Anatoly Dritschilo - Böcker

Rhim and Dritschilo's state-of-the-art volume on Neoplastic Transformation in Human Cell Culture highlights the latest findings on the role of carcinogenic agents in the development of human cancers using a variety of human cells as experimental model systems. Chapters cover all the latest results on the transformation of human cells in culture and provide new insight into the molecular and cellular changes that occur during their conversion from normal to neoplastic states. A wealth of topics is presented, including: oncogenes derivation of epithelial, fibroblastic, and hematopoietic in vitro model systems viral transformation factors that trigger or affect cell transformation in vitro model systems for viral, chemical, and radiation carcinogenesis the multistep nature of human carcinogenesis the role of activated and suppressor oncogenes in neoplastic transformation cell aging radiation transformation.Unique in both scope and focus - devoted solely to human cell transformation systems - Neoplastic Transformation in Human Cell Culture provides unparalleled, in-depth coverage for cancer researchers, cell and molecular biologists, hematologists, virologists, and workers in related fields. Essential reading for everyone who needs to be kept up-to-date in this fast-paced area!

The role of carcinogenic agents in the deveolopment of human cancers is now being defined using a variety of human cells as experi­ mental model systems. A workshop on "neoplastic transformation in human cell systems in vitro: mechanisms of carcinogenesis" was held at the Georgetown University Medical Center, Washington, DC, on April 25-26, 1991. The aims of the workshop were to present the state-of-the­ art in the transformation of human cells in culture, as well as to provide insight into the molecular and cellular changes involved in the conver­ sion of normal cells to a neoplastic state of growth. The following topics were closely related to the theme of the workshops: 1. Derivation of in vitro model systems (epithelial, fibroblastic, and hematopoietic). 2. Factors modulating cellular transformation. 3. Usefulness of defined in vitro model systems for viral, chemical, and radiation carcinogenesis. 4. Multistep nature of human cell carcinogenesis. 5. Role of activated and suppressor oncogenes in neoplastic trans­ formation. The workshop was organized by J. S. Rhim and A. Dritschilo (cochairmen), G. Jay, J. little, M. McCormick, R Tennant, and R R Weischelbaum. There were 32 speakers, 30 poster presentations, and about 190 participants.

This book, part contributed volume, part proceedings, discusses state-of-the-art advances on human cell transformation in cell models for the study of cancer and aging. Several of the chapters are from the Human Cell Transformation: Advances in Cell Models for the Study of Cancer and Aging conference that was held in June 2018 at McGill University. The authors represent international expertise on a wide variety of topics ranging from different types of cancer (prostate, bone, breast, etc.) to tumor microenvironment, tumor progression, homogeneity, and possible therapies and treatments.