David Kessel - Böcker

The use of porphyrins for localization and photodynamic therapy of neoplastic disease has been the topic of several international symposia, reviews and books during the preceeding five years. The literature on this topic has continued to grow, as have numbers of presentations at national and international meetings relating to photobiology, chemistry, and lasers. In this volume, it is the intention of the editor to provide both information on current research projects, and detailed methodology used in such investigations. A bibliography on the subjects of porphyrin localization and therapy is included. The manuscripts contained in this volume are based on reports given at a Porphyrin Photosensitization Workshop which was held in Philadel­ phia, July 6-7, 1984. This Workshop was supported by NIH grant CA 36746, together with funds from the Fogarty International Center. Authors were requested to update their contributions to provide a summary of progress to mid 1985. Manuscripts containing material not presented in Philadelphia are also included, notably a series of articles describ­ ing current clinical and pre-clinical results from China. Since the Philadelphia Workshop, a meeting was held in Alghero, Sardinia (May, 1985), and additional conferences are now being planned; this attests to the continued interest in photodynamic therapy involving porphyrin photo­ sensitization.

This book contains contributions from participants at a Porphyrin Photosensitization Workshop held in Washington DC on 28-29 September, 1981. There had been several prior such gatherings during 1979 and 1980, but the 1981 meeting was the most extensive to date with almost 200 attending. These periodic meetings are designed to enable workers in the field to exchange information and learn of recent develop- ments. The Workshop was supported by PHS grant CA 31188 awarded by the National Cancer Institute, DHHS. Additional funds from Coherent Inc. [Laser Division], Palo Alto, con- tributed to the success of this meeting as did the many ex- cellent presentations and discussions. Preparation of camera-ready copy from submitted manu- scripts was carried out via the Textedit computer program by Glenn Cummings, Amanda Cummings and David Kessel. Respon- sibility for final manuscript preparation rests with the editors. David Kessel Thomas J. Dougherty CONTENTS INTRODUCTION D. Kessel and T.J. Dougherty. . * * . * . * . * * 1 PHOTORADIATION THERAPY - CLINICAL AND DRUG ADVANCES 3 T.J. Dougherty, D.G. Boyle, K.R. Weishaupt, B.A. Henderson, W.R. Potter, D.A. Bellnier and K.E.Wityk INTRA-ABDOMINAL APPLICATIONS OF HEMATOPORPHYRIN 15 PHOTORADIATION THERAPY . * ...* . * * .

Lee and Watkinson's Techniques in Interventional Radiology series of handbooks describes in detail the various interventional radiology procedures and therapies that are in current practice. Forthcoming are volumes on pediatric interventional radiology and neurointerventional radiology.