Anil K. Sharma – författare

This new volume, Nanocarriers for Brain Targeting: Principles and Applications, covers recent research on brain physiology and the development of drug delivery systems. It explores a diverse variety of strategies that can be employed to achieve drug targeting to the brain. The nanocarriers that are discussed include nanoparticles, vesicular carriers, carriers having carbon as a core constituent, dispersed systems, and more.

The inherent anatomy and physiology of the brain renders it different from other organs. The past few decades have witnessed significant research on brain ailments in response to a majority of hospitalizations that occur due to age-related central nervous system disorders. The prevalence of diverse diseases such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, multiple sclerosis, HIV-dementia, etc., affect about 1.5 billion people globally, which is further anticipated to reach 1.9 billion by the year 2020. Nanocarriers for drug delivery to the brain are seen as one of the answers to this growing problem.

This new volume, Nanocarriers for Brain Targeting: Principles and Applications, covers recent research on brain physiology and the development of drug delivery systems. It explores a diverse variety of strategies that can be employed to achieve drug targeting to the brain. The nanocarriers that are discussed include nanoparticles, vesicular carriers, carriers having carbon as a core constituent, dispersed systems, and more.

The inherent anatomy and physiology of the brain renders it different from other organs. The past few decades have witnessed significant research on brain ailments in response to a majority of hospitalizations that occur due to age-related central nervous system disorders. The prevalence of diverse diseases such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, multiple sclerosis, HIV-dementia, etc., affect about 1.5 billion people globally, which is further anticipated to reach 1.9 billion by the year 2020. Nanocarriers for drug delivery to the brain are seen as one of the answers to this growing problem.

This new volume on applications and advances in tissue engineering presents significant, state-of-the-art developments in this exciting area of research. It highlights some of the most important applied research on the applications of tissue engineering along with its different components, specifically different types of biomaterials. It looks at the various issues involved in tissue engineering, including smart polymeric biomaterials, gene therapy, tissue engineering in reconstruction and regeneration of visceral organs, skin tissue engineering, bone and muscle regeneration, and applications in tropical medicines. Covering a wide range of issues in tissue engineering, the volume

Providing an abundance of advanced research and information, Tissue Engineering: Applications and Advancements will be a valuable resource for medical researchers, pharmaceutical manufacturers, healthcare personnel, and academicians.

This new volume on applications and advances in tissue engineering presents significant, state-of-the-art developments in this exciting area of research. It highlights some of the most important applied research on the applications of tissue engineering along with its different components, specifically different types of biomaterials. It looks at the various issues involved in tissue engineering, including smart polymeric biomaterials, gene therapy, tissue engineering in reconstruction and regeneration of visceral organs, skin tissue engineering, bone and muscle regeneration, and applications in tropical medicines. Covering a wide range of issues in tissue engineering, the volume

Providing an abundance of advanced research and information, Tissue Engineering: Applications and Advancements will be a valuable resource for medical researchers, pharmaceutical manufacturers, healthcare personnel, and academicians.

Topical and transdermal drug delivery systems (TDDs) have several advantages over traditional drug delivery methods, as they can be less invasive, more sanitary, more cost-effective, and may result in better patient compliance. TDDs play a significant role in therapeutics with a variety of preparations and approaches designed by expert formulation scientists. This volume integrates a wide variety of case studies, research, and theories to reveal their diversity and capture the novel approaches of transdermal and topical drug delivery employed by developers and content experts in the field. It provides an abundance of important information and state-of-the-art research on topical and transdermal drug delivery systems and addresses the basics of drug delivery systems, strategies to enhance permeation across membranes, and formulation and evaluation of diverse dosage forms.

The volume presents an evaluation of the pros and cons of conventional drug delivery systems against TDDs and discusses the nuances of micro- and nano-systems in TDDs. The extraordinary packages of nano systems (vesicular systems, polymeric nanoparticles, nanoemulsion and dendrimers) are broadly discussed, and their applications are reviewed through a transdermal route.

The book looks at TDDs and the main nanoparticles used in skin diseases and lesions of the aging, such as psoriasis, vitiligo, cancer, lesions of the aging and others. Chapters also discuss polymeric micelles in topical and transdermal delivery; microneedles; emulsion, nanoemulsion and microemulsion; TDDs in pulmonary drug delivery systems; nanoencapsulated nasal drug delivery systems; skin sensitivity and irritation testing for transposing transdermal drug delivery systems; and regulatory aspects of drug development for dermal products.

Topical and Transdermal Drug Delivery Systems: Applications and Prospects will be a valuable resource for pharmaceutical scientists and researchers, industry professionals, and academicians and students of the pharmaceutical and biomedical sciences.

Topical and transdermal drug delivery systems (TDDs) have several advantages over traditional drug delivery methods, as they can be less invasive, more sanitary, more cost-effective, and may result in better patient compliance. TDDs play a significant role in therapeutics with a variety of preparations and approaches designed by expert formulation scientists. This volume integrates a wide variety of case studies, research, and theories to reveal their diversity and capture the novel approaches of transdermal and topical drug delivery employed by developers and content experts in the field. It provides an abundance of important information and state-of-the-art research on topical and transdermal drug delivery systems and addresses the basics of drug delivery systems, strategies to enhance permeation across membranes, and formulation and evaluation of diverse dosage forms.

The volume presents an evaluation of the pros and cons of conventional drug delivery systems against TDDs and discusses the nuances of micro- and nano-systems in TDDs. The extraordinary packages of nano systems (vesicular systems, polymeric nanoparticles, nanoemulsion and dendrimers) are broadly discussed, and their applications are reviewed through a transdermal route.

The book looks at TDDs and the main nanoparticles used in skin diseases and lesions of the aging, such as psoriasis, vitiligo, cancer, lesions of the aging and others. Chapters also discuss polymeric micelles in topical and transdermal delivery; microneedles; emulsion, nanoemulsion and microemulsion; TDDs in pulmonary drug delivery systems; nanoencapsulated nasal drug delivery systems; skin sensitivity and irritation testing for transposing transdermal drug delivery systems; and regulatory aspects of drug development for dermal products.

Topical and Transdermal Drug Delivery Systems: Applications and Prospects will be a valuable resource for pharmaceutical scientists and researchers, industry professionals, and academicians and students of the pharmaceutical and biomedical sciences.

Addressing the increasing popularity of nutraceuticals, dietary supplements, and functional foods, this comprehensive and timely book presents an abundance of information on herbal products and their applications. The chapter authors—highly skilled, experienced, and renowned scientists and researchers from around the globe—offer up-to-date knowledge on the uses of herbal products in health management, in cancer treatment, in mental health therapy, and more.

Nutraceuticals and Dietary Supplements: Advances and Applications begins with an introduction, the nomenclature, and characteristics of nutraceuticals and goes on to discuss in-depth applications for specific health issues, including cancer, diabetes, Alzheimer’s disease, alcoholism, and more. It also looks at the pros and cons as well as the analytical techniques used for the production of nutraceuticals. Chapters cover market size, regulatory perspectives, manufacturing, and in silico drug design. The book incorporates a wide diversity of case studies, research, and theories pertaining to natural products employed by developers and content experts in the field.

Addressing the increasing popularity of nutraceuticals, dietary supplements, and functional foods, this comprehensive and timely book presents an abundance of information on herbal products and their applications. The chapter authors—highly skilled, experienced, and renowned scientists and researchers from around the globe—offer up-to-date knowledge on the uses of herbal products in health management, in cancer treatment, in mental health therapy, and more.

Nutraceuticals and Dietary Supplements: Advances and Applications begins with an introduction, the nomenclature, and characteristics of nutraceuticals and goes on to discuss in-depth applications for specific health issues, including cancer, diabetes, Alzheimer’s disease, alcoholism, and more. It also looks at the pros and cons as well as the analytical techniques used for the production of nutraceuticals. Chapters cover market size, regulatory perspectives, manufacturing, and in silico drug design. The book incorporates a wide diversity of case studies, research, and theories pertaining to natural products employed by developers and content experts in the field.

This new volume, Herbal Product Development: Formulation and Applications, addresses some of the challenges that hinder the path of successful natural products from laboratory to market. Highly skilled, experienced, and renowned scientists and researchers from around the globe offer up-to-date information that describes characteristics of herbs and herbal products, applications, evaluation techniques, and more. There is also a section dedicated to alternative medicinal strategies for the treatment and cure of diverse diseases. Also considered, of course, is the efficacy and safety of herbal products, which are of major concern.

This valuable volume will be an important addition to the library of those involved in herbal product development and testing, including researchers, scientists, academicians, industry professionals, and students in this area.

This new volume, Herbal Product Development: Formulation and Applications, addresses some of the challenges that hinder the path of successful natural products from laboratory to market. Highly skilled, experienced, and renowned scientists and researchers from around the globe offer up-to-date information that describes characteristics of herbs and herbal products, applications, evaluation techniques, and more. There is also a section dedicated to alternative medicinal strategies for the treatment and cure of diverse diseases. Also considered, of course, is the efficacy and safety of herbal products, which are of major concern.

This valuable volume will be an important addition to the library of those involved in herbal product development and testing, including researchers, scientists, academicians, industry professionals, and students in this area.

This new volume, Promising Drug Molecules of Natural Origin, explores potential beneficial drug substances derived from nature. It presents the general principles, characteristics, evaluation techniques, and applications involved in drug molecules from natural sources, such as plants and marine life. With chapters from renowned experts from around the world, the chapters in this volume address the challenges of standardization of herbal medicines, methods of characterization of natural medicines and phyto-constituents, and quality control methods for herbal medicines. Several chapters in the book focus on the evolution of phyto-constituents in cancer therapeutics, while others deal with applications for other diseases, such as diabetes and neuroinflammatory disorders. The volume also specifically reviews heterocyclic drugs from plants.

This volume will be a valuable resource for faculty and advanced students in pharmaceutics as well as researchers, scientists, and industry professionals in medicine and drug development.

This new volume, Promising Drug Molecules of Natural Origin, explores potential beneficial drug substances derived from nature. It presents the general principles, characteristics, evaluation techniques, and applications involved in drug molecules from natural sources, such as plants and marine life. With chapters from renowned experts from around the world, the chapters in this volume address the challenges of standardization of herbal medicines, methods of characterization of natural medicines and phyto-constituents, and quality control methods for herbal medicines. Several chapters in the book focus on the evolution of phyto-constituents in cancer therapeutics, while others deal with applications for other diseases, such as diabetes and neuroinflammatory disorders. The volume also specifically reviews heterocyclic drugs from plants.

This volume will be a valuable resource for faculty and advanced students in pharmaceutics as well as researchers, scientists, and industry professionals in medicine and drug development.

Formulations, Regulations, and Challenges of Nutraceuticals focuses on various novel micro- and nanocarriers being employed in the formulation and delivery of nutraceutical ingredients to increase their efficacy, bioavailability, safety, and stability. It also highlights the current challenges and future strategies for the development of novel nutraceuticals and functional foods with enhanced health benefits. The focus is on the formulations and regulations.

As compared to traditional drugs, there are no minimal regulations on nutraceutical products, which make them more market friendly. Since nutraceutical ingredients have no defined regulations at global level, they are not considered as medicine or therapeutic agents. Some countries have devised their own guidelines for regulating the usage of nutraceuticals, either as pharmaceutical ingredients or as food supplements. This volume addresses the need for common regulatory guidelines with important research on the production of stable and efficient nutraceutical formulations. The numerous regulatory frameworks being employed in Asia and European regulatory agencies in commercialization of nutraceutical products produced by manufacturing companies are discussed.

Chapters examine the factors affecting the stability of nutraceuticals in food and gut environments by stressing the results generated from in vitro and in vivo studies and suggests good manufacturing practices to be followed for the development of nutraceuticals.

Formulations, Regulations, and Challenges of Nutraceuticals will be valuable for upper-level students, faculty, nutraceutical researchers and practitioners, regulatory agencies, and those involved in the production and development of nutraceutical products.

Formulations, Regulations, and Challenges of Nutraceuticals focuses on various novel micro- and nanocarriers being employed in the formulation and delivery of nutraceutical ingredients to increase their efficacy, bioavailability, safety, and stability. It also highlights the current challenges and future strategies for the development of novel nutraceuticals and functional foods with enhanced health benefits. The focus is on the formulations and regulations.

As compared to traditional drugs, there are no minimal regulations on nutraceutical products, which make them more market friendly. Since nutraceutical ingredients have no defined regulations at global level, they are not considered as medicine or therapeutic agents. Some countries have devised their own guidelines for regulating the usage of nutraceuticals, either as pharmaceutical ingredients or as food supplements. This volume addresses the need for common regulatory guidelines with important research on the production of stable and efficient nutraceutical formulations. The numerous regulatory frameworks being employed in Asia and European regulatory agencies in commercialization of nutraceutical products produced by manufacturing companies are discussed.

Chapters examine the factors affecting the stability of nutraceuticals in food and gut environments by stressing the results generated from in vitro and in vivo studies and suggests good manufacturing practices to be followed for the development of nutraceuticals.

Formulations, Regulations, and Challenges of Nutraceuticals will be valuable for upper-level students, faculty, nutraceutical researchers and practitioners, regulatory agencies, and those involved in the production and development of nutraceutical products.

Here is an informative volume on the importance of nutraceuticals and herbal remedies for bone health. It explains the probable mechanisms of nutraceuticals for the prevention, treatment, and management of bone-related diseases as well as their curable effects on bone injuries. The volume covers the progression and development of bones, which is a multifaceted process that requires an endless and ample supply of nutrients, such as calcium, phosphorus, potassium, protein, vitamin D, magnesium, and fluoride. The book delves into the beneficial effects of nutraceuticals on overall bone health and for the treatment of bone disorders such as osteoporosis, bone fractures, scoliosis and related complications, rheumatoid arthritis, Paget’s disease, bursitis, gout, and carpal tunnel syndrome. It also addresses the use of nutraceuticals for inflammatory deformities and rickets.

Here is an informative volume on the importance of nutraceuticals and herbal remedies for bone health. It explains the probable mechanisms of nutraceuticals for the prevention, treatment, and management of bone-related diseases as well as their curable effects on bone injuries. The volume covers the progression and development of bones, which is a multifaceted process that requires an endless and ample supply of nutrients, such as calcium, phosphorus, potassium, protein, vitamin D, magnesium, and fluoride. The book delves into the beneficial effects of nutraceuticals on overall bone health and for the treatment of bone disorders such as osteoporosis, bone fractures, scoliosis and related complications, rheumatoid arthritis, Paget’s disease, bursitis, gout, and carpal tunnel syndrome. It also addresses the use of nutraceuticals for inflammatory deformities and rickets.

This volume addresses efforts to overcome the shortcomings of conventional dosage forms by exploiting the principles of nanoscience to deliver drugs for medical treatment. Nanodispersions are an important aspect because they possess globules/particles in sizes usually below 1000 nm in which the drug is dispersed in a continuous medium employing surface-active agents as stabilizers. With chapters written by experienced scientists and researchers in the field, this volume provides an abundance of information on various aspects of nanodispersions for drug delivery. The book is divided into several sections: nanoemulsions, nanosuspensions, and diverse dispersed systems.

The chapters detail what nanodispersions have demonstrated in the past and what they are expoected to continue to do in the future as the technology further evolves.

Key features:

• Provides an overview of nanoemulsions for drug delivery

• Introduces the general principles, classification, and methods of preparation of nanoemulsion-based drug delivery systems

• Presents information relevant to specific routes of applications of nanoemulsions

• Looks at the various aspects of nanosuspensions, including their formulation components, preparation methods, unique features, methods of characterization, and applications in various routes of administration

• Explores nanomicellar approaches for drug delivery

• Discusses the preparation, applications, and clinical considerations of nanogels for drug delivery

This volume addresses efforts to overcome the shortcomings of conventional dosage forms by exploiting the principles of nanoscience to deliver drugs for medical treatment. Nanodispersions are an important aspect because they possess globules/particles in sizes usually below 1000 nm in which the drug is dispersed in a continuous medium employing surface-active agents as stabilizers. With chapters written by experienced scientists and researchers in the field, this volume provides an abundance of information on various aspects of nanodispersions for drug delivery. The book is divided into several sections: nanoemulsions, nanosuspensions, and diverse dispersed systems.

The chapters detail what nanodispersions have demonstrated in the past and what they are expoected to continue to do in the future as the technology further evolves.

Key features:

• Provides an overview of nanoemulsions for drug delivery

• Introduces the general principles, classification, and methods of preparation of nanoemulsion-based drug delivery systems

• Presents information relevant to specific routes of applications of nanoemulsions

• Looks at the various aspects of nanosuspensions, including their formulation components, preparation methods, unique features, methods of characterization, and applications in various routes of administration

• Explores nanomicellar approaches for drug delivery

• Discusses the preparation, applications, and clinical considerations of nanogels for drug delivery

Focusing on nanoparticulate nanocarriers and recent advances in the field of drug delivery, the volume begins with chapters that provide an informative introduction to polymeric nanoparticles—their general physicochemical features and characteristics, their applications in drug delivery systems, and the challenges involved. Specific applications are discussed, with attention paid to treatment of particular diseases and disorders and the targeting of specific organs.

Part 2 looks at more specific applications and techniques of nanoparticulate nanocarriers for drug delivery, such as the use of magnetic nanoparticles, gold nanoparticles in therapeutics, and superparamagnetic iron oxide nanoparticles (SPIONs) for the treatment of cancer. Part 3 discusses lipid-based nanoparticulates for various applications, including skin care. The last section of the book explores some of the newer nanoarchitectures, including dendrimers in gene delivery and carbon nanotubes for drug delivery.

Together, the insightful research presented here provides valuable information for those involved in this area, including scientists and researchers and faculty and upper-level students, as well as for industry professionals.

Focusing on nanoparticulate nanocarriers and recent advances in the field of drug delivery, the volume begins with chapters that provide an informative introduction to polymeric nanoparticles—their general physicochemical features and characteristics, their applications in drug delivery systems, and the challenges involved. Specific applications are discussed, with attention paid to treatment of particular diseases and disorders and the targeting of specific organs.

Part 2 looks at more specific applications and techniques of nanoparticulate nanocarriers for drug delivery, such as the use of magnetic nanoparticles, gold nanoparticles in therapeutics, and superparamagnetic iron oxide nanoparticles (SPIONs) for the treatment of cancer. Part 3 discusses lipid-based nanoparticulates for various applications, including skin care. The last section of the book explores some of the newer nanoarchitectures, including dendrimers in gene delivery and carbon nanotubes for drug delivery.

Together, the insightful research presented here provides valuable information for those involved in this area, including scientists and researchers and faculty and upper-level students, as well as for industry professionals.

This new volume presents a plethora of new research on the use of nanoconjugate nanocarriers in drug delivery. Nanotechnology as drug carriers has been observed to increase the level of sophistication through a variety of ways. It helps to alleviate some of the pitfalls of conventional dosage forms, such as few pitfalls such as non-specific drug delivery, dose dumping, poor patient compliance, toxicities linked with higher doses, etc.

With chapters from highly skilled, experienced, and renowned scientists and researchers, Nanoconjugate Nanocarriers for Drug Delivery is divided into four sections, providing an introduction to nanocarriers for drug delivery, physicochemical features of nanocarriers, and specific applications dealing with drug delivery in particular. The materials used as well as formulation and characterization have been discussed in detail. The nanocarriers covered in the book include nanoparticles, vesicular carriers, carriers having carbon as the core constituent, dispersed systems, etc. The book also delves into the interaction and associations between drug delivery research and its therapeutic applications in practice.

The book integrates a wide variety of case studies, research, and theories in an attempt to reveal the diversity and capture the novel approaches of nanoconjugate nanocarriers for drug delivery employed by developers and content experts in the field.

This timely publication will be an essential reference and current awareness source, building on the available literature in the field of pharmacy and biomedical science, while also providing ideas for further research opportunities in this dynamic field.

This new volume presents a plethora of new research on the use of nanoconjugate nanocarriers in drug delivery. Nanotechnology as drug carriers has been observed to increase the level of sophistication through a variety of ways. It helps to alleviate some of the pitfalls of conventional dosage forms, such as few pitfalls such as non-specific drug delivery, dose dumping, poor patient compliance, toxicities linked with higher doses, etc.

With chapters from highly skilled, experienced, and renowned scientists and researchers, Nanoconjugate Nanocarriers for Drug Delivery is divided into four sections, providing an introduction to nanocarriers for drug delivery, physicochemical features of nanocarriers, and specific applications dealing with drug delivery in particular. The materials used as well as formulation and characterization have been discussed in detail. The nanocarriers covered in the book include nanoparticles, vesicular carriers, carriers having carbon as the core constituent, dispersed systems, etc. The book also delves into the interaction and associations between drug delivery research and its therapeutic applications in practice.

The book integrates a wide variety of case studies, research, and theories in an attempt to reveal the diversity and capture the novel approaches of nanoconjugate nanocarriers for drug delivery employed by developers and content experts in the field.

This timely publication will be an essential reference and current awareness source, building on the available literature in the field of pharmacy and biomedical science, while also providing ideas for further research opportunities in this dynamic field.

With chapters from highly skilled, experienced, and renowned scientists and researchers from around the globe, Dendrimers for Drug Delivery provides an abundance of information on dendrimers and their applications in the field of drug delivery.

The volume begins with an introduction to dendrimers, summarizing dendrimer applications and the striking features of dendrimers. It goes on to present the details of usual properties, structure, classification, and methods of synthesis, with relevant examples. The toxicity of dendrimers is also discussed. The chapter authors provide an exhaustive amount of information about dendrimers and their biomedical applications, including biocompatibility and toxicity aspects, a very useful feature.

This informative volume will be valuable resource that will help readers to create products derived from dendrimers and navigate through the regulatory, manufacturing, and quality control hurdles. It will be an important resource for researchers, scientists, upper-level students, and industry professionals.

With chapters from highly skilled, experienced, and renowned scientists and researchers from around the globe, Dendrimers for Drug Delivery provides an abundance of information on dendrimers and their applications in the field of drug delivery.

The volume begins with an introduction to dendrimers, summarizing dendrimer applications and the striking features of dendrimers. It goes on to present the details of usual properties, structure, classification, and methods of synthesis, with relevant examples. The toxicity of dendrimers is also discussed. The chapter authors provide an exhaustive amount of information about dendrimers and their biomedical applications, including biocompatibility and toxicity aspects, a very useful feature.

This informative volume will be valuable resource that will help readers to create products derived from dendrimers and navigate through the regulatory, manufacturing, and quality control hurdles. It will be an important resource for researchers, scientists, upper-level students, and industry professionals.

This new volume focuses on the ever-growing and ever-sophisticated use of nanobiomaterials in drug delivery. There have been significant developments in the delivery of the active pharmaceutical ingredients to target sites, thereby sparing the normal functioning biological systems from damage, and this volume highlights some of the most important developments in the field.

The book first provides an overview of nanobiomaterials and then goes on to report on new developments in drug delivery and nanotechnology, nanobiomaterials as carriers in cancer therapy, and the diverse uses of nanobiomaterials.

Broken into sections, the chapters cover:

This volume will be a valuable resource on drug delivery for pharmaceutical manufacturers, healthcare personnel, and researchers.