Dhruba Kumar Bhattacharyya - Böcker

Development of high-throughput technologies in molecular biology during the last two decades has contributed to the production of tremendous amounts of data. Microarray and RNA sequencing are two such widely used high-throughput technologies for simultaneously monitoring the expression patterns of thousands of genes. Data produced from such experiments are voluminous (both in dimensionality and numbers of instances) and evolving in nature. Analysis of huge amounts of data toward the identification of interesting patterns that are relevant for a given biological question requires high-performance computational infrastructure as well as efficient machine learning algorithms. Cross-communication of ideas between biologists and computer scientists remains a big challenge.Gene Expression Data Analysis: A Statistical and Machine Learning Perspective has been written with a multidisciplinary audience in mind. The book discusses gene expression data analysis from molecular biology, machine learning, and statistical perspectives. Readers will be able to acquire both theoretical and practical knowledge of methods for identifying novel patterns of high biological significance. To measure the effectiveness of such algorithms, we discuss statistical and biological performance metrics that can be used in real life or in a simulated environment. This book discusses a large number of benchmark algorithms, tools, systems, and repositories that are commonly used in analyzing gene expression data and validating results. This book will benefit students, researchers, and practitioners in biology, medicine, and computer science by enabling them to acquire in-depth knowledge in statistical and machine-learning-based methods for analyzing gene expression data.Key Features: An introduction to the Central Dogma of molecular biology and information flow in biological systems A systematic overview of the methods for generating gene expression data Background knowledge on statistical modeling and machine learning techniques Detailed methodology of analyzing gene expression data with an example case study Clustering methods for finding co-expression patterns from microarray, bulkRNA, and scRNA data A large number of practical tools, systems, and repositories that are useful for computational biologists to create, analyze, and validate biologically relevant gene expression patterns Suitable for multidisciplinary researchers and practitioners in computer science and biological sciences

Development of high-throughput technologies in molecular biology during the last two decades has contributed to the production of tremendous amounts of data. Microarray and RNA sequencing are two such widely used high-throughput technologies for simultaneously monitoring the expression patterns of thousands of genes. Data produced from such experiments are voluminous (both in dimensionality and numbers of instances) and evolving in nature. Analysis of huge amounts of data toward the identification of interesting patterns that are relevant for a given biological question requires high-performance computational infrastructure as well as efficient machine learning algorithms. Cross-communication of ideas between biologists and computer scientists remains a big challenge.Gene Expression Data Analysis: A Statistical and Machine Learning Perspective has been written with a multidisciplinary audience in mind. The book discusses gene expression data analysis from molecular biology, machine learning, and statistical perspectives. Readers will be able to acquire both theoretical and practical knowledge of methods for identifying novel patterns of high biological significance. To measure the effectiveness of such algorithms, we discuss statistical and biological performance metrics that can be used in real life or in a simulated environment. This book discusses a large number of benchmark algorithms, tools, systems, and repositories that are commonly used in analyzing gene expression data and validating results. This book will benefit students, researchers, and practitioners in biology, medicine, and computer science by enabling them to acquire in-depth knowledge in statistical and machine-learning-based methods for analyzing gene expression data.Key Features: An introduction to the Central Dogma of molecular biology and information flow in biological systems A systematic overview of the methods for generating gene expression data Background knowledge on statistical modeling and machine learning techniques Detailed methodology of analyzing gene expression data with an example case study Clustering methods for finding co-expression patterns from microarray, bulkRNA, and scRNA data A large number of practical tools, systems, and repositories that are useful for computational biologists to create, analyze, and validate biologically relevant gene expression patterns Suitable for multidisciplinary researchers and practitioners in computer science and biological sciences

With the rapid rise in the ubiquity and sophistication of Internet technology and the accompanying growth in the number of network attacks, network intrusion detection has become increasingly important. Anomaly-based network intrusion detection refers to finding exceptional or nonconforming patterns in network traffic data compared to normal behavior. Finding these anomalies has extensive applications in areas such as cyber security, credit card and insurance fraud detection, and military surveillance for enemy activities. Network Anomaly Detection: A Machine Learning Perspective presents machine learning techniques in depth to help you more effectively detect and counter network intrusion.In this book, you’ll learn about:Network anomalies and vulnerabilities at various layersThe pros and cons of various machine learning techniques and algorithmsA taxonomy of attacks based on their characteristics and behaviorFeature selection algorithmsHow to assess the accuracy, performance, completeness, timeliness, stability, interoperability, reliability, and other dynamic aspects of a network anomaly detection systemPractical tools for launching attacks, capturing packet or flow traffic, extracting features, detecting attacks, and evaluating detection performanceImportant unresolved issues and research challenges that need to be overcome to provide better protection for networksExamining numerous attacks in detail, the authors look at the tools that intruders use and show how to use this knowledge to protect networks. The book also provides material for hands-on development, so that you can code on a testbed to implement detection methods toward the development of your own intrusion detection system. It offers a thorough introduction to the state of the art in network anomaly detection using machine learning approaches and systems.

DDoS Attacks: Evolution, Detection, Prevention, Reaction, and Tolerance discusses the evolution of distributed denial-of-service (DDoS) attacks, how to detect a DDoS attack when one is mounted, how to prevent such attacks from taking place, and how to react when a DDoS attack is in progress, with the goal of tolerating the attack. It introduces types and characteristics of DDoS attacks, reasons why such attacks are often successful, what aspects of the network infrastructure are usual targets, and methods used to launch attacks.The book elaborates upon the emerging botnet technology, current trends in the evolution and use of botnet technology, its role in facilitating the launching of DDoS attacks, and challenges in countering the role of botnets in the proliferation of DDoS attacks. It introduces statistical and machine learning methods applied in the detection and prevention of DDoS attacks in order to provide a clear understanding of the state of the art. It presents DDoS reaction and tolerance mechanisms with a view to studying their effectiveness in protecting network resources without compromising the quality of services.To practically understand how attackers plan and mount DDoS attacks, the authors discuss the development of a testbed that can be used to perform experiments such as attack launching, monitoring of network traffic, and detection of attacks, as well as for testing strategies for prevention, reaction, and mitigation. Finally, the authors address current issues and challenges that need to be overcome to provide even better defense against DDoS attacks.

The two-volume set of LNCS 11941 and 11942 constitutes the refereed proceedings of the 8th International Conference on Pattern Recognition and Machine Intelligence, PReMI 2019, held in Tezpur, India, in December 2019. The 131 revised full papers presented were carefully reviewed and selected from 341 submissions.