Ananda Chakrabarty – författare

Explores current and emerging applications of microbes as cancer-fighting agents

WILEY SERIES IN BIOTECHNOLOGY AND BIOENGINEERING Anurag S. Rathore, Series Editor

Today, treatment options for cancer patients typically include surgery, radiation therapy, immunotherapy, and chemotherapy. While these therapies have saved lives and reduced pain and suffering, cancer still takes millions of lives every year around the world. In recent years, researchers have been working on a new strategy: developing microbes and microbial products that specifically attack cancer cells.

This book breaks new ground in emerging cancer treatment modalities by presenting recent advances in the use of microorganisms and viruses as well as their products in cancer therapy. Seventeen chapters review the application of live microorganisms, high and low molecular weight products derived from microorganisms, and microbial products fused to cancertargeting molecules. In addition, the book highlights the benefits of a multi-target approach to destroy cancer cells. Readers will not only discover the results and significance of basic and clinical research, but also encouraging results from clinical trials.

Emerging Cancer Therapy is divided into three sections:

With chapters written by leading pioneers in microbial, biotech, and cancer research, Emerging Cancer Therapy is recommended for biotechnologists, microbiologists, clinical oncologists, medicinal chemists, and biochemists. Readers will not only learn the tremendous potential of microbial and biotechnological approaches to cancer therapy, but also discover new directions of research for effective drug discovery and development.

Explores current and emerging applications of microbes as cancer-fighting agents

WILEY SERIES IN BIOTECHNOLOGY AND BIOENGINEERING Anurag S. Rathore, Series Editor

Today, treatment options for cancer patients typically include surgery, radiation therapy, immunotherapy, and chemotherapy. While these therapies have saved lives and reduced pain and suffering, cancer still takes millions of lives every year around the world. In recent years, researchers have been working on a new strategy: developing microbes and microbial products that specifically attack cancer cells.

This book breaks new ground in emerging cancer treatment modalities by presenting recent advances in the use of microorganisms and viruses as well as their products in cancer therapy. Seventeen chapters review the application of live microorganisms, high and low molecular weight products derived from microorganisms, and microbial products fused to cancertargeting molecules. In addition, the book highlights the benefits of a multi-target approach to destroy cancer cells. Readers will not only discover the results and significance of basic and clinical research, but also encouraging results from clinical trials.

Emerging Cancer Therapy is divided into three sections:

With chapters written by leading pioneers in microbial, biotech, and cancer research, Emerging Cancer Therapy is recommended for biotechnologists, microbiologists, clinical oncologists, medicinal chemists, and biochemists. Readers will not only learn the tremendous potential of microbial and biotechnological approaches to cancer therapy, but also discover new directions of research for effective drug discovery and development.

Cancer threatens the lives of people around the world. Women, in particular, are at risk of certain cancers with a genetic cause. Certain mutations in the BRCA1 and BRCA2 genes put mothers and daughters at risk of breast and ovarian cancers. Unlike many cancers that most commonly occur after age 60, these inheritable cancers threaten women’s lives, health and fertility even when they are young, before most would even begin to go for annual mammogram screenings to check for breast cancer.

Three Daughters, Three Journeys takes on the biggest health issue of our time from a global perspective with three heroines fighting for their lives against cancer. Marzena, a Polish oncology nurse, has spent her life treating child patients with cancer. Then, she confronts it in her own family and her own body. Kamola, a rural Indian girl, knows she has symptoms of the same disease that took her mother, but feels afraid to discuss it with her father and brothers, knowing her family cannot afford medical treatment. Kamola confides in Dr Rini Mishra, a doctor testing a new treatment called Neelazin, using a bacterial anticancer protein in food, to destroy cancer cells. Selena, a wealthy woman of color in Chicago, finds out about her genetic risks of breast and ovarian cancer. She has a choice of preventative surgery that will save her life but remove any chance of having children. As she meets women who struggle to afford cancer treatment, Selena dedicates her life to providing affordable homes and counseling to families affected by the disease.

Although the drug Neelazin is fictional, the possibility of new cancer treatments using bacterial anticancer proteins is being researched now. A problem with the current chemotherapy for cancer treatment is the high toxicity of most of these drugs, as these drugs can enter both normal and cancer cells, though preferably cancer cells, causing the death of normal cells as well that are important in maintaining health. Another problem is that current chemotherapeutic drugs mostly target a single or few key steps that are important for cancer growth and proliferation and inhibit the growth of cancer cells. The cancer cells respond by quickly changing these single targets, thereby becoming resistant to the drugs, as is reflected in stage IV cancer patients. An alternative to chemotherapy would be to exploit the bacterial evolutionary wisdom and use certain proteins that can have preferential entry to cancer cells in order to minimize normal cell toxicity and multiple targets in cancer cells through protein–protein complex formation, thus reducing resistance development in cancer cells. An interesting advantage of protein drugs is to express them as part of food, and some recent research seems to suggest that oral consumption of such foods may allow the therapeutic protein to reach the blood stream to target the cancer. Women with the genetic risk factors could soon have the choice of taking a pill or such anticancer protein-expressing food to treat or prevent cancer, rather than removing the healthy tissue of the breasts and ovaries. Hopefully, they would not have to choose between fertility and survival, as is the implied message in this book, fictional as it is at this time.

Cancer threatens the lives of people around the world. Women, in particular, are at risk of certain cancers with a genetic cause. Certain mutations in the BRCA1 and BRCA2 genes put mothers and daughters at risk of breast and ovarian cancers. Unlike many cancers that most commonly occur after age 60, these inheritable cancers threaten women’s lives, health and fertility even when they are young, before most would even begin to go for annual mammogram screenings to check for breast cancer.

Three Daughters, Three Journeys takes on the biggest health issue of our time from a global perspective with three heroines fighting for their lives against cancer. Marzena, a Polish oncology nurse, has spent her life treating child patients with cancer. Then, she confronts it in her own family and her own body. Kamola, a rural Indian girl, knows she has symptoms of the same disease that took her mother, but feels afraid to discuss it with her father and brothers, knowing her family cannot afford medical treatment. Kamola confides in Dr Rini Mishra, a doctor testing a new treatment called Neelazin, using a bacterial anticancer protein in food, to destroy cancer cells. Selena, a wealthy woman of color in Chicago, finds out about her genetic risks of breast and ovarian cancer. She has a choice of preventative surgery that will save her life but remove any chance of having children. As she meets women who struggle to afford cancer treatment, Selena dedicates her life to providing affordable homes and counseling to families affected by the disease.

Although the drug Neelazin is fictional, the possibility of new cancer treatments using bacterial anticancer proteins is being researched now. A problem with the current chemotherapy for cancer treatment is the high toxicity of most of these drugs, as these drugs can enter both normal and cancer cells, though preferably cancer cells, causing the death of normal cells as well that are important in maintaining health. Another problem is that current chemotherapeutic drugs mostly target a single or few key steps that are important for cancer growth and proliferation and inhibit the growth of cancer cells. The cancer cells respond by quickly changing these single targets, thereby becoming resistant to the drugs, as is reflected in stage IV cancer patients. An alternative to chemotherapy would be to exploit the bacterial evolutionary wisdom and use certain proteins that can have preferential entry to cancer cells in order to minimize normal cell toxicity and multiple targets in cancer cells through protein–protein complex formation, thus reducing resistance development in cancer cells. An interesting advantage of protein drugs is to express them as part of food, and some recent research seems to suggest that oral consumption of such foods may allow the therapeutic protein to reach the blood stream to target the cancer. Women with the genetic risk factors could soon have the choice of taking a pill or such anticancer protein-expressing food to treat or prevent cancer, rather than removing the healthy tissue of the breasts and ovaries. Hopefully, they would not have to choose between fertility and survival, as is the implied message in this book, fictional as it is at this time.