Science lost one of its distinguished researchers in the fields of biological psychiatry and neuropsychopharmacology on March 4, 1975, with the death of Harold Himwich. Some of his colleagues, friends, and former associates have expressed their esteem for this gentle person by the contribution of chapters in this book. Since this book can represent only an incomplete indication of Harold Himwich''s influence, the editors have included his complete bibliography at the end of this volume. Harold Himwich''s research career was divided into several phases, some of which overlapped. Starting with his first paper on rhabdomyoma of the ovary in 1920, he was entranced by research as well as by the puzzles and results which it promised. During the period that he was a resident and house officer at Bellevue Hospital in New York, he studied the physiology of muscular exercise. This work led him into studies of exercise in various types of disease. With Meyerhoff in Kiel, Germany, he began studying the respiratory quotient of muscle, and after returning to this country, he produced a number of papers on respiratory quotients of various organs including the brain.

Science lost one of its distinguished researchers in the fields of biological psychiatry and neuropsychopharmacology on March 4, 1975, with the death of Harold Himwich. Some of his colleagues, friends, and former associates have expressed their esteem for this gentle person by the contribution of chapters in this book. Since this book can represent only an incomplete indication of Harold Himwich's influence, the editors have included his complete bibliography at the end of this volume. Harold Himwich's research career was divided into several phases, some of which overlapped. Starting with his first paper on rhabdomyoma of the ovary in 1920, he was entranced by research as well as by the puzzles and results which it promised. During the period that he was a resident and house officer at Bellevue Hospital in New York, he studied the physiology of muscular exercise. This work led him into studies of exercise in various types of disease. With Meyerhoff in Kiel, Germany, he began studying the respiratory quotient of muscle, and after returning to this country, he produced a number of papers on respiratory quotients of various organs including the brain.

The vast growth of knowledge in recent years concerning the functional role of serotonergic systems in central nervous system function prompted the organization of the symposium. The organiz­ ing committees felt at the onset that the field of serotonin research had grown so rapidly that it would be impossible to cover every aspect of it in individual symposia. Thus it was felt that certain areas of research had to be omitted due to time constraints, and we extend an apology to the researchers in areas not included in these proceedings. Rather it was hoped to provide a balance overview of the field, starting with the anatomy of serotonergic systems and proceeding to the level of the serotonergic receptors at the cell membrane, and then inside the neuron to discuss the regulation of serotonin bisynthesis and integration within indole­ mine systems. The functional aspects of serotonergic transmission focused on the emerging role of this amine in the processing of nociceptive information, singly or in tandem with other neurotran­ smitters or neuromodulators. A separate symposium dealt with a variety of animal models suitable for the analysis of the role of serotonin in behavior, and finally led to the evaluation of serotonin metabolism in the study of abnormal human behavior. The editors would like to dedicate these proceedings on /Serotonin - Current Aspects of Neurochemistry and Function/ to two pioneers in this field, Dr. Irving Page and Dr. Maurice Rapport.

Science lost one of its distinguished researchers in the fields of biological psychiatry and neuropsychopharmacology on March 4, 1975, with the death of Harold Himwich. Some of his colleagues, friends, and former associates have expressed their esteem for this gentle person by the contribution of chapters in this book. Since this book can represent only an incomplete indication of Harold Himwich''s influence, the editors have included his complete bibliography at the end of this volume. Harold Himwich''s research career was divided into several phases, some of which overlapped. Starting with his first paper on rhabdomyoma of the ovary in 1920, he was entranced by research as well as by the puzzles and results which it promised. During the period that he was a resident and house officer at Bellevue Hospital in New York, he studied the physiology of muscular exercise. This work led him into studies of exercise in various types of disease. With Meyerhoff in Kiel, Germany, he began studying the respiratory quotient of muscle, and after returning to this country, he produced a number of papers on respiratory quotients of various organs including the brain.

Science lost one of its distinguished researchers in the fields of biological psychiatry and neuropsychopharmacology on March 4, 1975, with the death of Harold Himwich. Some of his colleagues, friends, and former associates have expressed their esteem for this gentle person by the contribution of chapters in this book. Since this book can represent only an incomplete indication of Harold Himwich's influence, the editors have included his complete bibliography at the end of this volume. Harold Himwich's research career was divided into several phases, some of which overlapped. Starting with his first paper on rhabdomyoma of the ovary in 1920, he was entranced by research as well as by the puzzles and results which it promised. During the period that he was a resident and house officer at Bellevue Hospital in New York, he studied the physiology of muscular exercise. This work led him into studies of exercise in various types of disease. With Meyerhoff in Kiel, Germany, he began studying the respiratory quotient of muscle, and after returning to this country, he produced a number of papers on respiratory quotients of various organs including the brain.

The vast growth of knowledge in recent years concerning the functional role of serotonergic systems in central nervous system function prompted the organization of the symposium. The organiz­ ing committees felt at the onset that the field of serotonin research had grown so rapidly that it would be impossible to cover every aspect of it in individual symposia. Thus it was felt that certain areas of research had to be omitted due to time constraints, and we extend an apology to the researchers in areas not included in these proceedings. Rather it was hoped to provide a balance overview of the field, starting with the anatomy of serotonergic systems and proceeding to the level of the serotonergic receptors at the cell membrane, and then inside the neuron to discuss the regulation of serotonin bisynthesis and integration within indole­ mine systems. The functional aspects of serotonergic transmission focused on the emerging role of this amine in the processing of nociceptive information, singly or in tandem with other neurotran­ smitters or neuromodulators. A separate symposium dealt with a variety of animal models suitable for the analysis of the role of serotonin in behavior, and finally led to the evaluation of serotonin metabolism in the study of abnormal human behavior. The editors would like to dedicate these proceedings on /Serotonin - Current Aspects of Neurochemistry and Function/ to two pioneers in this field, Dr. Irving Page and Dr. Maurice Rapport.