Daniel Best – författare

Enediynes are natural products with highly active cytotoxicity and antibacterial activity, and thus have significant potential in the development of anti-cancer treatments. However, they are not readily available and can degrade rapidly during isolation; one solution is to produce them using total synthesis.Dynemicin A and uncialamycin are two such enediynes, with similar structures, for which total synthesis has been achieved. This book presents the isolation and preparation of these two compounds and their analogues through various synthesis strategies. Details of the structural elements essential to their anti-cancer activity are presented, with the objective of explaining and optimizing their biological activities and potential development as drugs.- Presents two natural ènediynes with similar structures whose total syntheses have been accomplished- Explores structural analogs of preparation for purposes of optimizing the anti-cancer activity- Describes the total syntheses of dynemicin A, the uncialamycine, as well as analogs by emphasizing the synthesis strategies adopted- Features studies of the biological activities and data to bring out the structural elements of these essential compounds

In 1948, the Australian government banned the production, importation and exhibition of horror films in a move to appease religious communities and entertainment watchdogs. Drawing upon previously unseen government documents, private letters and contemporary newspaper accounts, this book is the first to extensively cover the history of censorship and the early production of horror movies in Australia. Beginning its examination in the late 19th century, the book documents the earliest horror films like Georges Melies' The Haunted Castle (1896), and how Australians enjoyed such films before the ban. The book then explains how certain imports, like 1954's Creature from the Black Lagoon, were able to circumvent the ban while others were not. It also reveals how Australian television, though similarly impacted by government censorship, was occasionally able to broadcast films technically banned from cinematic release. The work concludes with a look at the first Australian horror films produced after the ban was formally lifted in 1969, like Terry Bourke's Night of Fear (1973).

Enediynes are natural products with highly active cytotoxicity and antibacterial activity, and thus have significant potential in the development of anti-cancer treatments. However, they are not readily available and can degrade rapidly during isolation; one solution is to produce them using total synthesis.Dynemicin A and uncialamycin are two such enediynes, with similar structures, for which total synthesis has been achieved. This book presents the isolation and preparation of these two compounds and their analogues through various synthesis strategies. Details of the structural elements essential to their anti-cancer activity are presented, with the objective of explaining and optimizing their biological activities and potential development as drugs.

Presents two natural �nediynes with similar structures whose total syntheses have been accomplished Explores structural analogs of preparation for purposes of optimizing the anti-cancer activity Describes the total syntheses of dynemicin A, the uncialamycine, as well as analogs by emphasizing the synthesis strategies adopted Features studies of the biological activities and data to bring out the structural elements of these essential compounds