David G. I. Scott – författare

Rheumatic disease is a major cause of morbidity and disability in the Western world. There have been major developments in our understanding of the causes of rheumatic disease and in their treatment during the last half-century, and there are relatively few papers which can be regarded as truly ''landmark'' in their construction and subsequent findings. Part of the Landmark Papers in series, this book provides a detailed review of the seminal papers that have paved the way for breakthroughs in the clinical management of the entire spectrum of rheumatic diseases.

Rheumatic disease is a major cause of morbidity and disability in the Western world. There have been major developments in our understanding of the causes of rheumatic disease and in their treatment during the last half-century, and there are relatively few papers which can be regarded as truly ''landmark'' in their construction and subsequent findings. Part of the Landmark Papers in series, this book provides a detailed review of the seminal papers that have paved the way for breakthroughs in the clinical management of the entire spectrum of rheumatic diseases.

Rheumatic disease is a major cause of morbidity and disability in the Western world. There have been major developments in our understanding of the causes of rheumatic disease and in their treatment during the last half-century, and there are relatively few papers which can be regarded as truly 'landmark' in their construction and subsequent findings. Part of the Landmark Papers in series, this book provides a detailed review of the seminal papers that have paved the way for breakthroughs in the clinical management of the entire spectrum of rheumatic diseases.

The systemic vasculitides are a group of disorders which are of increasing importance. Many of these conditions are only rarely encountered by general physicians and often present significant diagnostic challenges. Our goal in writing this short book was to provide easily accessible information in a pocket-sized format. We hope we have helped both the g- eral rheumatologist who only encounter these problems occasionally. We have focused on clinical presentation, di- nostic processes, and current management. We hope, the- fore, that we will help our patients with these potentially devastating conditions by improving diagnosis and therapy. Richard A. Watts Ipswich, UK David G. I. Scott Norwich, UK v Contents Part I Introduction 1 Defnitions 3 1 1 General Introduction 3 1 2 Defnitions 4 2 Classifcation and Epidemiology 7 2 1 Introduction 7 2 2 ACR (1990) Criteria 8 2 3 Chapel Hill Consensus Defnitions 9 2 4 Epidemiology 9 2 5 Etiological Factors 10 References 11 3 General Presentation of the Vasculitides 13 3 1 Introduction 13 3 2 Pattern Recognition 13 3 3 Laboratory Investigations 16 3 4 Differential Diagnosis 18 References 19 4 General Principles of Treatment 21 4 1 Treatment 21 4 2 Remission Induction 21 4. 2. 1 Large Vessel Disease . . . . . . . . . . . . . . 22 4. 2. 2 Medium Vessel Disease . . . . . . . . . . . . 22 4. 2. 3 Medium/Small Vessel Vasculitis . . . . . 22 4. 2. 4 Small Vessel Vasculitis . . . . . . . . . . . . .

This book focuses on clinical presentation, diagnostic processes and current management of systematic vasculitis, and for this second edition the Editors have updated the treatment approach and nomenclature in line with current practice. Systemic vasculitides are a group of disorders which are of increasing importance. Many of these conditions are only rarely encountered by general physicians and often present significant diagnostic challenges. The Editors aim to provide easily accessible information in a pocket sized format. In doing so they hope to help both the generalist but also rheumatologists who only encounter these problems occasionally.