Balachandar Vellingiri – författare

Researchers use brain organoids to study the formation of neural tissues, investigate the processes involved in brain development, and gain a better understanding of neurological disorders and diseases. Brain organoids are particularly useful in studying developmental disorders, neurodegenerative diseases, and infectious diseases that affect the brain. Fundamental of Brain Organoids for Neurological Diseases provides a practical resource for researchers on how to utilize and apply brain organoids. This book is organized into nine distinct sections, guiding the reader through each step from advanced overview of what organoids are to the use of brain organoids in various neurodevelopmental disorders and neurodegenerative diseases. In later sections, this book reviews the necessary methods involved in organoid development including the elements and challenges involved. This book will serve as a valuable tool for researchers, helping to advance the understanding of brain biology and disease mechanisms.Presents the steps involved in the generation of brain organoids from HiPSCs onwardsSummarizes the importance of organoids in understanding various neurodevelopmental disordersReviews the ongoing clinical trials using brain organoidsDiscusses ethical considerations when conducting organoid research

Role of Gut Microbiome in Neurodegenerative Disorders provides an overview of the gut microbiota and its interactions with the gut and the central nervous system. This book reviews the relevance of this axis to the pathogenesis of neurodegenerative diseases, such as Parkinson’s disease (PD), Alzheimer’s disease (AD), and Multiple sclerosis (MS). Various chapters discuss the effects of gut derived particles in various parts of brain and the targeting pathways leading to protein deposition in brain.Reviews the pathology and pathophysiology of gut derived neuropeptides in neurodegenerative disordersDiscusses mechanism of gut derivatives on immune systemPresents possible therapy mechanism using gut microbiome

Epigenetics and miRNA in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications explores the crucial role of epigenetic modifications and microRNAs in the onset, progression, and treatment of neurodegenerative disorders such as Alzheimer’s, Parkinson’s, ALS, and Huntington’s disease. This comprehensive book bridges cutting-edge molecular research with real-world clinical applications, covering biomarker discovery, novel therapeutics, gene editing, and AI-driven bioinformatics. With clear explanations, case studies, and future perspectives, it serves as an essential resource for researchers, clinicians, and biotech professionals working toward innovative solutions for neurodegenerative disease diagnosis and treatmentIntegrates perspectives from neuroscience, molecular biology, clinical medicine, and bioinformaticsCovers fundamental molecular mechanisms, disease specific applications, and translational research, appealing to both researchers and cliniciansProvides practical examples of epigenetic and miRNA research as applied to neurodegenerative diseases, aiding in real-world implementation