Clare Hawkins – författare
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3 produkter
3 produkter
1 981 kr
Skickas inom 10-15 vardagar
Mammalian heme peroxidase enzymes play a critical role in innate immune responses and disease prevention. The formation of potent chemical oxidants is essential to this protective physiologic activity in immunity. Although highly beneficial in the context of immune defense, it is now well established that peroxidases and their overproduction of oxidants contribute to the initiation and persistence of many chronic inflammatory conditions in the cardiovascular, neurologic, respiratory, renal, and gastrointestinal systems. Peroxidasins, a protein family related to heme peroxidases, play a novel role in tissue biogenesis and matrix assembly, which are also attracting attention in different pathological contexts. Given the diverse roles of mammalian heme peroxidases and the breadth and incidence of pathologies associated with these enzymes, there has been significant interest in modulating peroxidase activity as a therapeutic strategy. This book highlights recent developments in our understanding of the chemistry, biochemistry and biological roles of mammalian peroxidases and their associated oxidants, their involvement in both innate immunity and chronic inflammatory disease in a variety of end organs, and potential therapeutic approaches to modulate and prevent damaging reactions.Key Features Structure and biosynthesis of mammalian peroxidases Reactivity of hypohalous acids with biological substrates Peroxidases in innate immunity Peroxidases in human pathologyModulation of peroxidase-induced biological damage
712 kr
Skickas inom 10-15 vardagar
Mammalian heme peroxidase enzymes play a critical role in innate immune responses and disease prevention. The formation of potent chemical oxidants is essential to this protective physiologic activity in immunity. Although highly beneficial in the context of immune defense, it is now well established that peroxidases and their overproduction of oxidants contribute to the initiation and persistence of many chronic inflammatory conditions in the cardiovascular, neurologic, respiratory, renal, and gastrointestinal systems. Peroxidasins, a protein family related to heme peroxidases, play a novel role in tissue biogenesis and matrix assembly, which are also attracting attention in different pathological contexts. Given the diverse roles of mammalian heme peroxidases and the breadth and incidence of pathologies associated with these enzymes, there has been significant interest in modulating peroxidase activity as a therapeutic strategy. This book highlights recent developments in our understanding of the chemistry, biochemistry and biological roles of mammalian peroxidases and their associated oxidants, their involvement in both innate immunity and chronic inflammatory disease in a variety of end organs, and potential therapeutic approaches to modulate and prevent damaging reactions.Key Features Structure and biosynthesis of mammalian peroxidases Reactivity of hypohalous acids with biological substrates Peroxidases in innate immunity Peroxidases in human pathologyModulation of peroxidase-induced biological damage
141 kr
Skickas
Frank Nixon, a raw 19-year-old army private, finds himself serving in Malta in 1940, which is about to endure the most prolonged and destructive assaults of its colourful and violent history. Soon aerial bombardments batter the small island and the defenders struggle to withstand the increasingly relentless attacks. Despite the dangers of life on the besieged island, Frank becomes fascinated by its history as a tiny strategic territory, for centuries at the mercy of powerful warmongers. In the midst of the horrors and privations, Frank discovers both his vulnerabilities and his strengths, through the pain and pleasure of his love for a local widow and the increasing demands of his duties. As the siege becomes more brutal, the island population, threatened with the prospect of starvation or surrender, have their courage and resilience tested to the extreme as they await relief in the war-torn Mediterranean. The Dust of Melita is a captivating historical fiction novel that takes readers on a journey through the turbulent history of Malta during World War Two, briefly interwoven with harrowing scenes from previous centuries and the lives of other ordinary people caught up in war and conflict.