Carlos Lopez – författare

''You damn sadist/said mr cummings ''you try to make people think. '' -Ezra Pound (Canto 89) What makes herpesviruses unique? It is certainly not the size of their genomes or the individual features of their reproductive cycle, although in toto striking features that are exclusive to the herpesviruses abound. Unquestionably, the pre-eminent feature is the relationship of herpes­ viruses with their natural hosts. As described in preceding volumes, all herpesviruses seem to be able to colonize and to remain in a latent, nonproductive form for life of their hosts. Once established in the host, the relationship is best described as that of an armed truce. What happens when this truce breaks down or when the host encounters the virus for the first time is the subject of this volume. We have focused primarily on the five human herpesviruses [herpes simplex virus 1 (HSV-l), herpes simplex virus 2 (HSV-2), cytomegalovirus (CMV), varicella zoster virus (VZV) and Epstein-Barr virus (EBV)] because much more is known about them than about any other herpesviruses, and because it is of interest to compare both the diversity of manifestations of infections with human herpesviruses and the spectrum of human responses to these viruses. This volume summarizes the current knowledge of the pathogenesis and immunobiology of herpesvirus infections in man and describes new and developing approaches to prophylaxis and treatment. It contains con­ tributions from distinguished research scientists presently engaged at the forefront of these scientific investigations.

'You damn sadist/said mr cummings 'you try to make people think. ' -Ezra Pound (Canto 89) What makes herpesviruses unique? It is certainly not the size of their genomes or the individual features of their reproductive cycle, although in toto striking features that are exclusive to the herpesviruses abound. Unquestionably, the pre-eminent feature is the relationship of herpes­ viruses with their natural hosts. As described in preceding volumes, all herpesviruses seem to be able to colonize and to remain in a latent, nonproductive form for life of their hosts. Once established in the host, the relationship is best described as that of an armed truce. What happens when this truce breaks down or when the host encounters the virus for the first time is the subject of this volume. We have focused primarily on the five human herpesviruses [herpes simplex virus 1 (HSV-l), herpes simplex virus 2 (HSV-2), cytomegalovirus (CMV), varicella zoster virus (VZV) and Epstein-Barr virus (EBV)] because much more is known about them than about any other herpesviruses, and because it is of interest to compare both the diversity of manifestations of infections with human herpesviruses and the spectrum of human responses to these viruses. This volume summarizes the current knowledge of the pathogenesis and immunobiology of herpesvirus infections in man and describes new and developing approaches to prophylaxis and treatment. It contains con­ tributions from distinguished research scientists presently engaged at the forefront of these scientific investigations.

Shmuel, es el ms joven de los hijos de Zebedeo, el mayor de ellos fue Jacob quien despus conocemos tuvo un segundo nombre Santiago y otro hermano es Juan a quien se le llamara el amado. El naci al igual que sus hermanos en Nazaret. A una corta edad a invitacin de su padre Zebedeo, acuden a recibir a familiares cercanos quienes regresaban de Alejandra: Era la familia de un primo, Jos, casado con Mara y fue en esa ocasin cuando tuvieron la oportunidad de conocer a Jess y a sus hermanos.Sin dejar de abordar algunos hechos del pueblo Judo, que ocurrieron unos 300 aos aproximadamente antes de esta llegada, el relato bsicamente est centrado en algo desconocido para todos, la niez y adolescencia de Jesucristo con quien los hijos de Zebedeo convivieron.Trascurri mucho tiempo de que el herechi como asi le llamaba a Jess se haba marchado sin despedirse de Jerusaln. Un da tuvo conocimiento de que en las ciudades cercanas caminaba un hombre que se deca Hijo de Dios El Altsimo, que enseaba a todos los que entusiasmados le seguan, que sanaba a los enfermos, hacia mirar de nuevo a los ciegos incluso a los que haban nacido con tal impedimento, adems lograba que los cojos caminaran y aun mas levantaba de los sepulcros a los muertos. Todo ello, para muchos constitua actos sorprendentes y esa era la razn por la cual aumentaban sus seguidores. Shmuel, al escuchar estos comentarios tuvo la certeza de que se podra tratar de un amigo de el y de sus hermanos desde la poca de la niez y con quien desde hacan aos el deseaba tener un encuentro para formularle algunos reclamos en los cuales estaba involucrada su ahora esposa. Despus de seguirlo por muchos das al fin pudo verlo fue de lejos. Sin embargo, la multitud no permita que se diera el encuentro pese a que ya en esos das sus hermanos que ya se haban convertido en sus discpulos, y a quienes no les confes el verdadero motivo de su llegada, le haban saludado y le haban prometido apoyarlo en su objetivo. A los pocos das, al fin pudo estar frente a el, y Jess al verlo exclamo. Shammy, (a Shamuel, Jess tambin como a muchos les nombraba por otro nombre), desde hace das te veo con alegra entre la gente, semanas hace que te vi entre el grupose los motivos que te tienen aqu y creme que yo no poda hacer nada para acelerar nuestro encuentro ya que todo lo que se hace no est sujeto a la disposicin del hombre, sino a la disposicin y voluntad del tiempo de mi Padre.

No one whose opinion deserves a moment''s consideration can doubt that most of the great positive evils of the world are in themselves removable, and will, if human affairs continue to improve, be in the end reduced to narrow limits. J. S. Mill, Utilitarianism, II, 1863 Mill was not writing about herpesviruses, but had he known them as we do, he would have included them among the great positive evils of the world. They cause disease and premature death, and are very costly to our society. There is no loftier aim than to cure or prevent human infections with these viruses. The objective of much of the current research on herpesviruses is directed toward an understanding of the molecular mechanisms involved in initiation of infection, establish­ ment and termination of latent state, virus multiplication, and the destruction of cells which ultimately is the basis of the diseases caused by these viruses. At no time during the past 80 years, since members of the herpesvirus family were first discovered, has there been so much progress in our understanding of the biology of these viruses as in the past few years. Along with the development of a greater understanding of the molecular biol­ ogy of the well-known herpesviruses we have witnessed the isolation of new human herpes­ viruses.

No one whose opinion deserves a moment's consideration can doubt that most of the great positive evils of the world are in themselves removable, and will, if human affairs continue to improve, be in the end reduced to narrow limits. J. S. Mill, Utilitarianism, II, 1863 Mill was not writing about herpesviruses, but had he known them as we do, he would have included them among the great positive evils of the world. They cause disease and premature death, and are very costly to our society. There is no loftier aim than to cure or prevent human infections with these viruses. The objective of much of the current research on herpesviruses is directed toward an understanding of the molecular mechanisms involved in initiation of infection, establish­ ment and termination of latent state, virus multiplication, and the destruction of cells which ultimately is the basis of the diseases caused by these viruses. At no time during the past 80 years, since members of the herpesvirus family were first discovered, has there been so much progress in our understanding of the biology of these viruses as in the past few years. Along with the development of a greater understanding of the molecular biol­ ogy of the well-known herpesviruses we have witnessed the isolation of new human herpes­ viruses.

No todo es amor.Las cosas pasan por el tremor de la carne. Otro teje sus sueños en noches de insomnes. Yo tomo el cáliz amargo, ofrenda extraviada en infinitos nombres. Abro mi piel y no te hallo, sólo rumores de sangre, ecos ausentes.