Christopher A. Shaw – författare

This book provides a broad survey of many of the major areas in neuroplasticity research by leading investigators in the field. The topics considered range across all levels of nervous system organization from the molecular to behavioral levels for species ranging from C. elegans to humans. In addition, the effects of development and neuropathological events are discussed. A final summary chapter synthesizes the data gathered in this volume in order to provide the basis for a general theory of neuroplasticity.

The emerging understanding of age-related neurological disorders suggests that notions of a single causal gene/toxin being responsible is likely incorrect. Neurological disorders probably arise due to a unique intersection of multiple genetic and toxic factors, combined with additional contributions of age, stage of development, immune system actions, and more. This perspective leads to the view that rather than reflecting only one pathway to end-state disease, each is a spectrum disorder, and every individual case is therefore unique.Neural Dynamics of Neurological Disease argues for a fundamental rethinking of what we think we know about neurological disorders, how they arise and progress, and, crucially, what might be done to "cure" them. It first introduces the concept of neural dynamics of neurological disease, then examines various diseases and gives examples of the interplay of elements such as neural systems, cell types, and biochemical pathways that can contribute to disease. The concluding chapters point the way to how the emerging notion of neurological disease as a dynamic process may lead to more successful treatment options. Providing a cross-disciplinary approach to understanding the origin and progression of neurological disease, Neural Dynamics of Neurological Disease is a timely and valuable resource for neuroscientists, researchers, and clinicians.

SPECTRUMS OF AMYOTROPHIC LATERAL SCLEROSIS Discover state-of-the-art research findings on ALS from leading authors and editors in the fieldIn Spectrums of Amyotrophic Lateral Sclerosis: Heterogeneity, Pathogenesis & Therapeutic Directions, distinguished researchers and editors Dr. Christopher A. Shaw and Jessica R. Morrice deliver a practical and powerful perspective on Amyotrophic Lateral Sclerosis (ALS) as a heterogeneous spectrum of disorders. This increasingly accepted point-of-view allows researchers and medical professionals to develop better targeted interventions and more precise therapies.In the book, readers will find chapters on a wide variety of critical issues facing ALS researchers and healthcare practitioners treating ALS sufferers, including animal models of ALS, neuronal support cells known to have a pivotal role in ALS, and current challenges in ALS clinical trials, among others. The authors describe pathologic features common to all cases of ALS and why animal models, though crucial, should be interpreted with caution. Finally, multiple genetic and environmental etiologies of the disease are discussed.Readers will also benefit from the inclusion of:A thorough introduction to ALS as a spectrum disease and the implications for models, therapeutic development and clinical trial designExplorations of the genetic basis of ALS, prospective sALS etiologies, and the involvement of microbiome in ALSDiscussions of ALS-PDC and environmental risk factors, protein aggregation in ALS, defects in RNA metabolism in ALS, and the non-cell autonomous nature of ALS and the involvement of glial cellsExaminations of animal models of ALS and perspectives on previously failed ALS therapeutics and current therapeutic strategiesPerfect for clinical neurologists, healthcare providers and caretakers, clinicians, and researchers studying motor neuron disease, Spectrums of Amyotrophic Lateral Sclerosis: Heterogeneity, Pathogenesis & Therapeutic Directions is also an indispensable resource for the neurodegenerative research community, neurology residents, and graduate-level neuroscience students.

The consummate guide to the ultimate sabertooth.Few animals spark the imagination as much as the sabertooth cat Smilodon. With their incredibly long canines, which hung like fangs past their jaws, these ferocious predators were first encountered by humans when our species entered the Americas. We can only imagine what ice age humans felt when they were confronted by a wild cat larger than a Siberian tiger.Because Smilodon skeletons are perennial favorites with museum visitors, researchers have devoted themselves to learning as much as possible about the lives of these massive cats. This volume, edited by celebrated academics, brings together a team of experts to provide a comprehensive and contemporary view of all that is known about Smilodon. The result is a detailed scientific work that will be invaluable to paleontologists, mammalogists, and serious amateur sabertooth devotees. The book • covers all major aspects of the animal's natural history, evolution, phylogenetic relationships, anatomy, biomechanics, and ecology • traces all three Smilodon species across both North and South America• brings together original, unpublished research with historical accounts of Smilodon's discovery in nineteenth-century BrazilThe definitive reference on these iconic Pleistocene mammals, Smilodon will be cited by researchers for decades to come. Contributors: John P. Babiarz, Wendy J. Binder, Charles S. Churcher, Larisa R. G. DeSantis, Robert S. Feranec, Therese Flink, James L. Knight , Margaret E. Lewis, Larry D. Martin, H. Gregory McDonald, Julie A. Meachen, William C. H. Parr, Ashley R. Reynolds. Kevin L. Seymour, Christopher A. Shaw, C. S. Ware, Lars Werdelin, H. Todd Wheeler, Stephen Wroe, M. Aleksander Wysocki

A detailed examination of the COVID-19 pandemic.Down the COVID-19 Rabbit Hole discusses the widespread misuse of science during the pandemic, the likely origin of COVID-19, the pathophysiology of the disease itself, and the harms associated with the various vaccines that have been produced, particularly those based on the novel mRNA platforms. This book also looks at the widespread failure of the health professions to adequately understand and treat the disease and the consequences of the vaccines, the apparently agenda-driven responses of various governments, and the inability of the legal system to understand the implications for natural and civil rights. As well, Down the COVID-19 Rabbit Hole considers how most of the mainstream media largely became a propaganda tool for reigning governments.The official response to the pandemic has fractured society in ways that most people could not have imagined prior to 2020. Down the COVID-19 Rabbit Hole details these consequences, offers solutions to repair the damages to society, and considers ways to heal those damaged by the experimental vaccines.