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Innovations and Emerging Technologies in Wound Care is a pivotal book on the prevention and management of chronic and non-healing wounds. The book clearly presents the research and evidence that should be considered when planning care interventions to improve health related outcomes for patients. New and emerging technologies are discussed and identified, along with tactics on how they can be integrated into clinical practice. This book offers readers a bridge between biomedical engineering and medicine, with an emphasis on technological innovations. It includes contributions from engineers, scientists, clinicians and industry professionals.

Users will find this resource to be a complete picture of the latest knowledge on the tolerance of human tissues to sustained mechanical and thermal loads that also provides a deeper understanding of the risk for onset and development of chronic wounds.

The Science, Etiology and Mechanobiology of Diabetes and Its Complications presents the most comprehensive synthesis of contemporary global research on diabetes, covering a novel and unique mechanobiological perspective - addressing prevention, management and treatment of tissue, organ and body system damage associated with diabetes and its complications. The book provides a unique approach to communicating diabetes-associated symptoms and opens avenues for development of novel therapeutic and preventive methods. It offers descriptive pathophysiology of diabetes and its complications with great emphasis on mechanobiology. Content coverage also includes management of tissue, organ and body system damage caused by chronic hyperglycemia.

Biologists, life scientists, physicians, pharmacists, biomedical engineers, medical physicists, biomathematicians and computer scientists who are interested in the state-of-science and current challenges in the mechanobiology of diabetes should find this book very useful. Likewise, medical researchers in fields such as endocrinology, cardiovascular medicine, oncology, obesity, the immune system, inflammation and wound care and others who wish to be updated about the latest achievements in this exciting arena of research will find that information here.

Applied Science and Engineering of Wound Dressings and their Clinical Effectiveness: From Design Principles to Physiological Performance addresses the measurable physical, chemical, biomaterial, fluid structure, mechanical and thermal characteristics that are imperative for a dressing to effectively treat acute and chronic wounds. Divided into two parts, the book discusses the properties of wound dressings, their structure, and how they interact with skin surfaces based on scientific investigation and testing. It also discusses potential tradeoffs, including associated costs of manufacturing, clinical performance characteristics of a dressing, e.g., ease of application and removal, the ability of the dressing to stay in place, and more.This book will be valuable for all professionals involved in the treatment of all types of wounds, including biomedical engineers, material scientists, clinicians across all the relevant medical disciplines, industrialists and regulatory professionals in the field of wound care, academics, scientists and entrepreneurs in the field of medical devices, and undergraduate and graduate bioengineering and medical engineering students who are interested in the structure and function of wound dressings.

This updated volume provides the current knowledge on the diagnosis, treatment, management, and prevention of pressure ulcers. Chapters on the early detection of pressure ulcers, negative pressure therapy, pressure ulcers in pediatric patients, adjunctive therapies, surgical management of pressure ulcers, and innovation in pressure ulcer research and practice are included.

This second edition aims to be the primary reference for pressure ulcers from diagnosis and prevention to management and treatment options.

The book is relevant to dermatology clinicians, vascular surgeons, and dermatology nurses.

This volume describes the state-of-knowledge in the study of the relationships between mechanical loading states in tissues and common pathophysiologies related to increase in mass of adipose tissues and/or hyperglycemia which eventually lead to obesity, diabetes, insulin resistance, hyperlipidemia, metabolic inflammations, certain types of cancer and other related diseases.

There appears to be an interaction between the loading states in tissues and cells and these chronic conditions, as well as with factors such as age, gender and genetics of the individual. Bioengineering has made key contributions to this research field in providing technologies for cell biomechanics experimentation, microscopy and image processing, tissue engineering and multi-scale, multi-physics computational modeling. Topics at the frontier of this field of study include: the continuous monitoring of cell growth, proliferation and differentiation in response to mechanical factors such as stiffness of the extracellular matrix (ECM) and mechanical loads transferred through the ECM; mechanically-activated signaling pathways and molecular mechanisms; effects of different loading regimes and mechanical environments on differentiation fates of mesenchymal stem cells (MSCs) into myogenic and osteogenic versus adipogenic lineages; the interactions between nutrition and mechanotransduction; cell morphology, focal adhesion patterns and cytoskeletal remodeling changes in adipogenesis; activation of receptors related to diabetes by mechanical forces; brown and white adipose plasticity and its regulation by mechanical factors.

Pressure-related chronic wounds are an important health concern that affects millions of patients and accumulates billions in annual costs. These wounds may occur when soft tissues are mechanically compressed between bony prominences and a supporting surface. This book gives a complete and quantitative explanation of the mechanobiology which causes chronic wounds. The reviews give an overall picture on all length scales of the phenomenon, starting from musculoskeletal biomechanics to the modeling of soft tissues and their interaction with bones. At the microscopic levels, it thoroughly reviews experiments and modeling of cellular forces and molecular processes that occur during injury and healing, including the integrity of living cells subjected to sustained mechanical forces and deformations. The results allow a complete picture of the tolerance of human tissues to sustained loads, and an understanding of the risk for onset of chronic wounds. Hence, this book is also valuable for all professionals involved in the prevention and treatment of chronic wounds.