Ali Akbar Velayati – författare

Atlas of Mycobacterium Tuberculosis reveals in-depth information about mycobacterium tuberculosis which has never before been reported. Using atomic force microscopy (AFM), the in-depth phenotypic interaction that occurs in different stages of the tuberculosis lifecycle is illustrated, including resting, exponential, and dormant states.

Coverage also includes the macroscopic and microscopic anatomy of mycobacterium, including pigmentation, morphology of colonies, size and shape, and the phenotypic changes from susceptible to resistant, all shown with images from electronic and atomic force microscopes.

This book will open a new window into the results of molecular changes at the cellular level, guiding researchers and scientists to think in new ways about the area of cell wall and the reproductive and drug resistance phenomena surrounding tuberculosis.

Identifies the different stages and morphological aspects of mycobacterium tuberculosis with the use of new microscopy techniques Includes never-before-seen photographs from the personal collection and scientific achievement of the authors Outlines the nature of the lifecycle of mycobacterium tuberculosis in relation to adaptation in humans

Nontuberculous Mycobacteria (NTM): Microbiological, Clinical and Geographical Distribution is a complete reference that stimulates a greater understanding of NTM infections. Sections cover microbiologic and molecular diagnostic tools, drug susceptibility tests, human genetic susceptibility, prevalence and incidence studies, clinical and radiological presentations, and clinical trials for antibiotic therapy. With the incidence rate of NTM infections increasing globally during the last decade, significant mortality and morbidity must be addressed. This important reference will provide research scientists, clinical microbiologists, hospital diagnostic technicians, and post graduate medical and science students with information on the epidemiology, prevalence, microbiology and clinical aspects of NTM.

Highlights new findings in the epidemiological distribution and new diagnosis and treatment protocol of mycobacterial infections Debates new advances in the detection of NTM Demonstrates the distribution of NTM in the environment and its relationship with human infection using a geographical information system (GIS) Includes new radiological findings in non-tuberculous mycobacterial infections in the lung using CT and PET-Scan imaging

Hospitalization, Diagnosis, Treatment, and Surgery: The Lifecycle of Medical Sciences in Iran provides a complete understanding of the lifecycle of medicine in the underserved area of Iran. Coverage will elucidate the importance of communication between scientists in different countries for the further development of research to advance hospitalization infrastructure, diagnosis and treatment of diseases, and surgery techniques and availability.

Using a systematic timeline approach, coverage includes early medical sciences to present day of Iran. Each chapter highlights important research, techniques, and procedures throughout the lifecycle of medical sciences and includes topics from bloodletting and setting bones, to anesthesia and vaccines. The content in each chapter emphasizes standard protocols based on international recognition to help developing countries adopt newer technologies.

Covers the lifecycle of medical sciences in Iran for a comprehensive introduction to the developments in hospitalization, diagnosis and treatment of diseases, and surgery Shows ways that modern technology can be utilized in underserved areas of the world Provides the unique perspective and insight into the diagnosis and treatment of infectious diseases like M. tuberculosis from a country that has seen the progression of the disease and its available treatments over many years

Pili in Mycobacterium Tuberculosis: Structure, Function, and Therapeutic Advances discusses the types of pili produced by the tuberculosis-causing bacterium, Mycobacterium tuberculosis (MTB). The book examines the structure of pili shown under electron and atomic force microscopy and, by using whole genome sequencing, outlines the importance of pili in MTB. It also explores the role of pili in bacteria-host interactions and in drug development and delivery.The book provides an overview of the structure, synthesis, and function of pili in bacteria. This includes taxonomy and the role of pili in diseases. It also examines the structure of pili and the preparation of MTB for electronic and atomic microscopy. It explores the various life cycles of pili, the susceptibility patterns of MTB, the differences of pili formation in MTB, and their role in increase surveillance. It goes on to discuss the expression and function of pili using whole genome sequencing and PCR-based methods and delves into bacteria-host interactions. Lastly, it explores the development of new drugs and their therapeutic delivery by pili.Covers the structure, synthesis, and function of pili produced by the tuberculosis-causing bacterium, MTBIntroduces seven types of pili in MTBExplains the mechanism of bacteria-host attachment and importance of this phenomena in MTB pili and other bacteriaEmphasizes the use of advances techniques to study and investigate the TB-bacilli and its interaction with host cells

Structural and Functional Dynamics of Nontuberculous Mycobacterium Proteins: Insights into Pathogenic Mechanisms explores the structural and functional dynamics of nontuberculous mycobacterium (NTM) proteins, focusing on their roles in pathogenicity, the mechanisms underlying microbial infections, and the potential for developing targeted therapeutic strategies to combat these emerging pathogens. The book begins with a foundational overview of nontuberculous mycobacteria (NTM), distinguishing them from Mycobacterium tuberculosis, their epidemiology, clinical significance, and structural biology. It discusses key structural features of NTM proteins and advanced techniques for protein structure determination, proteomic analyses, and bioinformatics approaches.Additional sections investigate the pathogenic mechanisms and the complexities of the host-pathogen interaction. Concluding with insights into emerging research, interdisciplinary collaboration, future treatment, and prevention strategies, this book is a helpful resource for researchers and healthcare professionals engaged in the study of infectious diseases.Examines the structures of key proteins from nontuberculous mycobacteria, highlighting functional domains and binding sites essential for understanding how these bacteria cause diseaseAnalyzes interactions between nontuberculous mycobacteria and host cells to reveal the mechanisms of immune evasion and infectionInvestigates potential therapeutic targets to help develop treatments to combat infections caused by nontuberculous mycobacteriaAddresses the growing challenge of antibiotic resistance by comparing mechanisms across slow and rapid-growing mycobacteria

This book presents an unprecedented exploration of the protein landscape and structural biology of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), a persistent global health crisis. It carefully differentiates Mtb proteins and their subclasses, along with associated byproducts, to deepen our understanding of the physiological variations within M. tuberculosis under diverse conditions and to drive the development of innovative treatment strategies.Organized by the functional roles of proteins, the chapters reveal how individual proteins can perform multiple functions depending on the environmental context, highlighting the bacterium’s remarkable adaptability. The book systematically examines the contributions of surface and secreted proteins, metabolic enzymes, efflux pumps, pili, and proteins essential during both exponential growth and persistence phases of the Mtb life cycle. Special focus is given to novel protein targets involved in carbon, nitrogen, and iron–sulfur cluster assembly, as well as proteins with complex domain architectures known for their roles in immune modulation and antigenic variation. Additionally, it addresses protein alterations linked to drug resistance and discusses how structural dynamics and domain combinations influence resistance mechanisms and therapeutic vulnerabilities. By mapping these essential and species-specific proteins, the book emphasizes their potential as therapeutic targets to combat multidrug-resistant and extensively drug-resistant TB. It integrates computational, structural, and experimental approaches for protein target identification and validation, supporting the discovery of new inhibitors and combination therapies.This comprehensive resource is invaluable for researchers, clinicians, and students in microbiology and infectious disease, offering foundational insights and cutting-edge research to guide future understanding of M. tuberculosis physiology under varying conditions and to inform novel treatment approaches.