David A. Wells – författare

High Throughput Bioanalytical Sample Preparation: Methods and Automation Strategies is an authoritative reference on the current state-of-the-art in sample preparation techniques for bioanalysis. This book focuses on high throughput (rapid productivity) techniques and describes exactly how to perform and automate these methodologies, including useful strategies for method development and optimization. A thorough review of the literature is included within each of these chapters describing high throughput sample preparation techniques: protein removal by precipitation; equilibrium dialysis and ultrafiltration; liquid-liquid extraction; solid-phase extraction; and various on-line techniques.The text begins with an introductory overview of the role of bioanalysis in pharmaceutical drug development. Fundamental understanding of the strategies for sample preparation is reinforced next, along with essential concepts in extraction chemistry. Several chapters introduce and discuss microplates, accessory products and automation devices. Particular strategies for efficient use of automation within a bioanalytical laboratory are also presented. The subject material then reviews protein precipitation, liquid-liquid extraction, solid-phase extraction and various on-line sample preparation approaches. The book concludes with information on recent advances in sample preparation, such as solid-phase extraction in a card format and higher density extraction plates.Important objectives that can be accomplished when the strategies presented in this book are followed include: improved efficiency in moving discovery compounds to preclinical status with robust analytical methods; return on investment in automation for sample preparation; and improved knowledge and expertise of laboratory staff.�Shows the reader exactly how to perform modern bioanalytical sample preparation techniques, complete with detailed strategies�Thorough literature review and summary of published information�Detailed discussion and examples of the method development process

David Ames Wells (1828-1898), a prominent American financial economist, political activist and apostle of laissez faire, was a staunch advocate of free trade and the abolition of the tariff. "e;Wells wrote a large number of books, pamphlets, and articles ... His chief interests were the tariff, the theory of money and the currency question, and taxation. His discussion of all of these took character from his inspection of American economic life, which was marked in his period by progressive lowering of costs of production through the application of science. He, more than others, was the expositor of the nature and consequences of the 'machine age' Some of his most effective writing was in opposition to fiat money or depreciated monetary standards. An excellent example of his work in this field is his "e;ROBINSON CRUSOE'S MONEY"e;, issued first in 1876 when resumption was in doubt, and again in 1896 when the 'free silver' advocacy was in full swing. Wells was among the earliest to appreciate the importance of what has since been known as 'technological unemployment,' the displacing of men by machines