Bojidarka Ivanova – författare & böcker

Linearly Polarized IR Spectroscopy

Theory and Applications for Structural Analysis

E-bok

Engelska, 2024

1 282 kr

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A technique that is useful in the study of pharmaceutical products and biological molecules, polarization IR spectroscopy has undergone continuous development since it first emerged almost 100 years ago. Capturing the state of the science as it exists today, Linearly Polarized IR Spectroscopy: Theory and Applications for Structural Analysis demonstrates how the technique can be properly utilized to obtain important information about the structure and spectral properties of oriented compounds.

The book starts with the theoretical basis of linear-dichroic infrared (IR-LD) spectroscopy and then moves on to examine the background of the orientation method of colloid suspensions in a nematic host. It explores the orientation procedure itself, experimental design, and mathematical tools for the interpretation of the IR spectroscopic patterns. Next, the authors describe the structural elucidation of inorganic and organic compounds and glasses. Finally, they discuss applications in pharmaceutical analysis and the chemistry of dyes. Filled with more than 140 illustrations along with a color insert, the book explains both the scope of the polarized IR spectroscopy method as well as its limitations.

A powerful source of information not only for specialists in IR spectroscopy, but also for those working in the field of structural analysis, this volume moves the field closer to developing an inherently classical method for the structural characterization of compounds.

Linearly Polarized IR Spectroscopy

Theory and Applications for Structural Analysis

AvTsonko Kolev,Bojidarka Ivanova

E-bok

PDF, Engelska, 2024

1 293 kr

Läs direkt efter köp

A technique that is useful in the study of pharmaceutical products and biological molecules, polarization IR spectroscopy has undergone continuous development since it first emerged almost 100 years ago. Capturing the state of the science as it exists today, Linearly Polarized IR Spectroscopy: Theory and Applications for Structural Analysis demonstrates how the technique can be properly utilized to obtain important information about the structure and spectral properties of oriented compounds.

The book starts with the theoretical basis of linear-dichroic infrared (IR-LD) spectroscopy and then moves on to examine the background of the orientation method of colloid suspensions in a nematic host. It explores the orientation procedure itself, experimental design, and mathematical tools for the interpretation of the IR spectroscopic patterns. Next, the authors describe the structural elucidation of inorganic and organic compounds and glasses. Finally, they discuss applications in pharmaceutical analysis and the chemistry of dyes. Filled with more than 140 illustrations along with a color insert, the book explains both the scope of the polarized IR spectroscopy method as well as its limitations.

A powerful source of information not only for specialists in IR spectroscopy, but also for those working in the field of structural analysis, this volume moves the field closer to developing an inherently classical method for the structural characterization of compounds.

Linearly Polarized IR Spectroscopy

Theory and Applications for Structural Analysis

AvBojidarka Ivanova,Tsonko Kolev

Häftad, Engelska, 2019

1 100 kr

Skickas inom 10-15 vardagar

A technique that is useful in the study of pharmaceutical products and biological molecules, polarization IR spectroscopy has undergone continuous development since it first emerged almost 100 years ago. Capturing the state of the science as it exists today, Linearly Polarized IR Spectroscopy: Theory and Applications for Structural Analysis demonstrates how the technique can be properly utilized to obtain important information about the structure and spectral properties of oriented compounds.The book starts with the theoretical basis of linear-dichroic infrared (IR-LD) spectroscopy and then moves on to examine the background of the orientation method of colloid suspensions in a nematic host. It explores the orientation procedure itself, experimental design, and mathematical tools for the interpretation of the IR spectroscopic patterns. Next, the authors describe the structural elucidation of inorganic and organic compounds and glasses. Finally, they discuss applications in pharmaceutical analysis and the chemistry of dyes. Filled with more than 140 illustrations along with a color insert, the book explains both the scope of the polarized IR spectroscopy method as well as its limitations.A powerful source of information not only for specialists in IR spectroscopy, but also for those working in the field of structural analysis, this volume moves the field closer to developing an inherently classical method for the structural characterization of compounds.

Linearly Polarized IR Spectroscopy

Theory and Applications for Structural Analysis

AvBojidarka Ivanova,Tsonko Kolev

Inbunden, Engelska, 2011

3 050 kr

Skickas inom 10-15 vardagar

A technique that is useful in the study of pharmaceutical products and biological molecules, polarization IR spectroscopy has undergone continuous development since it first emerged almost 100 years ago. Capturing the state of the science as it exists today, Linearly Polarized IR Spectroscopy: Theory and Applications for Structural Analysis demonstrates how the technique can be properly utilized to obtain important information about the structure and spectral properties of oriented compounds.The book starts with the theoretical basis of linear-dichroic infrared (IR-LD) spectroscopy and then moves on to examine the background of the orientation method of colloid suspensions in a nematic host. It explores the orientation procedure itself, experimental design, and mathematical tools for the interpretation of the IR spectroscopic patterns. Next, the authors describe the structural elucidation of inorganic and organic compounds and glasses. Finally, they discuss applications in pharmaceutical analysis and the chemistry of dyes. Filled with more than 140 illustrations along with a color insert, the book explains both the scope of the polarized IR spectroscopy method as well as its limitations.A powerful source of information not only for specialists in IR spectroscopy, but also for those working in the field of structural analysis, this volume moves the field closer to developing an inherently classical method for the structural characterization of compounds.

Experimental and Theoretical Mass Spectrometric Quantification of Non-Covalent Interactions in High Order Homogeneous Self-Associates of Nucleobases and Nucleosides

AvBojidarka Ivanova

E-bok

PDF, Engelska, 2018

1 680 kr

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It is widely accepted that the quadruplex, representing a supramolecular self-aggregate of guanine (G) containing recurrent units of four noncovalent interacting nucleobases (NBs) and one monovalent cation in DNA and RNA, has been associated with genome instability, transcription and replication of living cells. This line of inquiry has also evidenced experimentally associates such as quartets of uracil (U), adenine (A) and thymine as well as a tetramer, consisting of guanine:cytosine (G:C:G:C) NBs, respectively. In (C)-rich DNA sequences, a tetraplex of stacked hemi-protonated (C):(C) pairs ('i-motif') has been involved in regulatory gene expression. The supramolecular self-aggregates are promising drug targets implicated in cancer and other diseases. However, the authors argue in this chapter that there is still much research required in order to understand fundamental molecular forces and factors, determining the binding affinity and thermodynamic stability of non-covalent interacting NBs both in vitro and in vivo. Arguably, no less than an elucidation will allow us to shed light on molecular level mechanisms governing the supramolecular self-aggregation. To examine these issues, the authors perform mass spectrometric (MS) quantification of molecular noncovalent interactions of NBs and nucleosides (NSs) uridine (1), cytidine (2), guanosine (3) and N,N-dimethyl guanosine (4), respectively. They survey several methods concerning the study such as ultra-high resolution electrospray ionization (ESI), atmospheric pressure chemical ionization (APCI) and matrix assisted laser desorption-ionization (MALDI) methods in a single operation mode, coupled with collision induced dissociation (CID) mass spectrometry. The theoretical treatment includes high accuracy static and molecular dynamic (MD) quantum chemistry. Ab initio methods and density functional theory (DFT) are used. Stochastic dynamics based on the Box-Muller (BM) method is adopted determining experimental diffusion parameters of MS ions of non-covalent interacting species. They are correlated with experimental diffusion data using the "e;current monitoring method"e; and theoretical parameters obtained from Arrhenius's formalism. There are two foci for this study. The first issue is which equation models connect experimental kinetic, thermodynamic and diffusion parameters with theoretical quantum chemical data about 3D structures of analytes? The second issue deals with the statistical claim that the presented models use their own experimental and theoretical MS results. Chemometrics, in order to be confident that there is a real functional relationship of experiment and theory, is used. In this context, the great importance of this complex analysis for the development of the "e;structural analytical chemistry"e; is undeniable.