Charles R. Cantor - Böcker

A unique exploration of the principles and methods underlying the Human Genome Project and modern molecular genetics and biotechnology-from two top researchersIn Genomics, Charles R. Cantor, former director of the Human Genome Project, and Cassandra L. Smith give the first integral overview of the strategies and technologies behind the Human Genome Project and the field of molecular genetics and biotechnology. Written with a range of readers in mind-from chemists and biologists to computer scientists and engineers-the book begins with a review of the basic properties of DNA and the chromosomes that package it in cells. The authors describe the three main techniques used in DNA analysis-hybridization, polymerase chain reaction, and electrophoresis-and present a complete exploration of DNA mapping in its many different forms. By explaining both the theoretical principles and practical foundations of modern molecular genetics to a wide audience, the book brings the scientific community closer to the ultimate goal of understanding the biological function of DNA. Genomics features:* Topical organization within chapters for easy reference* A discussion of the developing methods of sequencing, such as sequencing by hybridization (SBH) in which data is read through words instead of letters* Detailed explanations and critical evaluations of the many different types of DNA maps that can be generated-including cytogenic and restriction maps as well as interspecies cell hybrids* Informed predictions for the future of DNA sequencing

The aim of the Conference and its proceedings is to provide a forum in which experts from both the academic and the industrial sectors as well as other interested individuals (young researchers and students) can gain a first hand knowledge of the scope, direction and future prospects in the international initiation of human genome research and its supporting technologies of electrophoresis and computing.

Since the beginning of the genome project, the necessary involvement of scientists of widely divergent backgrounds has been evident. The proper handling, analysis, dissemination of information, and the control and data gathering of automated process are areas where computers are directly involved. Thus computers are intimately tied into the production and analysis of biological data. However, many challenges lie ahead.This volume is a collection of selected oral and poster presentations given at The Second International Conference on Bioinformatics, Supercomputing and Complex Genome Analysis, organized to address some of these challenges. The topics include the current status and future prospects of genome map, mapping and sequencing, complex genome analysis,linguistic and neural network approaches, database issues, and computer tools in the genome project. The volume will be ideal for students, newcomers, young researchers and experts alike, who are computationally or experimentally oriented.Keynote Speakers: C L Smith, D Grothues, T Ito, T Sano, D Wang, Y-W Zhu, C R Canton & R J Rohins.