C. Chagas – författare

Mammalian Cytogenetics and Related Problems in Radiobiology covers the proceedings of a symposium held in Sao Paulo and Rio de Janeiro, Brazil in October 1962. The book focuses on the processes, methodologies, and approaches involved in mammalian cytogenetics and radiobiology. The selection first offers information on the nutrition and metabolism of cultured mammalian cells, blood technique and human chromosomes, and DNA replication in human chromosomes. Discussions focus on replication of heterochromatin in the human male; difficulties involved in the study of DNA synthesis in human chromosomes; and perspectives for future research. The text then ponders on the progress in the utilization of cell culture techniques for studies in mammalian and human somatic cell genetics and modification of radiation effects in the Ehrlich ascites tumor by oxygen or sodium azide. The manuscript examines experimental studies on mammalian chromosome aberrations, chromosome breakage in vitro, and survival of human cells in tissue culture after irradiation with densely and sparsely ionizing radiation. The text then elaborates on the observations on the morphology and behavior of normal human chromosomes, human pachytene chromosomes, and abnormalities of autosomes. The selection is a vital reference for readers interested in mammalian cytogenetics and radiobiology.

List of the Participants Xl Audience of the Holy Father XVll SCIENTIFIC PAPERS Introductory Remarks. Electrostatics and Specificity III Nucleic Acid Reactions (B. Pullman)...1 Theoretical Studies of Molecular Recognition and Ca- lysis by Enzymes (H. A. Scheraga) ...21 Molecular Dynamics of the DNA Double Helix (M. Levitt) 43 Simulating the Energetics and Dynamics of Enzymatic Reactions (A. Warshel) ...59 Structural Studies of DNA-Protein Interactions (B. W. Matthews) ...83 Protein-Nucleic Acid Interactions, Models and Reality (W. Saenger) ...*...99 Studying Enzyme-Substrate Interactions by Site-Directed Mutagenesis (A. R. Fersht and G. Winter) ...123 Sequence Dependence of DNA Conformation, Dynamics and Interactions in Solution (D. ]. Patel, S. A. Kozlowski, A. Pardi, R. Bhatt, S. Ikuta and K. Itakura) 133 Elements of Specific Recognition of Non-Intercalating - gands in the Interaction with DNA (C. Zimmer and G. Luck) ...175 VIlI PONTIFICIAE ACADEMIAE SCIENTIARUM SCRIPTA VARIA 55 Interactions of Transfer RNAs with their Biological Partners (J. P. Ebel, R. Giege, D. Moras and P. Remy) 207 Antibody Structure and Specificity (D. R. Davies) .249 Specificity of Ionophore-Cation Interaction (Yu. A. - chinnikov and V. T. Ivanov) " ...263 Theoretical Analysis of Factors Responsible for Specificity in Ionophore-Cation Interactions (A. Pullman) 303 FOREWORD " The specificity of biological interactions" was the subject of a Study Group that met at the Pontifical Academy of Sciences from Novem- ber 9-11, 1983. This theme is one of the most advanced fields in modern biology.