David Graves – författare

This book explores Wittgenstein’s unsettling remark in the Tractatus that the only necessity that exists is logical necessity. It suggests that the notion of necessity is a primitive notion, and, as such, both a requirement for human cognition and constitutive of rational thought.On this basis, the book then reexamines some of the perennial questions of philosophy including logic itself, beauty, law, truth and the concept of God. All of these topics are seen to be closely related to the notion of necessity. It is argued that if logical necessity is the only necessity that exists, then Kant’s notion of the subjective necessity of aesthetic judgments must be reconsidered. Likewise, metaphysical, moral, and practical necessity must all be revised.Finally, a new dimension is added to the analysis. It is shown that the notion of logical necessity is human in its origin, and yet also absolute. This insight reopens the possibility of logical absolutism, as opposed to the current, general consensus around logical relativism. Moreover, it becomes possible to entertain a notion of logical absolutism without the problematic baggage of metaphysical and/or divine considerations. This new sense of logical absolutism facilitates a reconsideration of certain epistemological claims directly related to logical truths, for example, so-called analytical propositions.Logical Necessity and Rational Thought is essential reading for all scholars, researchers and advanced students of philosophical logic. It is also ideal for researchers of the thought of Ludwig Wittgenstein.

Offers insights into the Small Molecule Targeting of the G-Quadruplex in the c-MYC Promoter Using NMR and an Allele-Specific Transcriptional Assay.

Gaining Insights into the Small Molecule Targeting of the G-Quadruplex in the c-MYC Promoter Using NMR and an Allele-Specific Transcriptional Assay, by Christine E. Kaiser, Vijay Gokhale, Danzhou Yang and Laurence H. Hurley.- Higher-Order Quadruplex Structures, by Luigi Petraccone.- Investigation of Quadruplex Structure Under Physiological Conditions Using In-Cell NMR, by Robert Hänsel, Silvie Foldynová-Trantírková, Volker Dötsch and Lukás Trantírek.- Circular Dichroism of Quadruplex Structures, by Antonio Randazzo, Gian Piero Spada and Mateus Webba da Silva.- Molecular Crowding and Hydration Regulating of G-Quadruplex Formation, by Daisuke Miyoshi, Takeshi Fujimoto and Naoki Sugimoto.- Visualizing the Quadruplex: From Fluorescent Ligands to Light-Up Probes, by Eric Largy, Anton Granzhan, Florian Hamon, Daniela Verga and Marie-Paule Teulade-Fichou.- Calculation of Hydrodynamic Properties for G-Quadruplex Nucleic Acid Structures from in silico Bead Models, by Huy T. Le, Robert Buscaglia, William L. Dean, Jonathan B. Chaires and John O. Trent.- Energetics of Ligand Binding to G-Quadruplexes, Concetta Giancola and Bruno Pagano.- Tetramolecular Quadruplex Stability and Assembly, by Phong Lan Thao Tran, Anne De Cian, Julien Gros, Rui Moriyama and Jean-Louis Mergny.