Inbunden, Engelska, 2011
1 822 kr
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Dennis J Selkoe – författare
Visar alla böcker från författaren Dennis J Selkoe. Handla med fri frakt och snabb leverans.
8 produkter
8 produkter
- Inbunden, Engelska, 2008
1 702 kr
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During most of the 20th century, neurodegenerative diseases remained among the most enigmatic disorders of medicine. The scientific study of these conditions was descriptive in nature, detailing the clinical and neuropathological phenotypes associated with various diseases, but etiologies and pathogenic mechanisms remained obscure. Beginning in the 1970s, advances in two principal areas – biochemical pathology and molecular genetics – combined to yield powerful clues to the molecular underpinnings of several previously "idiopathic" brain disorders. Among the classical neurodegenerative diseases, perhaps the most rapid progress occurred in research on Alzheimer’s disease (AD). In disorders like Huntington’s disease, amyotrophic lateral sclerosis and even Parkinson’s disease, unbiased genetic screens, linkage analysis and positional cloning have identified causative genes that subsequently allowed the formulation of specific biochemical hypotheses. In sharp contrast, modern research on AD developed in the opposite order: the identification of the protein subunits of the classical brain lesions guided geneticists to disease-inducing genes, for example, APP, apolipoprotein E and tau. Thus, a biochemical hypothesis of disease - that AD is a progressive cerebral amyloidosis caused by the aggregation of the amyloid b-protein (Ab) - preceded and enabled the discovery of etiologies. - E-bokPDF, Engelska, 2008
2 127 kr
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During most of the 20th century, neurodegenerative diseases remained among the most enigmatic disorders of medicine. The scientific study of these conditions was descriptive in nature, detailing the clinical and neuropathological phenotypes associated with various diseases, but etiologies and pathogenic mechanisms remained obscure. Beginning in the 1970s, advances in two principal areas – biochemical pathology and molecular genetics – combined to yield powerful clues to the molecular underpinnings of several previously "idiopathic" brain disorders. Among the classical neurodegenerative diseases, perhaps the most rapid progress occurred in research on Alzheimer’s disease (AD). In disorders like Huntington’s disease, amyotrophic lateral sclerosis and even Parkinson’s disease, unbiased genetic screens, linkage analysis and positional cloning have identified causative genes that subsequently allowed the formulation of specific biochemical hypotheses. In sharp contrast, modern research on AD developed in the opposite order: the identification of the protein subunits of the classical brain lesions guided geneticists to disease-inducing genes, for example, APP, apolipoprotein E and tau. Thus, a biochemical hypothesis of disease - that AD is a progressive cerebral amyloidosis caused by the aggregation of the amyloid b-protein (Ab) - preceded and enabled the discovery of etiologies.
- Häftad, Engelska, 2010
1 702 kr
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During most of the 20th century, neurodegenerative diseases remained among the most enigmatic disorders of medicine. The scientific study of these conditions was descriptive in nature, detailing the clinical and neuropathological phenotypes associated with various diseases, but etiologies and pathogenic mechanisms remained obscure. Beginning in the 1970s, advances in two principal areas – biochemical pathology and molecular genetics – combined to yield powerful clues to the molecular underpinnings of several previously "idiopathic" brain disorders. Among the classical neurodegenerative diseases, perhaps the most rapid progress occurred in research on Alzheimer’s disease (AD). In disorders like Huntington’s disease, amyotrophic lateral sclerosis and even Parkinson’s disease, unbiased genetic screens, linkage analysis and positional cloning have identified causative genes that subsequently allowed the formulation of specific biochemical hypotheses. In sharp contrast, modern research on AD developed in the opposite order: the identification of the protein subunits of the classical brain lesions guided geneticists to disease-inducing genes, for example, APP, apolipoprotein E and tau. Thus, a biochemical hypothesis of disease - that AD is a progressive cerebral amyloidosis caused by the aggregation of the amyloid b-protein (Ab) - preceded and enabled the discovery of etiologies. - E-bokPDF, Engelska, 2012
1 470 kr
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Promising effects in mice of immunization by ß-amyloid stimulated substantial research efforts and high hopes. In retrospect, this study appears simultaneously logical, consistent as it is with the amyloid theory central today in the field of Alzheimer''s disease studies, and paradoxical, because it involved using the toxic substance itself for a treatment benefit. The research thus begun opens up multiple perspectives for experimentation and for treatment. Clinical trials began, but had to be stopped in January 2002 because of serious side effects. The editors'' objective for this book is not to arouse false hopes for a therapeutic project that must still be proven, but to discuss the available information and the questions it raises.
- Häftad, Engelska, 2011
1 137 kr
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Promising effects in mice of immunization by ß-amyloid stimulated substantial research efforts and high hopes. In retrospect, this study appears simultaneously logical, consistent as it is with the amyloid theory central today in the field of Alzheimer's disease studies, and paradoxical, because it involved using the toxic substance itself for a treatment benefit. The research thus begun opens up multiple perspectives for experimentation and for treatment. Clinical trials began, but had to be stopped in January 2002 because of serious side effects. The editors' objective for this book is not to arouse false hopes for a therapeutic project that must still be proven, but to discuss the available information and the questions it raises. - E-bokPDF, Engelska, 2012
1 427 kr
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Like the unflinching gaze of Captain Ahab walking the deck of the Pequod, Alzheimer researchers have had their sights fixed firmly on the disease for many years. Now, as this volume amply demonstrates, accomplished researchers from other fields, who have thought deeply about cell biological problems are applying their insights to Alzheimer''s disease. The contri butions here represent the text versions of the proceedings from the tenth "Colloque medecine et recherche" of the Fondation IPSEN devoted to research on Alzheimer''s disease. The symposium, entitled "Alzheimer''s Disease: Lessons from Cell Biology" was held in Paris on April 25, 1994. As is apparent from the varied backgrounds of the contributors, the scientific pursuit of Alzheimer''s disease has begun to meld with more basic disciplines, particularly cell biology. While on the one hand, new areas of specialization are continuously emerging, the boundaries of older disciplines are increas ingly blurred. Perhaps for most of the years since the first descriptions of the disease in 1907, the science of Alzheimer''s disease was descriptive, and lay in the province of pathologists. This time period, during which a great deal was learned about the topography of senile plaques and neurofibrillary tangles, culminated with an ultrastructural description of these hallmark structures. The modern era of Alzheimer''s disease research opened with the iden tification of the component proteins in plaques and tangles. - Häftad, Engelska, 2011
1 104 kr
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Like the unflinching gaze of Captain Ahab walking the deck of the Pequod, Alzheimer researchers have had their sights fixed firmly on the disease for many years. Now, as this volume amply demonstrates, accomplished researchers from other fields, who have thought deeply about cell biological problems are applying their insights to Alzheimer's disease. The contri butions here represent the text versions of the proceedings from the tenth "Colloque medecine et recherche" of the Fondation IPSEN devoted to research on Alzheimer's disease. The symposium, entitled "Alzheimer's Disease: Lessons from Cell Biology" was held in Paris on April 25, 1994. As is apparent from the varied backgrounds of the contributors, the scientific pursuit of Alzheimer's disease has begun to meld with more basic disciplines, particularly cell biology. While on the one hand, new areas of specialization are continuously emerging, the boundaries of older disciplines are increas ingly blurred. Perhaps for most of the years since the first descriptions of the disease in 1907, the science of Alzheimer's disease was descriptive, and lay in the province of pathologists. This time period, during which a great deal was learned about the topography of senile plaques and neurofibrillary tangles, culminated with an ultrastructural description of these hallmark structures. The modern era of Alzheimer's disease research opened with the iden tification of the component proteins in plaques and tangles.
