Carlos A. Torres-Cabala – författare

This book discusses the molecular, biological, pathological, and clinical aspects of melanoma, with special emphasis in the new concepts of melanoma genetics. A multidisciplinary group of experts in Genetics, Dermatology, Pathology, and Melanoma Medical Oncology contribute state-of-the-art knowledge in melanoma research and clinical management, not only exposing the current status of knowledge of the topics but also providing their personal experiences and ideas about the future and potential practical application of the genetic aspects of melanoma. During the last few years we have witnessed an impressive amount of discoveries in the field of melanoma genetics which have changed our approach in understanding the pathogenesis and treatment of this lethal disease. Genetics of Melanoma is a practical approach to melanoma genetic mechanisms and their application in the diagnosis and treatment of this malignancy. It is an essential source of updated information and a powerful tool for clinicians, pathologists, and basic scientists who wish to understand, apply, and investigate the multiple new aspects of melanoma genetics.

This book discusses the molecular, biological, pathological, and clinical aspects of melanoma, with special emphasis in the new concepts of melanoma genetics. A multidisciplinary group of experts in Genetics, Dermatology, Pathology, and Melanoma Medical Oncology contribute state-of-the-art knowledge in melanoma research and clinical management, not only exposing the current status of knowledge of the topics but also providing their personal experiences and ideas about the future and potential practical application of the genetic aspects of melanoma. During the last few years we have witnessed an impressive amount of discoveries in the field of melanoma genetics which have changed our approach in understanding the pathogenesis and treatment of this lethal disease. Genetics of Melanoma is a practical approach to melanoma genetic mechanisms and their application in the diagnosis and treatment of this malignancy. It is an essential source of updated information and a powerful tool for clinicians, pathologists, and basic scientists who wish to understand, apply, and investigate the multiple new aspects of melanoma genetics.

Melanoma results in a significant social impact due to its relatively high mortality and young age of affected patients. During the last two decades there have been several crucial advances providing insight into the molecular alterations responsible for melanoma development. Thus, most melanomas can be classified within several pathways characterized by specific genetic abnormalities. This book describes the most important molecular features of melanocytic lesions with histologic factors that allow us to render a diagnosis of melanoma and related lesions, with special emphasis to the WHO classifications of melanocytic lesions. It serves as a review of the newest information related to the molecular characteristics of melanocytic lesions. Molecular diagnosis has become more vital to the diagnosis of melanomas and other melanocytic lesions, so this book is intended to provide a comprehensive yet concise understanding of emerging molecular advances. Chapters will cover a variety of lesions encountered in practice, including lentigo maligna, acral, mucosal, and desmoplastic melanomas. This text will also include clinical, histologic, and immunohistochemical images whenever appropriate.Precision Molecular Pathology of Melanocytic Lesions describes the current knowledge of melanocytic lesions and serves as an important resource for pathologists, dermatologists, oncologists, and researchers who treat and study patients affected by melanocytic tumors.