Costas Demetzos – författare

Nanomaterials in Clinical Medicine: Case Studies in Nanomedicines focuses on the nanomaterials that can be formulated as drug delivery vehicles, such as liposomes, micelles, nanoemulsions and nanogels. Their physicochemical, morphological, thermo-dynamical and nanotoxicological properties are analyzed with respect to the design and development of drug delivery nanosystems for the encapsulation of an active pharmaceutical ingredient and its controlled release. Each chapter covers basic properties, the nanosystem (e.g., liposomes), the added value in drug delivery and targeting, and future perspectives. Case studies and examples of how nanomaterials are being used in clinical medicine, including marketed liposomal medicines and medical utility and regimens are also included.

Particular attention is given to new nanocarriers, such as elastic liposomes, lipid polymeric hybrid nanoparticles, organogel, nanofibers carbon nanomaterials, quantum dots and inorganic nanoparticles. This book is an important information source for those wanting to increase their understanding of what major nanomaterials are being used to create more effective drug delivery systems.

From Current to Future Trends in Pharmaceutical Technology explores the current trends of this field and creates a multi-aspect framework for the reader. The book covers topics on pharmaceutics, pharmaceutical engineering, pre-formulation protocols, techniques, innovative excipients, bio-printing techniques, scale-up based on formulas on-a-chip, and regulatory aspects based on new scientific achievements. Modified dosage forms, new aspects on the compatibility of drug excipients interactions, and drug release by various dosage forms are included. Physical pharmacy (physical and biological stability of dosage forms), innovative excipients, patents on innovative formulations and regulatory issues related to the approval process of medicines are also discussed.

The book is a valuable resource for a wide audience of academics, industrial researchers and professionals working in this field as the development of efficient and safe medicines is critical to future needs.

Nanotechnology seeks to exploit distinct technological advances controlling the structure of nanoscale biomaterials at a nanodimensional scale approaching individual molecules and their aggregates or supramolecular structures. The term "nanomedicine" is used to describe those technologies under the umbrella of nanotechnology that have therapeutic applications in human health. This book presents recent trends and research achievements in the field of pharmaceutical nanotechnology and advanced drug delivery nanosystems, especially for theranostic purposes. The applications of drug delivery nanosystems considered carriers of active pharmaceutical ingredients (APIs) (e.g., proteins, peptides, and nucleic acids) are analyzed on the basis of technology, preparation protocols, and biomedical applications. The book also extensively reports on the principles, design protocols, and applications of nanosystems in drug delivery, imaging, and targeting of active molecules of pharmaceutical interest.

Nanotechnology seeks to exploit distinct technological advances controlling the structure of nanoscale biomaterials at a nanodimensional scale approaching individual molecules and their aggregates or supramolecular structures. The term "nanomedicine" is used to describe those technologies under the umbrella of nanotechnology that have therapeutic applications in human health. This book presents recent trends and research achievements in the field of pharmaceutical nanotechnology and advanced drug delivery nanosystems, especially for theranostic purposes. The applications of drug delivery nanosystems considered carriers of active pharmaceutical ingredients (APIs) (e.g., proteins, peptides, and nucleic acids) are analyzed on the basis of technology, preparation protocols, and biomedical applications. The book also extensively reports on the principles, design protocols, and applications of nanosystems in drug delivery, imaging, and targeting of active molecules of pharmaceutical interest.

This book presents modern trends that regard the utilization of advanced functional materials for the development of innovative pharmaceuticals. Such materials include classes of lipids, polymers, proteins, and peptides, as well as inorganic materials, which find application in nanomedicinal products, drug delivery systems, medical devices, biotechnological products, and several other technologies. These products are promising for the therapy and diagnosis of diseases. Special attention is given to the available analytical techniques utilized for the evaluation of materials, their interactions, and their properties as well as the functionality of the final pharmaceutical forms. In addition, scale-up opportunities and limitations of nanomaterials and the current and emerging challenges in their clinical translation, with reference to relative regulatory aspects, are discussed. The book covers the latest advances in functional materials for biomedical applications and will serve as a guide for the industry and aid future research. It will be useful for upper undergraduate students and graduate students, young researchers (in the fields of pharmaceutics and materials sciences), scientists who want to enrich their knowledge on advanced drug delivery nanocarriers and their applications, researchers in the Big Pharma and readers who want to learn more about the role of nanoscience in the design and development of nanomedicines.

This book presents modern trends that regard the utilization of advanced functional materials for the development of innovative pharmaceuticals. Such materials include classes of lipids, polymers, proteins, and peptides, as well as inorganic materials, which find application in nanomedicinal products, drug delivery systems, medical devices, biotechnological products, and several other technologies. These products are promising for the therapy and diagnosis of diseases. Special attention is given to the available analytical techniques utilized for the evaluation of materials, their interactions, and their properties as well as the functionality of the final pharmaceutical forms. In addition, scale-up opportunities and limitations of nanomaterials and the current and emerging challenges in their clinical translation, with reference to relative regulatory aspects, are discussed. The book covers the latest advances in functional materials for biomedical applications and will serve as a guide for the industry and aid future research. It will be useful for upper undergraduate students and graduate students, young researchers (in the fields of pharmaceutics and materials sciences), scientists who want to enrich their knowledge on advanced drug delivery nanocarriers and their applications, researchers in the Big Pharma and readers who want to learn more about the role of nanoscience in the design and development of nanomedicines.

Nanotechnology in Therapeutics

Comprehensive reference delivering a framework to develop and assess nanosystems that provide unique advantages in biomedical applications

Nanotechnology in Therapeutics explores the idea that by studying in depth the behavior of living organisms, especially the functionality of their cell membranes, we can develop and evaluate innovative bio-inspired nanosystems that are able to deliver small molecules, biomolecules like proteins, peptides, and other genetic material in terms of the production of new therapies and vaccines. The main concept promoted in this book is an integrated approach for producing new medicines following the nanotoxicity, biotoxicity, regulatory, and ethical guidelines, which are also covered in the book.

The book is divided into three parts. Part A provides an introduction and a historical overview of nanotechnology. Part B delves deeper into issues relating to lipid and polymeric nanostructures in medicine. Part C presents the regulatory landscape around nanotechnology and nanomedicine, while highlighting the need to keep an eye on emerging technologies such as artificial intelligence and machine learning. Overall, this book opens up biomedical applications for previously challenging drugs and drug targets.

Written by a highly qualified professor with significant pertinent research experience, Nanotechnology in Therapeutics includes discussion on:

With comprehensive coverage of novel concepts that have the potential to transform how new medicines are designed and developed, Nanotechnology in Therapeutics is an essential resource on the subject for chemists in industry, as well as biomedical and pharmaceutical engineers.

Nanotechnology in Therapeutics

Comprehensive reference delivering a framework to develop and assess nanosystems that provide unique advantages in biomedical applications

Nanotechnology in Therapeutics explores the idea that by studying in depth the behavior of living organisms, especially the functionality of their cell membranes, we can develop and evaluate innovative bio-inspired nanosystems that are able to deliver small molecules, biomolecules like proteins, peptides, and other genetic material in terms of the production of new therapies and vaccines. The main concept promoted in this book is an integrated approach for producing new medicines following the nanotoxicity, biotoxicity, regulatory, and ethical guidelines, which are also covered in the book.

The book is divided into three parts. Part A provides an introduction and a historical overview of nanotechnology. Part B delves deeper into issues relating to lipid and polymeric nanostructures in medicine. Part C presents the regulatory landscape around nanotechnology and nanomedicine, while highlighting the need to keep an eye on emerging technologies such as artificial intelligence and machine learning. Overall, this book opens up biomedical applications for previously challenging drugs and drug targets.

Written by a highly qualified professor with significant pertinent research experience, Nanotechnology in Therapeutics includes discussion on:

With comprehensive coverage of novel concepts that have the potential to transform how new medicines are designed and developed, Nanotechnology in Therapeutics is an essential resource on the subject for chemists in industry, as well as biomedical and pharmaceutical engineers.

This book highlights the recent advances of thermodynamics and biophysics in drug delivery nanosystems and in biomedical nanodevices. The up-to-date book provides an in-depth knowledge of bio-inspired nanotechnological systems for pharmaceutical applications.

Biophysics and thermodynamics, supported by mathematics, are the locomotive by which the drug transportation and the targeting processes will be achieved under the light of the modern pharmacotherapy. They are considered as scientific tools that promote the understanding of physicochemical and thermotropic functionality and behavior of artificial cell membranes and structures like nanoparticulate systems. Therefore, this book focusses on new aspects of biophysics and thermodynamics as important elements for evaluating biomedical nanosystems, and it correlates their physicochemical, biophysical and thermodynamical behaviour with those of a living organism.

In 2018, Prof. Demetzos was honored with an award by the Order of Sciences of the Academy of Athens for his scientific contribution in Pharmaceutical Nanotechnology.