Bruce L. Miller - Böcker

This foundational work comprehensively examines the current state of the genetics, genomics and brain circuitry of psychiatric and neurological disorders. It consolidates discoveries of specific genes and genomic regions associated with these conditions, the genetic and anatomic architecture of these syndromes, and addresses how recent advances in genomics are leading to a reappraisal of the biology underlying clinical neuroscience. In doing so, it critically examines the promise and limitations of these discoveries toward treatment, and to the interdisciplinary nature of understanding brain and behavior. Coverage includes new discoveries regarding autism, epilepsy, intellectual disability, dementias, movement disorders, language impairment, disorders of attention, schizophrenia, and bipolar disorder. Genomics, Circuits, and Pathways in Clinical Neuropsychiatry focuses on key concepts, challenges, findings, and methods in genetics, genomics, molecular pathways, brain circuitry, and related neurobiology of neurologic and psychiatric disorders.

Provides interdisciplinary appeal in psychiatry, neurology, neuroscience, and genetics Identifies key concepts, methods, and findings Includes coverage of multiple disorders from autism to schizophrenia Reviews specific genes associated with disorders Discusses the genetic architecture of these syndromes Explains how recent findings are influencing the understanding of biology Clarifies the promise of these findings for future treatment

Frontotemporal Dementia provides an in-depth look at the history, various types, genetics, neuropathology and psychosocial aspects of one of the most common but least understood causes of dementia, frontotemporal lobar degeneration, from one of the world's leading centers for the study of dementia. Aided by the latest research in diagnosis, mechanism and treatment, this book captures the rich and quickly changing landscape of a devastating neurodegenerative disease, and offers up-to-date clinical advice for patient care. Frontotemporal dementia, in particular, raises psychological and philosophical questions about the nature of self, free will, emotion, art and behavior - important topics for practitioners and families to appreciate as they care for the sufferer. This book includes case studies, photographs and figures from the leaders in the field and personal communication from the researchers driving these developments.

This volume presents a comprehensive guide to one of the most important goals of neuroscience, establishing precision structure-function relationships in the brain. Progressing from the early stages of research, specifically the advent of computerized tomography and later, magnetic resonance imaging, this invaluable resource will take clinicians on an all encompassing journey into the ways different fields of neurology can work together to advance our understanding of brain disorders.

Complex topics including the neurochemistry of cognition, neuropsychology of aging and dementia, disorders of semantic memory, working memory, and the dysexecutive syndromes, amongst others, are thoroughly discussed and presented.

Clinicians will find a state-of-the-art reference guide that can be used to further understand how the fields of neuropsychology and behavioral neurology can complement each other to produce advancements in the neurosciences.

Comprehensive information on the ways neuropsychology and behavioral neurology can work together to advance researchComplex topics that explore the neurochemistry of cognition, the neuropsychology of aging and dementia, and disorders of semantic memory, amongst othersImportant breakthroughs in brain mapping techniques that have advanced diagnosis and patient care management within the neurosciences

Mysteries of the Social Brain describes the scientific underpinnings of human behavior and values. Through the retelling of fascinating clinical stories of people with neurological conditions, this book explores the parts of the brain that allow humans to thrive as social and creative beings. The authors reveal the relevance of our brain circuits to our well‑being—and the well‑being of our societies—and show what happens when changes in our brain circuitry drive changes in empathy, altruism, moral beliefs, and creativity.By integrating perspectives from neurology, psychology, psychiatry, and neuroscience, the stories in this book offer novel insights into the inner workings of the social brain and reveal groundbreaking findings from work in frontotemporal dementia, emotion, and the science of human values. This book showcases the novel discovery that creativity can emerge when there is decline in the brain’s language systems, a finding that highlights the robust, yet underappreciated connections between science and art. Readers will learn about the biological basis of social behavior as well as simple steps that they can take to improve the functioning of their own social brains.Miller and Sturm take us on an engaging dive into the field of behavioral neurology and neuroscience, exploring what we can learn from people with neurological conditions, and revealing the ways that neuroscience can change societies for the better. It will captivate general readers as well as clinicians and scientists who are interested in human social behavior, cognition, and emotion.

Mysteries of the Social Brain describes the scientific underpinnings of human behavior and values. Through the retelling of fascinating clinical stories of people with neurological conditions, this book explores the parts of the brain that allow humans to thrive as social and creative beings. The authors reveal the relevance of our brain circuits to our well‑being—and the well‑being of our societies—and show what happens when changes in our brain circuitry drive changes in empathy, altruism, moral beliefs, and creativity.By integrating perspectives from neurology, psychology, psychiatry, and neuroscience, the stories in this book offer novel insights into the inner workings of the social brain and reveal groundbreaking findings from work in frontotemporal dementia, emotion, and the science of human values. This book showcases the novel discovery that creativity can emerge when there is decline in the brain’s language systems, a finding that highlights the robust, yet underappreciated connections between science and art. Readers will learn about the biological basis of social behavior as well as simple steps that they can take to improve the functioning of their own social brains.Miller and Sturm take us on an engaging dive into the field of behavioral neurology and neuroscience, exploring what we can learn from people with neurological conditions, and revealing the ways that neuroscience can change societies for the better. It will captivate general readers as well as clinicians and scientists who are interested in human social behavior, cognition, and emotion.

Most people who develop dementia will never be diagnosed, and therefore lack access to treatment and care from specialists in the field. This new edition provides updated guidance on how behavioral symptom reflect the changes occurring in the brain, and how these can help generalist clinicians to accurately diagnose neurodegenerative diseases. This practical book is aimed at healthcare professionals working in neurology, psychiatry and neuropsychology wanting to enhance the skills and knowledge needed to successfully manage these diseases. Simple approaches to bedside mental status testing, differential diagnosis and treatment, and interpreting neuropsychological testing and neuroimaging findings are covered. Introductory chapters outline dementia epidemiology and dementia neuropathology whilst chapters new to this edition describe the improvements in diagnostic capabilities in recent years, including blood based and cerebrospinal biomarkers and emerging biologically based therapies. Chapters on sleep disorders, and chronic traumatic encephalopathy and traumatic brain injury have also been expanded.