Ángel Alberich-Bayarri – författare

This book, endorsed by EuSoMII, provides clinicians, researchers and scientists a useful handbook to navigate the intricate landscape of data harmonization, as we embark on a journey to improve the reproducibility, robustness and generalizability of multi-centric real-world data radiomic studies.   

In these pages, the authors delve into the foundational principles of radiomics and its far-reaching implications for precision medicine. They describe the different methodologies used in extracting quantitative features from medical images, the building blocks that enable the transformation of images into actionable predictions. This book sweeps from understanding the basis of harmonization to the implementation of all the knowledge acquired to date, with the aim of conveying the importance of harmonizing medical data and providing a useful guidance to enable its applicability and the future use of advanced radiomics-based models in routine clinical practice.  

As authors embark on this exploration of data harmonization in radiomics, they hope to ignite discussions, foster new ideas, and inspire researchers, clinicians, and scientists alike to embrace the challenges and opportunities that lie ahead. Together, they elevate radiomics as a reproducible technology and establish it as an indispensable and actionable tool in the quest for improved cancer diagnosis and treatment.

This is the first book to cover all aspects of the development of imaging biomarkers and their integration into clinical practice, from the conceptual basis through to the technical aspects that need to be considered in order to ensure that medical imaging can serve as a powerful quantification instrument capable of providing valuable information on organ and tissue properties. The process of imaging biomarker development is considered step by step, covering proof of concept, proof of mechanism, image acquisition, image preparation, imaging biomarker analysis and measurement, detection of measurement biases (proof of principle), proof of efficacy and effectiveness, and reporting of results. Sources of uncertainty in the accuracy and precision of measurements and pearls and pitfalls in gold standards and biological correlation are discussed. In addition, practical use cases are included on imaging biomarker implementation in brain, oncologic, cardiovascular, musculoskeletal, and abdominal diseases. The authors are a multidisciplinary team of expert radiologists and engineers, and the book will be of value to all with an interest in the quantitative imaging of biomarkers in personalized medicine.