Antonio Russo – författare

Liquid Biopsy: New Challenges in the era of Immunotherapy and Precision Oncology aims to describe links between cancer, precision oncology, and liquid biopsy, focusing on their participation to immunotherapy management. The book provides updated information on the main applications of liquid biopsy and immunotherapy as well as interesting aspects useful for planning basic and translational research activities. It helps readers understand the central aspects of precision medicine in oncology, including the use of new generation technologies for translational and diagnostic settings and the main clinical trials in this area that may be useful during their research.The book is a valuable source for cancer researchers, oncologists and other members of the medical and biomedical field who are interested in learning more about recent developments in liquid biopsy and its relationship with precision medicine and immunotherapy. Presents a "highlights section� in every chapter to help readers summarize the main aspects discussed Encompasses case reports to guide the reader on applying what they read in their clinical practice Includes several tables and figures specially created for the book to illustrate the meaning of what is expressed in the text

Student communities are without doubt a strategic resource for urban development and students are the citizens and the high-skilled working class of tomorrow. They are seen as an 'invisible population' with little say in local policy and decision-making. Co-operation between educational institutions and city planners is often missing and cities tend to neglect the universities' foreign relations. This volume argues that the importance of human capital in the competitiveness of cities demands pro-active, integral city policies targeting this community. Bringing together nine case studies of European cities (Rotterdam, Utrecht, Eindhoven, Munich, Lyon, Lille, Venice, Birmingham and Helsinki), it puts forward a comprehensive strategic plan of action, aiming at the integration of student communities in urban development. The book analyses the essential characteristics of the relationship between students and their host communities, as well as the role of higher education institutions and other actors in building the 'student friendly' city.

Student communities are without doubt a strategic resource for urban development and students are the citizens and the high-skilled working class of tomorrow. They are seen as an 'invisible population' with little say in local policy and decision-making. Co-operation between educational institutions and city planners is often missing and cities tend to neglect the universities' foreign relations. This volume argues that the importance of human capital in the competitiveness of cities demands pro-active, integral city policies targeting this community. Bringing together nine case studies of European cities (Rotterdam, Utrecht, Eindhoven, Munich, Lyon, Lille, Venice, Birmingham and Helsinki), it puts forward a comprehensive strategic plan of action, aiming at the integration of student communities in urban development. The book analyses the essential characteristics of the relationship between students and their host communities, as well as the role of higher education institutions and other actors in building the 'student friendly' city.

Targeted Therapies for Solid Tumors

This volume provides readers a comprehensive and state-of-the-art overview about the range of applications of targeted therapies for solid tumors. The sections of the book have been structured to review the oncogene addicted tumors, the pharmacology and clinical development of new molecularly targeted agents, the use of biomarkers as prognostic, predictive and surrogate endpoints, and the evaluation of tumor response and specific malignancies treated with targeted agents. The book also covers some of the newest developments in cancer therapy that are not adequately covered by any current available literature.Written by recognized experts in the field, Targeted Therapies for Solid Tumors: A Handbook for Moving Toward New Frontiers in Cancer Treatment provides a unique and valuable resource in the field of molecular oncology, both for those currently in training, and for those already in clinical or research practice.

Gene expression studies have revealed diagnostic profiles and upregulation of specific pathways in many solid tumors. The explosion of new information in gene expression profiling could potentially lead to the development of tailored treatments in many solid tumors. In addition many studies are ongoing to validate these signatures also in predicting response to hormonal, chemotherapeutic and targeted agents in breast cancer as well as in other tumors. Diagnostic, Prognostic and Therapeutic Value of Gene Signatures provides readers a useful and comprehensive resource about the range of applications of microarray technology in oncological diseases. Topics covered include gene signatures and soft tissue sarcomas, prognostic relevance of breast cancer signatures, gene expression profiling of colorectal cancer and liver metastasis, gene signatures in GISTs, CNVs and gene expression profiles in pancreatic cancer, and gene signatures in head/neck, lung and gastric tumors. Diagnostic, Prognostic and Therapeutic Value of Gene Signatures will be of great value to residents and fellows, physicians, pathologists and  medical oncologists.

Gene expression studies have revealed diagnostic profiles and upregulation of specific pathways in many solid tumors. The explosion of new information in gene expression profiling could potentially lead to the development of tailored treatments in many solid tumors. In addition many studies are ongoing to validate these signatures also in predicting response to hormonal, chemotherapeutic and targeted agents in breast cancer as well as in other tumors. Diagnostic, Prognostic and Therapeutic Value of Gene Signatures provides readers a useful and comprehensive resource about the range of applications of microarray technology in oncological diseases. Topics covered include gene signatures and soft tissue sarcomas, prognostic relevance of breast cancer signatures, gene expression profiling of colorectal cancer and liver metastasis, gene signatures in GISTs, CNVs and gene expression profiles in pancreatic cancer, and gene signatures in head/neck, lung and gastric tumors. Diagnostic, Prognostic and Therapeutic Value of Gene Signatures will be of great value to residents and fellows, physicians, pathologists and  medical oncologists.

This proposed text is designed to provide a useful and comprehensive resource and state-of-the-art overview to readers about vascular damage  potentially induced by antineoplastic drugs. Thanks to more and more effective antineoplastic treatments the survival of cancer patients is enormously increasing, but at the same time it is increasing the burden of related cardiovascular complications that affect morbidity and mortality. On this basis a new branch of cardiology has been developed, that is Cardio-Oncology. The aim is to prevent cardiovascular complications related to cancer therapy and to facilitate and avoid interruption of antineoplastic drugs due to the occurrence of cardiovascular damage. An increasing attention has been given to cardiac damage, while, until today, vascular complications have been poorly evaluated. The aim of this book is to focus on vascular complications related to cancer treatment, to guide the clinician at facing,during his every day practice, cardiovascular toxicity in cancer and hematologic patients. The proposed sections of the book have been structured to review the molecular mechanisms underlying vascular damage induced by new and old treatments, to describe the various manifestations of vascular disease that may range from artery to venous disease (including coronary artery disease, peripheral arterial disease, venous thromboembolism and pulmonary hypertension), and to provide advice to monitor patients undergoing onco-hematologic treatments in order to prevent and eventually manage vascular damage.This book will address resident and fellow physicians, medical oncologists, cardiologists, general practitioners and all those who take care of these patients.All invited authors will be recognized experts in their field, and leading international researchers on these topics. The editor has worked with these expert colleagues on a variety of other projects.The authors will provide their manuscript according to current literature and clinical research studies. The book does not seek to duplicate or replace other current resources. Rather, it will create a comprehensive yet concise resource on this emerging topic that is not adequately covered by any current literature.

This textbook combines essential information on clinical cancer medicine with a guide to the latest advances in molecular oncology and tumor biology.

This textbook combines essential information on clinical cancer medicine with a guide to the latest advances in molecular oncology and tumor biology.

The development of immunotherapy in oncology field has revolutionized the prognosis of many types of cancer. The immune checkpoint inhibitors target receptors whose inhibition increases the activity of immune system cells against tumor cells. In recent years, new immunotherapies have been studied and approved in a growing number of tumors including melanoma, non-small cell lung cancer (NSCLC), and renal cell cancer (RCC). This volume provides a complete and updated state-of-art review regarding the management of cardiovascular toxicities from new immunotherapies. The manuscript is divided into different sections starting from the relationship between cancer and immune system to let the reader understand the new molecular concepts under immunotherapy development. Subsequent chapters describe specifically the immunotherapy options in solid tumor treatment and the main features of the immuno-related cardiovascular complications. This volume is written by experts in the oncological and cardiovascular fields and aims to provide to clinicians who approach current cancer patients a useful tool to move through the paths of modern cardio-oncology. An important section would afford the most relevant interventions needed to manage the cardiac events, suggesting how to reduce their impact and effects on oncological outcomes. The text concludes by addressing future perspectives in the cardio-immunology field, discussing many aspects such as the early detection of cardiovascular damage and the potential role of liquid biopsy in new damage-related biomarkers discovery.

The development of immunotherapy in oncology field has revolutionized the prognosis of many types of cancer. The immune checkpoint inhibitors target receptors whose inhibition increases the activity of immune system cells against tumor cells. In recent years, new immunotherapies have been studied and approved in a growing number of tumors including melanoma, non-small cell lung cancer (NSCLC), and renal cell cancer (RCC). This volume provides a complete and updated state-of-art review regarding the management of cardiovascular toxicities from new immunotherapies. The manuscript is divided into different sections starting from the relationship between cancer and immune system to let the reader understand the new molecular concepts under immunotherapy development. Subsequent chapters describe specifically the immunotherapy options in solid tumor treatment and the main features of the immuno-related cardiovascular complications. This volume is written by experts in the oncological and cardiovascular fields and aims to provide to clinicians who approach current cancer patients a useful tool to move through the paths of modern cardio-oncology. An important section would afford the most relevant interventions needed to manage the cardiac events, suggesting how to reduce their impact and effects on oncological outcomes. The text concludes by addressing future perspectives in the cardio-immunology field, discussing many aspects such as the early detection of cardiovascular damage and the potential role of liquid biopsy in new damage-related biomarkers discovery.

This book draws a connection between ethics and research across social sciences, philosophy, medical sciences and legal sciences, and demonstrates that any research activity needs to be conducted by means of rules deriving from the field of ethics.

This book draws a connection between ethics and research across social sciences, philosophy, medical sciences and legal sciences, and demonstrates that any research activity needs to be conducted by means of rules deriving from the field of ethics.

Badekultur und Muße stehen seit jeher in einem spannungsvollen Zusammenhang, weil sowohl die Praktiken des Badens als auch die gesellschaftliche Bewertung von Muße erheblichen Schwankungen unterworfen waren. Die Vorstellungen darüber, ob, wann, wie, in welcher Art und mit welchem Nutzen zu baden sei, wandelten sich ständig und fanden Niederschlag in mannigfaltigen kulturellen Zeugnissen, welche in den hier versammelten Beiträgen aus Kunstgeschichte, Archäologie, Mediävistik, Musikwissenschaft und Literaturwissenschaft untersucht werden. Die Beiträge des vorliegenden Bandes geben einen Überblick über Badekultur, Badeanlagen und Badepraktiken von der Antike bis zur Moderne und wollen darüber hinaus zur weitergehenden Erforschung dieses bislang eher stiefmütterlich behandelten Themenkomplexes anregen. Behandelt werden mit den Badeanlagen im antiken Baiae oder mit Zumthors Therme in Vals der räumlich-architektonische Rahmen des Badens. Die Auswertung literarischer und medizinischer Schriften rückt moralische und gesundheitliche Fragen in den Blick. Außerdem werden größere badekulturelle Zusammenhänge in der Antike, in der höfischen Kultur des Hoch- und Spätmittelalters sowie in den Kurorten des 19. Jahrhunderts verdeutlicht.

The book provide a unique and valuable resource on the clinical relevance of liquid biopsy as well as on the technical aspects of liquid biopsy analysis.

The book provide a unique and valuable resource on the clinical relevance of liquid biopsy as well as on the technical aspects of liquid biopsy analysis.

This proposed text is designed to provide a useful and comprehensive resource and state-of-the-art overview to readers about vascular damage  potentially induced by antineoplastic drugs. Thanks to more and more effective antineoplastic treatments the survival of cancer patients is enormously increasing, but at the same time it is increasing the burden of related cardiovascular complications that affect morbidity and mortality. On this basis a new branch of cardiology has been developed, that is Cardio-Oncology. The aim is to prevent cardiovascular complications related to cancer therapy and to facilitate and avoid interruption of antineoplastic drugs due to the occurrence of cardiovascular damage. An increasing attention has been given to cardiac damage, while, until today, vascular complications have been poorly evaluated. The aim of this book is to focus on vascular complications related to cancer treatment, to guide the clinician at facing,during his every day practice, cardiovascular toxicity in cancer and hematologic patients. The proposed sections of the book have been structured to review the molecular mechanisms underlying vascular damage induced by new and old treatments, to describe the various manifestations of vascular disease that may range from artery to venous disease (including coronary artery disease, peripheral arterial disease, venous thromboembolism and pulmonary hypertension), and to provide advice to monitor patients undergoing onco-hematologic treatments in order to prevent and eventually manage vascular damage.This book will address resident and fellow physicians, medical oncologists, cardiologists, general practitioners and all those who take care of these patients.All invited authors will be recognized experts in their field, and leading international researchers on these topics. The editor has worked with these expert colleagues on a variety of other projects.The authors will provide their manuscript according to current literature and clinical research studies. The book does not seek to duplicate or replace other current resources. Rather, it will create a comprehensive yet concise resource on this emerging topic that is not adequately covered by any current literature.