Benjamin Yakir - Böcker

Gene mapping is used in experimental genetics to improve the hardiness or productivity of animals or plants of agricultural value, to explore basic mechanisms of inheritance, or to study animal models of human inheritance. In human populations it is used as a first step to identify genes associated with human health and disease. This book presents a unified discussion of the statistical concepts applied in gene mapping, first in the experimental context of crosses of inbred lines and then in outbred populations, primarily humans. The development involves elementary principles of probability and statistics, which are implemented by computational tools based on the R programming language to simulate genetic experiments and evaluate statistical analyses. The viewpoint reflects the modern approach of using anonymous DNA markers distributed throughout the genome to identify regions likely to contain genes of interest. The reader is assumed to have some familiarity with probability/statistics and with elementary genetics. Important topics are reviewed in the first three chapters. The R programming language is developed in the text. Each chapter contains exercises, both theoretical and computational, some routine and others that are more challenging. The book is suitable for upper level undergraduate students or graduate students of genetics or statistics.

Presents a useful new technique for analyzing the extreme-value behaviour of random fieldsModern science typically involves the analysis of increasingly complex data. The extreme values that emerge in the statistical analysis of complex data are often of particular interest. This book focuses on the analytical approximations of the statistical significance of extreme values. Several relatively complex applications of the technique to problems that emerge in practical situations are presented.  All the examples are difficult to analyze using classical methods, and as a result, the author presents a novel technique, designed to be more accessible to the user.Extreme value analysis is widely applied in areas such as operational research, bioinformatics, computer science, finance and many other disciplines. This book will be useful for scientists, engineers and advanced graduate students who need to develop their own statistical tools for the analysis of their data. Whilst this book may not provide the reader with the specific answer it will inspire them to rethink their problem in the context of random fields, apply the method, and produce a solution.