Antony Williams - Böcker

For consultants, facilitators or OD specialists, a house’s familiar image will help their clients see, think and feel their ways solving their business issues. No need for dry and hard-to-remember management schemas. The striking visual and active methods shown here deeply engage clients – they get it right away. The House and its ‘Rooms’ make sense to them, and they willingly start working with you.The Our House model has many of these ‘Rooms’ where complex business issues are sorted into one area at a time. The focus, the mood and the process vary with each Room, and the author reveals an entirely original consulting process each time. Disciplined creativity begins: loosening the grip of the past in the Attic; testing business foundations in the Cellar; preparing a meal the customer would love in the Kitchen; suppliers, maintenance and low-hanging fruit in the Garden; the team's dirty washing in the Laundry; elimination and waste goes into the Toilet; frank talk and vision alignment take place at the Dining Table; big systems perspectives can be seen from the Balcony; analysis in the Study; conversation and connection in the Living Room.The simplicity of the images of a House and its Rooms belies their frugality and their strength. In each Room, your clients are put through something demanding yet liberating. They see things differently and they see different things. Our House shows you how to succeed with simple action methods that are enlightening and strong.

For consultants, facilitators or OD specialists, a house’s familiar image will help their clients see, think and feel their ways solving their business issues. No need for dry and hard-to-remember management schemas. The striking visual and active methods shown here deeply engage clients – they get it right away. The House and its ‘Rooms’ make sense to them, and they willingly start working with you.The Our House model has many of these ‘Rooms’ where complex business issues are sorted into one area at a time. The focus, the mood and the process vary with each Room, and the author reveals an entirely original consulting process each time. Disciplined creativity begins: loosening the grip of the past in the Attic; testing business foundations in the Cellar; preparing a meal the customer would love in the Kitchen; suppliers, maintenance and low-hanging fruit in the Garden; the team's dirty washing in the Laundry; elimination and waste goes into the Toilet; frank talk and vision alignment take place at the Dining Table; big systems perspectives can be seen from the Balcony; analysis in the Study; conversation and connection in the Living Room.The simplicity of the images of a House and its Rooms belies their frugality and their strength. In each Room, your clients are put through something demanding yet liberating. They see things differently and they see different things. Our House shows you how to succeed with simple action methods that are enlightening and strong.

Strychnine’s poisonous nature was known in 16th century Europe, and the alkaloid was isolated in pure form for the first time in 1818. Then began a more than century-long quest to unravel the structure of strychnine that led to two Nobel prizes, clearly without the assistance of the modern spectroscopic methods to which we now have access. In his 1963 report of the synthesis, Woodward said, "The tangled skein of atoms which constitutes its molecule provided a fascinating structural problem that was pursued intensively during the century just past, and was solved finally only within the last decade." The structure elucidation of complex natural products is facilitated today by access to modern instrumentation and experimental techniques. Using a modern 600 MHz NMR spectrometer equipped with a 1.7 mm cryogenic probe and a 1 mg sample, it is now possible to acquire a comprehensive suite of 2D NMR spectra that rigorously characterizes the complex structure of strychnine in a scant 24 hours. When the 2D NMR data are combined with Computer-Assisted Structure Elucidation methods, the structure can be solved in mere seconds. It is against this historical backdrop that these two volumes regarding the Structure Elucidation of Natural Products by NMR is set.Volume 1 discusses contemporary NMR approaches including optimized and future hardware and experimental approaches to obtain both the highest quality and most appropriate spectral data for analysis. Volume 2 considers data processing and algorithmic based analyses tailored to natural product structure elucidation and reviews the application of NMR to the analysis of a series of different natural product families including marine natural products, terpenes, steroids, and carbohydrates. These books, bringing together acknowledged experts, uniquely focus on the combination of experimental approaches and modern hardware and software applied to the structure elucidation of natural products. The volumes will be an essential resource for NMR spectroscopists, natural product chemists and industrial researchers working on natural product analysis or the characterization of impurities and degradation products of pharmaceuticals that can be scarce as natural product samples.

The Ghanian plant Cryptolepis sanguinolenta is the source of a series of fascinating indoloquinoline alkaloids. The most unusual member of this alkaloid series was initially proposed to be a spiro nonacyclic structure, named cryptospirolepine, and was elucidated in 1993 based on the technologies available at that time. There were, however, several annoying attributes to the structure that bothered analysts for the ensuing 22 years. During the two decades that followed the initial work there have been enormous developments in NMR technology. Using new experimental approaches, specifically homodecoupled 1,1- and 1,n-HD-ADEQUATE NMR experiments developed in 2014, the structure of only a 700 µg sample of cryptospirolepine has been revised and is shown on the cover of this volume. The confluence of the NMR technological and methodological advances that allowed the revision of the structure of cryptospirolepine using a submilligram sample seems a fitting example for this book, which is dedicated to the NMR characterization of various classes of natural products. Volume 2 considers data processing and algorithmic based analyses tailored to natural product structure elucidation and reviews the application of NMR to the analysis of a series of different natural product families including marine natural products, terpenes, steroids, alkaloids and carbohydrates. Volume 1 discusses contemporary NMR approaches including optimized and future hardware and experimental approaches to obtain both the highest quality and most appropriate spectral data for analysis. These books, bringing together acknowledged experts, uniquely focus on the combination of experimental approaches and modern hardware and software applied to the structure elucidation of natural products. The volumes will be an essential resource for NMR spectroscopists, natural product chemists and industrial researchers working on natural product analysis or the characterization of impurities and degradation products of pharmaceuticals that can be as scarce as natural product samples.

Computer-Assisted Structure Elucidation (CASE) systems are a combination of software algorithms and tools to support and enable chemists and spectroscopists engaged in the process of molecular structure elucidation via the analysis of spectroscopic data. These expert systems dramatically reduce the time associated with structure elucidation and improve the reliability of the results. Contemporary Computer-Assisted Approaches to Molecular Structure Elucidation describes the principles on which these expert systems for spectroscopic structure elucidation are based and concisely explains the algorithmic concepts behind the programs. The authors use their own personal experiences in the development of the Structure Elucidator (StrucEluc) CASE software system to discuss the present state-of-the-art in computer-assisted structure elucidation. Scientists that are presently using CASE systems will be interested in the algorithms and modern approaches and for organizations that are currently using the StrucEluc platform the book is designed to help researchers understand the strategies behind CASE as well as details regarding the StrucEluc platform. For scientists that have never used CASE systems they will now have access to all necessary information to understand CASE systems for mastering this new and very effective approach to structure elucidation. The authors overall goal is writing this book is to produce the 'must read' definitive text that will represent the results of decades of work to develop computer-assisted structure elucidation software systems. CASE systems are now powerful software tools commonly outperforming and correcting human interpretations of data. This book will also provide an historical perspective of the work of the founding fathers of the technique and identify the challenges that have been overcome to produce modern CASE systems.