridged intermediates. The synthesis based on the type of reaction used in the condensation of the A fragment with the CD portion, as well as the methods of total synthesis in the preparation of 8-azasteroids and 8,13-diazasteroids are also considered. The book further tackles the synthesis of epiandrosterone, cortisone, aldosterone, 3β-hydroxy-5α-pregnan-20-one, latifoline, conessine, and ring C aromatic steroids; the synthesis of trans-benzohydrindane derivatives and other common derivatives; and the synthesis of CD intermediates. Chemists, biochemists, and people involved in the study of steroid total syntheses will find the book invaluable.

Organic Chemistry, Volume 37: Reactions of Organosulfur Compounds covers the basics of organosulfur chemistry and the characteristics of organically bound sulfur, with an emphasis on reactions, particularly those of synthetic utility. The book discusses the preparation, nature, stereochemical aspects, reactions, and the kinetic and thermodynamic assessment of the stability of sulfur-containing carbanions; the preparation and reactions of sulfur ylides; and the preparation, assessment of stability, and reactions of sulfur-containing carbocations. The text also describes preparation, assessment of stability, nature, and reactions of sulfur-containing radicals, organosulfur carbenes, and carbenoids; as well as the the pericyclic reactions of organosulfur compounds. Chemists, biochemists, and students taking related courses will find the book useful.

The Chemistry of Pyrroles, Volume 34 aims to provide a comprehensive survey of the synthesis of simple pyrroles and to present, wherever possible, a mechanistic and theoretical rationale for the multitude of reactions known for pyrroles. The book discusses the structure and reactivity of pyrrole; the synthesis of the pyrrole ring; and the electrophilic substitution of the pyrrole ring. The text also describes the oxidation and reduction of the pyrrole ring; the rearrangement and addition reactions; and the ketones, aldehydes, and carboxylic acid derivatives of pyrrole. Alkylpyrroles and related compounds; hydroxy- and aminopyrroles and related compounds; and azafulvenes are also considered. The book further tackles the physico-organic properties of pyrrole. Chemists and researchers of pyrrole chemistry will find the text invaluable.

Anodic Oxidation covers the application of the concept, principles, and methods of electrochemistry to organic reactions. This book is composed of two parts encompassing 12 chapters that consider the mechanism of anodic oxidation. Part I surveys the theory and methods of electrochemistry as applied to organic reactions. These parts also present the mathematical equations to describe the kinetics of electrode reactions using both polarographic and steady-state conditions. Part II examines the anodic oxidation of organic substrates by the functional group initially attacked. This part particularly emphasizes the kinds of intermediates generated and the mechanisms leading to final products. This book is intended primarily to organic chemists and physical electrochemists.

Organic Functional Group Preparations, Volume III describes 13 organic functional groups and presents a critical review of their available methods of synthesis with preparative examples of each. The book puts special attention to the presentation of specific laboratory directions for the many name reactions used in describing the synthesis of these functional groups. Each chapter deals with the preparation of a given functional group by various reaction types (condensation, elimination, oxidation, reduction) and a variety of starting materials. Acetals and ketals, anhydrides, and thiohydroxamic acids are some of the organic functional groups described in the text. Organic chemists will find the book invaluable.

Organic Functional Group Preparations, Volume II describes 17 organic functional groups and presents a critical review of their available methods of synthesis with preparative examples of each. The book puts special attention to the presentation of specific laboratory directions for the many name reactions used in describing the synthesis of these functional groups. Each chapter deals with the preparation of a given functional group by various reaction types (condensation, elimination, oxidation, reduction) and a variety of starting materials. Ynamines, enamines, allenes, and N-nitroso compounds are some of the organic functional groups described in the text. Organic chemists will find the book invaluable.