Declan Bates – författare

Like engineering systems, biological systems must also operate effectively in the presence of internal and external uncertainty—such as genetic mutations or temperature changes, for example. It is not surprising, then, that evolution has resulted in the widespread use of feedback, and research in systems biology over the past decade has shown that feedback control systems are widely found in biology. As an increasing number of researchers in the life sciences become interested in control-theoretic ideas such as feedback, stability, noise and disturbance attenuation, and robustness, there is a need for a text that explains feedback control as it applies to biological systems.Written by established researchers in both control engineering and systems biology, Feedback Control in Systems Biology explains how feedback control concepts can be applied to systems biology. Filling the need for a text on control theory for systems biologists, it provides an overview of relevant ideas and methods from control engineering and illustrates their application to the analysis of biological systems with case studies in cellular and molecular biology. Control Theory for Systems BiologistsThe book focuses on the fundamental concepts used to analyze the effects of feedback in biological control systems, rather than the control system design methods that form the core of most control textbooks. In addition, the authors do not assume that readers are familiar with control theory. They focus on "control applications" such as metabolic and gene-regulatory networks rather than aircraft, robots, or engines, and on mathematical models derived from classical reaction kinetics rather than classical mechanics. Another significant feature of the book is that it discusses nonlinear systems, an understanding of which is crucial for systems biologists because of the highly nonlinear nature of

Like engineering systems, biological systems must also operate effectively in the presence of internal and external uncertainty-such as genetic mutations or temperature changes, for example. It is not surprising, then, that evolution has resulted in the widespread use of feedback, and research in systems biology over the past decade has shown that

Like engineering systems, biological systems must also operate effectively in the presence of internal and external uncertainty—such as genetic mutations or temperature changes, for example. It is not surprising, then, that evolution has resulted in the widespread use of feedback, and research in systems biology over the past decade has shown that feedback control systems are widely found in biology. As an increasing number of researchers in the life sciences become interested in control-theoretic ideas such as feedback, stability, noise and disturbance attenuation, and robustness, there is a need for a text that explains feedback control as it applies to biological systems.Written by established researchers in both control engineering and systems biology, Feedback Control in Systems Biology explains how feedback control concepts can be applied to systems biology. Filling the need for a text on control theory for systems biologists, it provides an overview of relevant ideas and methods from control engineering and illustrates their application to the analysis of biological systems with case studies in cellular and molecular biology. Control Theory for Systems BiologistsThe book focuses on the fundamental concepts used to analyze the effects of feedback in biological control systems, rather than the control system design methods that form the core of most control textbooks. In addition, the authors do not assume that readers are familiar with control theory. They focus on "control applications" such as metabolic and gene-regulatory networks rather than aircraft, robots, or engines, and on mathematical models derived from classical reaction kinetics rather than classical mechanics. Another significant feature of the book is that it discusses nonlinear systems, an understanding of which is crucial for systems biologists because of the highly nonlinear nature of

Like engineering systems, biological systems must also operate effectively in the presence of internal and external uncertainty-such as genetic mutations or temperature changes, for example. It is not surprising, then, that evolution has resulted in the widespread use of feedback, and research in systems biology over the past decade has shown that

Despite many signi?cant advances in the theory of nonlinear control in recent years, the majority of control laws implemented in the European aerospace - dustry are still designed and analysed using predominantly linear techniques applied to linearised models of the aircrafts’ dynamics. Given the continuous increase in the complexity of aircraft control laws, and the corresponding - crease in the demands on their performance and reliability, industrial control law designers are highly motivated to explore the applicability of new and more powerful methods for design and analysis. The successful application of fully nonlinear control techniques to aircraft control problems o?ers the prospect of improvements in several di?erent areas. Firstly, there is the possibility of - proving design and analysis criteria to more fully re?ect the nonlinear nature of the dynamics of the aircraft. Secondly, the time and e?ort required on the part of designers to meet demanding speci?cations on aircraft performance and h- dling could be reduced. Thirdly, nonlinear analysis techniques could potentially reduce the time and resources required to clear ?ight control laws, and help to bridge the gap between design, analysis and ?nal ?ight clearance. Theaboveconsiderationsmotivatedtheresearchpresentedinthisbook,which is the result of a three-year research e?ort organised by the Group for Aeron- tical Research and Technology in Europe (GARTEUR). In September 2004, GARTEUR Flight Mechanics Action Group 17 (FM-AG17) was established to conduct research on ”New Analysis and Synthesis Techniques for Aircraft Control”.

Despite many signi?cant advances in the theory of nonlinear control in recent years, the majority of control laws implemented in the European aerospace - dustry are still designed and analysed using predominantly linear techniques applied to linearised models of the aircrafts’ dynamics. Given the continuous increase in the complexity of aircraft control laws, and the corresponding - crease in the demands on their performance and reliability, industrial control law designers are highly motivated to explore the applicability of new and more powerful methods for design and analysis. The successful application of fully nonlinear control techniques to aircraft control problems o?ers the prospect of improvements in several di?erent areas. Firstly, there is the possibility of - proving design and analysis criteria to more fully re?ect the nonlinear nature of the dynamics of the aircraft. Secondly, the time and e?ort required on the part of designers to meet demanding speci?cations on aircraft performance and h- dling could be reduced. Thirdly, nonlinear analysis techniques could potentially reduce the time and resources required to clear ?ight control laws, and help to bridge the gap between design, analysis and ?nal ?ight clearance. Theaboveconsiderationsmotivatedtheresearchpresentedinthisbook,which is the result of a three-year research e?ort organised by the Group for Aeron- tical Research and Technology in Europe (GARTEUR). In September 2004, GARTEUR Flight Mechanics Action Group 17 (FM-AG17) was established to conduct research on ”New Analysis and Synthesis Techniques for Aircraft Control”.