Andreas Holzenburg - Böcker

Dramatic advances have been made in recent years in the field of redox enzymology which has resulted in an increase of research activities. This volume covers milestone developments in this field by leading experts, uniting theory and experiment, and selecting contributions to illustrate important aspects of the mechanisms of electron and radical transfer in proteins. Features include: a demonstration of the key principles controlling biological redox reactions; experimental studies of "simple" soluble systems in various enzyme familiies to illustrate concepts in the control of electron transfer reactions; and details of advances made in membrane electron transfer through structural descriptions of key membrane-embedded proteins.

Structure-function relationships of human pathogenic viruses provides information on the mechanisms by which viruses enter the cell, replicate, package their DNA into capsids and mature into new virions. In this volume, the relationship between structural features and the pathogenicity and oncogenicity of some of the most relevant human viral pathogens are demonstrated and the acquisition of defense mechanisms through virus-host interactions are presented. In contrast to textbooks, this title combines research data to provide a holistic view of viral pathogenesis.

Antiviral drugs are important tools for treatment or prevention of viral infections. These drugs were first used for monotherapy, but nowadays combinations of antiviral agents are often part of a standard treatment as evidenced by e.g. HAART (highly active antiretroviral therapy). However, in almost every case of antiviral therapy, drug resistant viruses appear. In addition, the low oral bioavailability, toxicity and the number of severe side effects still pose significant problems. All of the latter issues limit the clinical usefulness and drive the need for improved antiviral strategies. These strategies include new drugs and targets, novel modes of action, vector-based treatments and even the block of defined genes by inhibiting mRNA formation (siRNA). Highlights of this book include the discussion of:- novel, promising compounds- concepts of therapy for new/emerging viruses- managing drug resistance- new therapeutic strategiesThis book presents an overview of the most recent developments. Contributions were carefully selected to ensure quality coverage by acknowledged experts over a wide spectrum and should prove to be of great value to students and serve as a compendium for R and D and educational professionals.

Antiviral drugs are important tools for treatment or prevention of viral infections. These drugs were first used for monotherapy, but nowadays combinations of antiviral agents are often part of a standard treatment as evidenced by e.g. HAART (highly active antiretroviral therapy). However, in almost every case of antiviral therapy, drug resistant viruses appear. In addition, the low oral bioavailability, toxicity and the number of severe side effects still pose significant problems. All of the latter issues limit the clinical usefulness and drive the need for improved antiviral strategies. These strategies include new drugs and targets, novel modes of action, vector-based treatments and even the block of defined genes by inhibiting mRNA formation (siRNA). Highlights of this book include the discussion of:- novel, promising compounds- concepts of therapy for new/emerging viruses- managing drug resistance- new therapeutic strategiesThis book presents an overview of the most recent developments. Contributions were carefully selected to ensure quality coverage by acknowledged experts over a wide spectrum and should prove to be of great value to students and serve as a compendium for R and D and educational professionals.

Dramatic advances have been made in recent years in the field of redox enzymology which has resulted in an increase of research activities. This volume will cover the recent milestone developments in this field by leading experts, uniting theory and experiment, and selecting contributions to illustrate important aspects of the mechanisms of electron and radical transfer in proteins. Features: A demonstration of the key principles controlling biological redox reactions; Experimental studies of `simple' soluble systems in various enzyme familiies to illustrate concepts in the control of electron transfer reactions; Detail of advances made in membrane electron transfer through structural descriptions of key membrane-embedded proteins; Appeal to those interested in the design and use of redox enzymes, from academics to industrialists.

Structure-Function Relationships of Human Pathogenic Viruses provides information on the mechanisms by which viruses enter the cell, replicate, package their DNA into capsids and mature into new virions. The relation between structural features and the pathogenicity and oncogenicity of some of the most relevant human viral pathogens are demonstrated and the acquisition of defense mechanisms through virus-host interactions are presented. In contrast to textbooks, this volume combines timely research data to provide a holistic view of viral pathogenesis. Furthermore Structure-Function Relationships of Human Pathogenic Viruses illustrates in a single volume the fundamental processes involved in viral life cycles using up-to-date information from research laboratories around the world. Knowledge of these processes is crucial to develop rationales for the design of future drugs. The timeliness of the data and the comprehensive yet concise approach this book takes in order to present the world of viral pathogens should make it a frontrunner in higher education and R&D.