Anil Gupta - Böcker

Human Caspases and Neuronal Apoptosis in Neurodegenerative Diseases elucidates elaborately the role of caspase enzymes implicated in the initiation of molecular events leading to neuronal apoptosis in the neurodegenerative disease. The book starts with introduction to neuropathology, neurogenetics, and epidemiology of neurodegenerative disease and illustrates the involvement of human caspases, neuronal apoptosis, apoptotic pathways, genetic polymorphisms, and several other factors and underlying mechanisms in the pathology of Alzheimer's disease, Parkinson's disease, and Huntington's disease. An important focus in all chapters is the intricate mechanisms and interplay that occur during or leading to neuron death in neurodegenerative diseases, along with disease pathobiology. Provides in-depth knowledge about neurotoxic potential of transition metals, impaired mitochondrial dynamics in the brain neurons, mutant proteins A? peptide, tau protein, ?-synuclein, huntingtin protein and formation of Lewy bodies, reactive oxygen and nitrogen species, ubiquitin proteasome dysregulation, and many others in neurodegenerative diseases Elucidates neurogenetics of gene APP, gene PSEN1,?gene APOE, gene LRRK2, gene DJ1, and others in the pathology of neurodegenerative diseases Explains caspases-mediated neuronal apoptosis in pathogenesis of Alzheimer's disease covering amyloidogenesis, caspase-activated DNase, rho-associated coiled coil-containing protein kinase 1, mammalian sterile 20-like kinase 1, role of synaptic loss, microglial TREM2 receptor, microglial LRP1 receptor, microglial advanced glycation end-product receptor, astrocytic glial ? 7 subtypes of nAChR, NLRP3 inflammasome, P2X purinoreceptors, miRNAs, and many other factors Demonstrates the role of caspases and apoptosis in Parkinson's disease covering truncation of ?-synuclein, neuroinflammation, parkin protein, activation of microglial cells, extrinsic and intrinsic pathways of apoptosis, ?tau314, and several other factors Explains etiopathogenesis of Huntington's disease through covering clinically important topics as role of exon 1 HTT protein, ubiquitous nature of huntingtin, length of expanded polyglutamine tract, classically and alternately activated microglia, nuclear factor kappa B, kynurenine signaling pathway, tumor suppressor protein, PGC-1? gene, advanced glycation end-products, autophagy, and many other significant topics

Understanding Insulin and Insulin Resistance is written in a simple and clear language illustrated with diagrams that show the complex interplay of various factors in the initiation of insulin resistance. The design is systematic and meticulous, portraying topics in a flow from simple to complex. This resource is intended for a broad audience spanning across biochemistry, medicine, dentistry, academia, physicians, and research scholars. It extends the approach to biochemistry, physiology, metabolism of insulin along with the coverage of pathophysiology of insulin resistance, its effects on the body tissues, and its analysis on insulin resistance syndrome. Provides exhaustive and latest knowledge related to the chronology of diabetes mellitus, different phases in the discovery of insulin, contribution of several workers in discovery of insulin, insulin structure, types of insulin, and role of latest insulin delivery devices including various transdermal insulin delivery devices and bionic pancreas in the management of diabetes mellitus Delivers extensive and current information relevant to structure of insulin gene, role of insulin gene-variable number of tandem repeats, insulin two genes versus single gene system, role of wide array of promoters, transcription factors, hormones and nutrients in the regulation of transcription of insulin gene speckled with description of dysregulation of insulin gene transcription by glucotoxicity, lipotoxicity, unfolded-protein response, and activating transcription factor-6 Provides knowledge about biogenesis of insulin granules, role of SNARE proteins, SYNTAXIN, SNAP-25 and VAMP-2 in the intracellular trafficking and exocytosis of insulin granules Important component of book is the description about models of capillary blood flow in pancreatic islets, triggering pathway, amplifying pathway, role of nutrients, hormones especially Malonyl-CoA/Long chain-Acyl-CoA pathway, glucagon-like peptide-1, cholecystokinin hormone, ghrelin hormone, insulinotropic and insulinostatic effects of noradrenaline, Sirtuin 1, and mechanistic target of Rapamycin (mTOR) in insulin secretion Book proves knowledge about insulin mediated signaling pathways, role of glucose transporters, sodium-glucose linked transporters, and coverage of several metabolic and physiological effects of insulin including insulin mediated RANKL/RANK/OPG axis in osteoclastogenesis and bone resorption Additional component of the book is the chapter on the etiopathogenesis of insulin resistance covering wide range of topics including role of genetic polymorphisms (gene FABP-1, gene FABP-2, gene APOE, A-3826G polymorphism, A-1766G polymorphism, A-112C polymorphism of UCP-1 gene, G-866A polymorphism of UCP-2 gene, Polymorphisms of the APM1 gene and other genetic polymorphisms,) role of demographic factors, role of diseases (hemochromatosis, obesity, hypertension, NAFLD, lipotoxicity, Cushing syndromes and others), role of pro-inflammatory molecules, endoplasmic reticulum stress, and mitochondrial dysfunction in the pathogenesis of insulin resistance Special emphasis is given to explain the implication of advanced glycation end-products in the pathogenesis of insulin resistance covering topics like pathogenesis of AGEs, dietary AGEs, their effects on the pancreas, liver, adipose tissues, relation of AGEs-CD36-insulin resistance, and special coverage of psychological stress-insulin resistance-diabetes mellitus pathology Describes insulin resistance syndrome encompassing details regarding its prevalence and components Book blends both theoretical and clinical knowledge related to insulin and insulin resistance, and insulin resistance syndrome in a single volume eliminating searches through hundreds of journal articles Present book shall certainly serve as "ONE STOP SHOP" on the insulin, insulin resistance, and insulin resistance syndrome for the benefit of students, research scholars, academicians, and clinicians

This volume reprints eight of Anil Gupta's essays, some with additional material. The essays bring a refreshing new perspective to central issues in philosophical logic, philosophy of language, and epistemology. Gupta argues that logical interdependence is legitimate, and that it provides a key to understanding a variety of topics of interest to philosophers--including truth, rationality, and experience. The essays are highly accessible and provide a good introduction to ideas Gupta has been developing over the last three decades.

Anil Gupta asks one of the key questions in philosophy: what is the contribution of experience of knowledge? Gupta develops an account of experience that allows it to inform knowledge while respecting two constraints - the contribution of experience to knowledge must be both rational and substantial. He says that these constraints cannot be met if we make the assumption that experience only aquaints us with partial truth about the world. Instead he uses tools from philosophical logic, specifically the logic of interdependent concepts, to show that a natural account of experience is available using the interdependence of views and perceptual judgements. In essence he argues for a reformed empiricism that embraces experience as conditional.

This book offers a novel account of the relationship of experience to knowledge. The account builds on the intuitive idea that our ordinary perceptual judgments are not autonomous, that an interdependence obtains between our view of the world and our perceptual judgments. Anil Gupta shows in this important study that this interdependence is the key to a satisfactory account of experience. He uses tools from logic and the philosophy of language to argue that his account of experience makes available an attractive and feasible empiricism.

Anil Gupta here offers a systematic account of the concept of truth, with a particular focus on the role this concept plays in metaphysics. He examines functions the concept serves in everyday thinking and mounts, on their basis, an argument for a particular logic of truth. This logic enables, he argues, a new and powerful critique of deflationism--of the idea that the concept of truth is fit to serve only a logical role. The logic shows that deflationist claims about the contents of truth-attributions have only limited validity, and consequently, the accounts deflationists provide of truth are untenable. His book goes on to offer novel accounts of "appearance" and "phenomenon" and uses them, in conjunction with the newly improved understanding of the concept of truth, to clarify the metaphysical quest to understand reality. Gupta argues that the metaphysical inquiry into the nature of reality can equally well be described as an inquiry into the nature of truth.It is a distinctive merit of his book that Gupta brings together three streams of thinking about truth, streams that often run parallel to one another: the logical, the linguistic, and the metaphysical streams. He shows that ideas in the linguistic stream help overcome impasse in the logic of truth, and gains made in the latter help overcome stubborn misconceptions about the meaning and function of "'true". These gains, in turn, help correct metaphysical claims about the nature of truth, and indeed they help illuminate the metaphysical enterprise itself.

Ingestion of food is a physiological process among heterotrophic organisms to obtain nutrients for survival. The consumption of soil, clay and chalk by humans is labeled as geophagia. Ancient resources and modern references deliver valuable information concerning geophagia and pica in humans. This book takes a consistent, interdisciplinary approach for reviewing this aberrant behavior, crafting its etiology, charting its health effects and identifying the universal traits among the affected population. It puts forward a brief conceptual framework to achieve universality in its definition, history, epidemiology and multiple hypotheses thus help in adopting measures to control this habit.Key Features: 1. Systematic and meticulous flow of information on geophagia. 2. Guides general practioners, physicians, pediatricians to curb this practice in their patients. 3. A unique and concise treatise covering descriptive and research based work over a crucial health issue of worldwide prevalence.

Biochemical parameters represent better, precise, and objective tools toward the assessment of the nutritional status of children in comparison to anthropometric, clinical, and dietary methods. They constitute laboratory tests to estimate the concentration of circulating nutrients in body fluids. Biochemical parameters are suggestive of acute or subclinical conditions when other methods of nutritional assessment fail to interpret the condition. These parameters exhibit substantial variability in their reproducibility. Moreover, these parameters are novel tools in the hands of clinicians for screening of the nutritional status of children.Key Features Covers the latest biochemical parameters for nutritional assessment Updated content is useful for clinicians, nutritionists, and general practitioners A unique and concise treatise covering descriptive and research-based work on a crucial health issue of worldwide prevalenceAbout the AuthorAnil Gupta, PhD, is the Dean of Research at Desh Bhagat University and Professor and Head, Department of Physiology and Biochemistry at Desh Bhagat Dental College and Hospital, Mandi Gobindgarh, Punjab, India.

Biochemical parameters represent better, precise, and objective tools toward the assessment of the nutritional status of children in comparison to anthropometric, clinical, and dietary methods. They constitute laboratory tests to estimate the concentration of circulating nutrients in body fluids. Biochemical parameters are suggestive of acute or subclinical conditions when other methods of nutritional assessment fail to interpret the condition. These parameters exhibit substantial variability in their reproducibility. Moreover, these parameters are novel tools in the hands of clinicians for screening of the nutritional status of children.Key Features Covers the latest biochemical parameters for nutritional assessment Updated content is useful for clinicians, nutritionists, and general practitioners A unique and concise treatise covering descriptive and research-based work on a crucial health issue of worldwide prevalenceAbout the AuthorAnil Gupta, PhD, is the Dean of Research at Desh Bhagat University and Professor and Head, Department of Physiology and Biochemistry at Desh Bhagat Dental College and Hospital, Mandi Gobindgarh, Punjab, India.

This volume serves to present to interested readers recent developments in microsimulation and public policy. It strings together: selected papers presented at the International Microsimulation Conference on Population Ageing and Health: Modelling Our Future held in Canberra, Australia in December 2003; and recent thinking in the field of microsimulation as reflected in special contributions by some of the leading experts in the field; description of 20 key models relating to fiscal and health human resource issues concerning sustainability of health systems around the globe. The focus of the conference was on practical uses of microsimulation in government policy although theoretical underpinnings also received considerable attention. The volume covers a diversity of subjects: health status; pharmacare and health expenditure issues; financing, caring and health delivery; health human resources; and data challenges. To provide an insight into actual models used around the world, the book also has a section devoted to the challenges associated with building of microsimulation models and their current use in the formulation of public policy. The book presents some innovative analysis on public policy issues contained in some of the conference papers along with the methodological advancements made in the microsimulation field. It contains invaluable information that aims to help shape the current and future public policy debates in this area. The authors are established leaders in the field, and it is international in scope.

A distinguished philosopher offers a novel account of experience and reason, and develops our understanding of conscious experience and its relationship to thought: a new reformed empiricism.The role of experience in cognition is a central and ancient philosophical concern. How, theorists ask, can our private experiences guide us to knowledge of a mind-independent reality? Exploring topics in logic, philosophy of mind, and epistemology, Conscious Experience proposes a new answer to this age-old question, explaining how conscious experience contributes to the rationality and content of empirical beliefs.According to Anil Gupta, this contribution cannot be determined independently of an agent’s conceptual scheme and prior beliefs, but that doesn’t mean it is entirely mind-dependent. While the rational contribution of an experience is not propositional—it does not, for example, provide direct knowledge of the world—it does authorize certain transitions from prior views to new views. In short, the rational contribution of an experience yields a rule for revising views. Gupta shows that this account provides theoretical freedom: it allows the observer to radically reconceive the world in light of empirical findings. Simultaneously, it grants empirical reason significant power to constrain, forcing particular conceptions of self and world on the rational inquirer. These seemingly contrary virtues are reconciled through novel treatments of presentation, appearances, and ostensive definitions.Collectively, Gupta’s arguments support an original theory: reformed empiricism. He abandons the idea that experience is a source of knowledge and justification. He also abandons the idea that concepts are derived from experience. But reformed empiricism preserves empiricism’s central insight: experience is the supreme epistemic authority. In the resolution of factual disagreements, experience trumps all.

The issues associated with population ageing are already assuming prominence in most OECD countries. Many governments are extremely concerned about the likely impact of population ageing upon future government outlays and economic growth. In Australia, for example, there have already been two major government reports that have attempted to quantify the likely implications for government spending of population ageing. These reports have concluded that there will either have to be cuts in current government programs, increases in taxes or some combination of these. The ageing population will also require more health human resources (doctors, nurses, pharmacists etc.), in an environment where the existing workforce itself is ageing. Economic growth is forecast to slow significantly in future decades due to population ageing, reducing governments ability to rely on a rapidly growing taxpaying labour force to finance the expected shortfalls. Against this backdrop, volumes 15 and 16 of the International Symposia in Economic Theory and Econometrics Series provide very timely and relevant research for policy makers and researchers across the world. The modelling approaches and research described in the volumes are at the international leading edge, providing insights into how different countries are facing the challenges associated with population ageing. Many countries have developed microsimulation and other models to help them evaluate the impacts of population ageing and of public policy change. Volume 15 concentrates upon the impacts of population ageing upon social security and taxation. For example, the chapters examine likely future pension outlays under current and possible alternative schemes; estimate the likely wealth of future retirees; forecast tax revenues out to 2026 and look at the impact of population ageing upon housing prices and tourism. This volume contains invaluable information that aims to help shape the current and future public policy debates in this area. The authors are established leaders in the field. It includes international in Scope.

Ingestion of food is a physiological process among heterotrophic organisms to obtain nutrients for survival. The consumption of soil, clay and chalk by humans is labeled as geophagia. Ancient resources and modern references deliver valuable information concerning geophagia and pica in humans. This book takes a consistent, interdisciplinary approach for reviewing this aberrant behavior, crafting its etiology, charting its health effects and identifying the universal traits among the affected population. It puts forward a brief conceptual framework to achieve universality in its definition, history, epidemiology and multiple hypotheses thus help in adopting measures to control this habit.Key Features:1. Systematic and meticulous flow of information on geophagia.2. Guides general practioners, physicians, pediatricians to curb this practice in their patients. 3. A unique and concise treatise covering descriptive and research based work over a crucial health issue of worldwide prevalence.

Global warming and population growth have resulted in an increase in the intensity of natural and anthropogenic stressors. Investigating the complex nature of environmental problems requires the integration of different environmental processes across major components of the environment, including water, climate, ecology, air, and land. Cumulative effects assessment (CEA) not only includes analyzing and modeling environmental changes, but also supports planning alternatives that promote environmental monitoring and management. Disjointed and narrowly focused environmental management approaches have proved dissatisfactory. The adoption of integrated modelling approaches has sparked interests in the development of frameworks which may be used to investigate the processes of individual environmental component and the ways they interact with each other. Integrated modelling systems and frameworks are often the only way to take into account the important environmental processes and interactions, relevant spatial and temporal scales, and feedback mechanisms of complex systems for CEA. This book examines the ways in which interactions and relationships between environmental components are understood, paying special attention to climate, land, water quantity and quality, and both anthropogenic and natural stressors. It reviews modelling approaches for each component and reviews existing integrated modelling systems for CEA. Finally, it proposes an integrated modelling framework and provides perspectives on future research avenues for cumulative effects assessment.

Global warming and population growth have resulted in an increase in the intensity of natural and anthropogenic stressors. Investigating the complex nature of environmental problems requires the integration of different environmental processes across major components of the environment, including water, climate, ecology, air, and land. Cumulative effects assessment (CEA) not only includes analyzing and modeling environmental changes, but also supports planning alternatives that promote environmental monitoring and management.Disjointed and narrowly focused environmental management approaches have proved dissatisfactory. The adoption of integrated modelling approaches has sparked interests in the development of frameworks which may be used to investigate the processes of individual environmental component and the ways they interact with each other. Integrated modelling systems and frameworks are often the only way to take into account the important environmental processes and interactions, relevant spatial and temporal scales, and feedback mechanisms of complex systems for CEA.This book examines the ways in which interactions and relationships between environmental components are understood, paying special attention to climate, land, water quantity and quality, and both anthropogenic and natural stressors. It reviews modelling approaches for each component and reviews existing integrated modelling systems for CEA. Finally, it proposes an integrated modelling framework and provides perspectives on future research avenues for cumulative effects assessment.

When the seemingly perfect Tartuffe ingratiates himself with the wealthy Orgon and his mother Madame Pernelle, he is soon welcomed into their home and into their lives. His combination of charm, respectability and religious authority proves so irresistible that he is eventually promised the hand of Orgon's daughter in marriage. But the rest of Orgon's family have grave doubts - is there more to Tartuffe than meets the eye? When the threat of eviction for the family and imprisonment for Orgon become apparent, is it all too late to find out?This hilarious and irreverent whirlwind of lies, religious hypocrisy and family feuds features one of theatre's most perfect comedy creations, the beguiling Tartuffe.