David Mortimer – författare

This practical manual on sperm analysis presents the diagnostic and therapeutic procedures that are used in andrology laboratories to analyse and assess male infertility. Diagnostic areas include: semen analysis and the biochemical, immunological and microbiological examination of human semen and spermatozoa; computer-aided sperm motility analysis; sperm ultrastructure; and assessment of sperm transport through the female tract and sperm fertilizing ability. The clinical relevance of various diagnostic procedures is also discussed. Therapeutic topics include sperm washing techniques, semen cryopreservation, and insemination procedures. The volume also covers safety in the andrology laboratory, technician training, and quality control. The text is extensively illustrated and will be an invaluable resource to all scientists and technicians who diagnose male infertility. It will also be of interest to researchers working in human gamete biology and reproductive physiology. The detailed methods described in the book are relevant to all hospital, commercial, and university laboratories involved in infertility diagnosis and treatment.

This essential survival guide for successfully managing the modern-day IVF clinic condenses a wealth of expertise and experience from the authors in troubleshooting and implementing quality management in the IVF laboratory. With high-profile media coverage of mistakes at IVF clinics, and escalating regulatory scrutiny, there is increasing pressure for professional accreditation. Modern accreditation schemes, which are largely based on the principles of ISO 9001 and related standards, require Quality Systems. Yet quality management beyond basic assay quality control is often poorly understood by biomedical scientists outside clinical chemistry laboratories. Quality and risk management are thus becoming hot topics for those working in IVF clinics and this book brings together, for the first time in one place, the basics of these essential aspects of laboratory management. The focus on taking a holistic approach to ''prophylactic management'' - prevention rather than cure - will be welcomed by all scientists working in IVF.

This practical, extensively illustrated handbook covers the procedures that are undertaken in andrology and ART laboratories to analyse and assess male-factor infertility, and to prepare spermatozoa for use in assisted conception therapy. The content is presented as brief, authoritative overviews of the relevant biological background for each area, plus detailed, step-by-step descriptions of the relevant analytical procedures. Each technical section includes quality control considerations and the optimum presentation of results. In addition to the comprehensive 'basic' semen analysis, incorporating careful analysis of sperm morphology, the handbook provides established techniques for the use of computer-aided sperm analysis and sperm functional assessment. The interpretation of laboratory results in the clinical context is highlighted throughout, and safe laboratory practice is emphasized. Fully revised, incorporating the new ISO TS 23162 on basic human semen analysis throughout, this is an invaluable resource to all scientists and technicians who perform diagnostic testing for male-factor infertility.

This practical, extensively illustrated handbook covers the procedures that are undertaken in andrology and ART laboratories to analyse and assess male-factor infertility, and to prepare spermatozoa for use in assisted conception therapy. The content is presented as brief, authoritative overviews of the relevant biological background for each area, plus detailed, step-by-step descriptions of the relevant analytical procedures. Each technical section includes quality control considerations and the optimum presentation of results. In addition to the comprehensive ''basic'' semen analysis, incorporating careful analysis of sperm morphology, the handbook provides established techniques for the use of computer-aided sperm analysis and sperm functional assessment. The interpretation of laboratory results in the clinical context is highlighted throughout, and safe laboratory practice is emphasized. Fully revised, incorporating the new ISO TS 23162 on basic human semen analysis throughout, this is an invaluable resource to all scientists and technicians who perform diagnostic testing for male-factor infertility.

This practical, extensively illustrated handbook covers the procedures that are undertaken in andrology and ART laboratories to analyse and assess male-factor infertility, and to prepare spermatozoa for use in assisted conception therapy. The content is presented as brief, authoritative overviews of the relevant biological background for each area, plus detailed, step-by-step descriptions of the relevant analytical procedures. Each technical section includes quality control considerations and the optimum presentation of results. In addition to the comprehensive ''basic'' semen analysis, incorporating careful analysis of sperm morphology, the handbook provides established techniques for the use of computer-aided sperm analysis and sperm functional assessment. The interpretation of laboratory results in the clinical context is highlighted throughout, and safe laboratory practice is emphasized. Fully revised, incorporating the new ISO TS 23162 on basic human semen analysis throughout, this is an invaluable resource to all scientists and technicians who perform diagnostic testing for male-factor infertility.

Public concern over high-profile mistakes in IVF clinics and the concomitant increase in governmental regulation, have given rise to widespread recognition of the need for accreditation of IVF clinics. Modern accreditation schemes are largely based on the principles of ISO 9001 and related standards, at the heart of which lies the expectation of a formal quality management system. Risk analysis and risk minimization are also being demanded of IVF clinics, but many only have limited understanding of how to approach these essential management tasks. This book brings together the basics of quality management and risk management, focussing on 'prophylactic management' - prevention rather than cure. Each chapter in this new edition is fully updated and extended to include new material such as, quality and risk management in the ART clinic, and an illustrative example of a 'well-run' clinic. This is the essential guide for clinicians and IVF laboratory staff.

Male factor infertility is receiving greater emphasis in IVF programs. This book reviews the scientific evidence for various medical, environmental and lifestyle factors that can affect male fertility, such as chromosome abnormalities, age, anti-sperm antibodies and endocrine disruptors. Part of a four-book series on improving IVF success, this volume subsequently explores a range of treatments and strategies to improve sperm quality, including FSH treatment and antioxidants. It also discusses methods to prevent male infertility from childhood through to adulthood. Concise, practical and evidence-based - and with insights from global experts in the field - this text will enable gynecologists, urologists and andrologists to make evidence-based decisions that can influence the success rate of fertilization in subsequent IVF cycles.

Male factor infertility is receiving greater emphasis in IVF programs. This book reviews the scientific evidence for various medical, environmental and lifestyle factors that can affect male fertility, such as chromosome abnormalities, age, anti-sperm antibodies and endocrine disruptors. Part of a four-book series on improving IVF success, this volume subsequently explores a range of treatments and strategies to improve sperm quality, including FSH treatment and antioxidants. It also discusses methods to prevent male infertility from childhood through to adulthood. Concise, practical and evidence-based - and with insights from global experts in the field - this text will enable gynecologists, urologists and andrologists to make evidence-based decisions that can influence the success rate of fertilization in subsequent IVF cycles.

Male factor infertility is receiving greater emphasis in IVF programs. This book reviews the scientific evidence for various medical, environmental and lifestyle factors that can affect male fertility, such as chromosome abnormalities, age, anti-sperm antibodies and endocrine disruptors. Part of a four-book series on improving IVF success, this volume subsequently explores a range of treatments and strategies to improve sperm quality, including FSH treatment and antioxidants. It also discusses methods to prevent male infertility from childhood through to adulthood. Concise, practical and evidence-based - and with insights from global experts in the field - this text will enable gynecologists, urologists and andrologists to make evidence-based decisions that can influence the success rate of fertilization in subsequent IVF cycles.

Public concern over high-profile mistakes in IVF clinics and the concomitant increase in governmental regulation, have given rise to widespread recognition of the need for accreditation of IVF clinics. Modern accreditation schemes are largely based on the principles of ISO 9001 and related standards, at the heart of which lies the expectation of a formal quality management system. Risk analysis and risk minimization are also being demanded of IVF clinics, but many only have limited understanding of how to approach these essential management tasks. This book brings together the basics of quality management and risk management, focussing on ''prophylactic management'' - prevention rather than cure. Each chapter in this new edition is fully updated and extended to include new material such as, quality and risk management in the ART clinic, and an illustrative example of a ''well-run'' clinic. This is the essential guide for clinicians and IVF laboratory staff.

Public concern over high-profile mistakes in IVF clinics and the concomitant increase in governmental regulation, have given rise to widespread recognition of the need for accreditation of IVF clinics. Modern accreditation schemes are largely based on the principles of ISO 9001 and related standards, at the heart of which lies the expectation of a formal quality management system. Risk analysis and risk minimization are also being demanded of IVF clinics, but many only have limited understanding of how to approach these essential management tasks. This book brings together the basics of quality management and risk management, focussing on ''prophylactic management'' - prevention rather than cure. Each chapter in this new edition is fully updated and extended to include new material such as, quality and risk management in the ART clinic, and an illustrative example of a ''well-run'' clinic. This is the essential guide for clinicians and IVF laboratory staff.

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